AutismKB 2.0

Annotation Detail for TNC


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Basic Information Top
Gene Symbol:TNC ( 150-225,GMEM,GP,HXB,JI,MGC167029,TN,TN-C )
Gene Full Name: tenascin C
Band: 9q33.1
Quick LinksEntrez ID:3371; OMIM: 187380; Uniprot ID:TENA_HUMAN; ENSEMBL ID: ENSG00000041982; HGNC ID: 5318
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body38 / 70761537
blastocyst7 / 62319112
fetus41 / 56401272
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult300 / 1939121154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma35 / 174752002
breast (mammary gland) tumor11 / 94178116
cervical tumor0 / 343660 
chondrosarcoma26 / 82823313
colorectal tumor12 / 114246105
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor12 / 26384545
glioma30 / 106883280
head and neck tumor60 / 136302440
kidney tumor13 / 68959188
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor25 / 103127242
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal254 / 336030775
ovarian tumor5 / 7668265
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor19 / 124949152
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder35 / 297571176
blood0 / 1234780 
bone44 / 71655614
bone marrow1 / 4880120
brain61 / 110098955
cervix0 / 481710 
connective tissue21 / 149255140
ear3 / 16212185
embryonic tissue54 / 215722250
esophagus0 / 202090 
eye7 / 21105433
heart3 / 8962633
intestine34 / 234472145
kidney19 / 21177789
larynx31 / 241451283
liver5 / 20774324
lung68 / 336974201
lymph0 / 442700 
lymph node2 / 9161021
mammary gland17 / 153271110
mouth20 / 67052298
muscle5 / 10771546
nerve0 / 157680 
ovary5 / 10205148
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate5 / 18934526
salivary gland0 / 201550 
skin25 / 210574118
spleen0 / 539520 
stomach1 / 9661910
testis12 / 33044236
thymus1 / 8113112
thyroid8 / 47473168
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus26 / 232878111
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201645_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.85
Adipocyte246.2
AdrenalCortex7.65
Adrenalgland5.85
Amygdala8.35
Appendix21.2
AtrioventricularNode9.85
BDCA4+_DentriticCells6.15
Bonemarrow7.6
BronchialEpithelialCells223.55
CD105+_Endothelial36.7
CD14+_Monocytes7.1
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid8.3
CD34+7.45
CD4+_Tcells6.85
CD56+_NKCells7.05
CD71+_EarlyErythroid6.35
CD8+_Tcells5.45
CardiacMyocytes11
Caudatenucleus6.1
Cerebellum5.3
CerebellumPeduncles7.7
CiliaryGanglion4.95
CingulateCortex7.15
Colorectaladenocarcinoma6.55
DorsalRootGanglion15.3
FetalThyroid6.5
Fetalbrain101.65
Fetalliver5.75
Fetallung266.55
GlobusPallidus5.15
Heart9.2
Hypothalamus22.1
Kidney18.5
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)5.05
Liver9.45
Lung46.2
Lymphnode87.05
Lymphoma_burkitts(Daudi)8.4
Lymphoma_burkitts(Raji)9.6
MedullaOblongata5.75
OccipitalLobe5.6
OlfactoryBulb5.15
Ovary8
Pancreas6.05
PancreaticIslet7.15
ParietalLobe7.55
Pituitary7.8
Placenta8.1
Pons6.6
PrefrontalCortex7.25
Prostate85.1
Salivarygland5.5
SkeletalMuscle8.2
Skin6.4
SmoothMuscle116.4
Spinalcord12.95
SubthalamicNucleus6.35
SuperiorCervicalGanglion8.3
TemporalLobe6.15
Testis6.15
TestisGermCell8.35
TestisIntersitial6.85
TestisLeydigCell6.9
TestisSeminiferousTubule5.3
Thalamus14.95
Thymus24.7
Thyroid8.35
Tongue7.6
Tonsil10
Trachea53.35
TrigeminalGanglion7.15
Uterus271.85
UterusCorpus21
WholeBlood6.75
Wholebrain5.75
colon308.8
pineal_day32.5
pineal_night9.22
retina21.425
small_intestine457.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P215745
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.19 ± 0.98
Basal Forebrain1.77 ± 0.21
Basal Part of Pons1.52 ± 0.42
Cerebellar Cortex1.62 ± 0.66
Cerebellar Nuclei2.08 ± 0.71
Claustrum2.65 ± 0.85
Epithalamus1.51 ± 0.69
Frontal Lobe1.62 ± 0.55
Globus Pallidus2.46 ± 0.38
Hypothalamus1.94 ± 0.64
Insula1.67 ± 0.52
Limbic Lobe1.78 ± 0.61
Mesencephalon1.95 ± 0.69
Myelencephalon1.81 ± 0.64
Occipital Lobe1.89 ± 0.6
Parietal Lobe1.79 ± 0.71
Pontine Tegmentum1.84 ± 0.66
Striatum1.95 ± 0.5
Subthalamus1.93 ± 0.64
Temporal Lobe1.69 ± 0.65
Thalamus1.78 ± 0.58
White Matter2.35 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TncCBCerebellum16.45
32.35
TncCTXCerebral cortex1.85
2.18
TncHIPHippocampal region3
3.09
TncHPFHippocampal formation2.27
2.17
TncHYHypothalamus0.78
0.7
TncLSXLateral septal complex0.73
0.7
TncMBMidbrain1.5
1.7
TncMYMedulla2.44
2.83
TncOLFOlfactory bulb1.61
1.78
TncPPons1.53
1.77
TncPALPallidum0.64
0.83
TncRHPRetrohippocampal region1.17
1
TncsAMYStriatum-like amygdalar nuclei2.47
2.74
TncSTRStriatum0.79
0.92
TncSTRdStriatum dorsal region0.6
0.76
TncSTRvStriatum ventral region0.39
0.4
TncTHThalamus10.56
10.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025616 18 462 479 GYDCSDMSCPNDCHQHGR Peptide Atlas
TENA_HUMAN_1768 15 1768 1782 LIPGVEYLVSIIAMK PRIDE
TENA_HUMAN_23 8 23 30 GVLKKVIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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