AutismKB 2.0

Annotation Detail for HTR4


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Basic Information Top
Gene Symbol:HTR4 ( 5-HT4,5-HT4R )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 4
Band: 5q32
Quick LinksEntrez ID:3360; OMIM: 602164; Uniprot ID:5HT4R_HUMAN; ENSEMBL ID: ENSG00000164270; HGNC ID: 5299
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal9 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine3 / 23447212
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216939_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.45
Adipocyte4.7
AdrenalCortex5.45
Adrenalgland4.25
Amygdala4.85
Appendix4.8
AtrioventricularNode4.3
BDCA4+_DentriticCells5.1
Bonemarrow4.7
BronchialEpithelialCells4.6
CD105+_Endothelial4.7
CD14+_Monocytes5.05
CD19+_BCells(neg._sel.)4.95
CD33+_Myeloid5.9
CD34+5.85
CD4+_Tcells5
CD56+_NKCells5.25
CD71+_EarlyErythroid4.45
CD8+_Tcells4.45
CardiacMyocytes6.3
Caudatenucleus4.3
Cerebellum3.85
CerebellumPeduncles5.55
CiliaryGanglion3.95
CingulateCortex4.95
Colorectaladenocarcinoma4.7
DorsalRootGanglion3.75
FetalThyroid4.6
Fetalbrain4.75
Fetalliver4.25
Fetallung3.6
GlobusPallidus3.75
Heart6.25
Hypothalamus5.05
Kidney4.85
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.15
Leukemialymphoblastic(MOLT-4)3.8
Liver7
Lung5.2
Lymphnode4.05
Lymphoma_burkitts(Daudi)6.15
Lymphoma_burkitts(Raji)6.7
MedullaOblongata4.35
OccipitalLobe4.25
OlfactoryBulb3.8
Ovary3.2
Pancreas3.85
PancreaticIslet5.05
ParietalLobe5.25
Pituitary5.6
Placenta4.7
Pons5.35
PrefrontalCortex5.85
Prostate5.45
Salivarygland3.9
SkeletalMuscle6.3
Skin5.6
SmoothMuscle5.3
Spinalcord5.05
SubthalamicNucleus6.85
SuperiorCervicalGanglion23.4
TemporalLobe4.45
Testis4.05
TestisGermCell3.95
TestisIntersitial4.05
TestisLeydigCell4.95
TestisSeminiferousTubule4.05
Thalamus4.9
Thymus3.55
Thyroid5.65
Tongue8.1
Tonsil4.65
Trachea3.95
TrigeminalGanglion5.1
Uterus3.8
UterusCorpus4.85
WholeBlood5.1
Wholebrain3.95
colon4.7
pineal_day5.9
pineal_night5.8
retina6.625
small_intestine4.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1483_PI417557136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.98 ± 0.87
Basal Forebrain5.17 ± 0.64
Basal Part of Pons4.3 ± 0.83
Cerebellar Cortex3.84 ± 0.48
Cerebellar Nuclei4.35 ± 0.58
Claustrum4.09 ± 0.8
Epithalamus3.9 ± 0.75
Frontal Lobe4.52 ± 0.75
Globus Pallidus3.36 ± 0.92
Hypothalamus4.01 ± 0.76
Insula4.6 ± 0.6
Limbic Lobe5.47 ± 0.89
Mesencephalon4.57 ± 0.74
Myelencephalon4.65 ± 0.83
Occipital Lobe4.56 ± 0.85
Parietal Lobe4.64 ± 0.87
Pontine Tegmentum4.59 ± 0.91
Striatum6.96 ± 0.8
Subthalamus4.03 ± 0.66
Temporal Lobe4.92 ± 0.55
Thalamus3.81 ± 0.78
White Matter2.18 ± 2.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Htr4CBCerebellum4.44
7.46
Htr4CTXCerebral cortex1
0.98
Htr4HIPHippocampal region13.65
19.44
Htr4HPFHippocampal formation10.97
13.79
Htr4HYHypothalamus0.93
1
Htr4LSXLateral septal complex0.41
0.38
Htr4MBMidbrain1.44
1.6
Htr4MYMedulla1.2
1.46
Htr4OLFOlfactory bulb3.52
3.07
Htr4PPons1.4
1.5
Htr4PALPallidum0.82
0.87
Htr4RHPRetrohippocampal region5.78
4.41
Htr4sAMYStriatum-like amygdalar nuclei0.73
0.57
Htr4STRStriatum2.05
1.91
Htr4STRdStriatum dorsal region0.67
0.6
Htr4STRvStriatum ventral region7.44
6.57
Htr4THThalamus1.62
2.1
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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