AutismKB 2.0

Annotation Detail for ICA1


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Basic Information Top
Gene Symbol:ICA1 ( ICA69,ICAp69 )
Gene Full Name: islet cell autoantigen 1, 69kDa
Band: 7p21.3
Quick LinksEntrez ID:3382; OMIM: 147625; Uniprot ID:ICA69_HUMAN; ENSEMBL ID: ENSG00000003147; HGNC ID: 5343
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus12 / 56401221
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal102 / 336030730
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites5 / 40015124
bladder1 / 2975733
blood5 / 12347840
bone1 / 7165513
bone marrow1 / 4880120
brain33 / 110098929
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye3 / 21105414
heart7 / 8962678
intestine23 / 23447298
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung13 / 33697438
lymph0 / 442700 
lymph node3 / 9161032
mammary gland5 / 15327132
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas16 / 21481274
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate8 / 18934542
salivary gland1 / 2015549
skin2 / 2105749
spleen1 / 5395218
stomach1 / 9661910
testis15 / 33044245
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204002_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.35
AdrenalCortex4.9
Adrenalgland3.7
Amygdala4.7
Appendix4.5
AtrioventricularNode4.95
BDCA4+_DentriticCells4.75
Bonemarrow4.65
BronchialEpithelialCells4.25
CD105+_Endothelial4.4
CD14+_Monocytes4.7
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid5.5
CD34+5.65
CD4+_Tcells4.65
CD56+_NKCells5.2
CD71+_EarlyErythroid5.45
CD8+_Tcells4.2
CardiacMyocytes5.6
Caudatenucleus4.25
Cerebellum5.55
CerebellumPeduncles5.1
CiliaryGanglion3.1
CingulateCortex4.55
Colorectaladenocarcinoma4.4
DorsalRootGanglion3.3
FetalThyroid4.4
Fetalbrain4.35
Fetalliver3.85
Fetallung3.65
GlobusPallidus3.35
Heart6.05
Hypothalamus4.8
Kidney3.9
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.5
Liver5.95
Lung4.85
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.6
Lymphoma_burkitts(Raji)6.25
MedullaOblongata4.75
OccipitalLobe3.95
OlfactoryBulb3.45
Ovary2.95
Pancreas3.55
PancreaticIslet4.7
ParietalLobe4.7
Pituitary5.15
Placenta4.6
Pons4.3
PrefrontalCortex5.7
Prostate5.1
Salivarygland3.55
SkeletalMuscle5.3
Skin3.8
SmoothMuscle5
Spinalcord4.65
SubthalamicNucleus3.95
SuperiorCervicalGanglion5.1
TemporalLobe4.05
Testis3.8
TestisGermCell3.6
TestisIntersitial3.6
TestisLeydigCell4.3
TestisSeminiferousTubule3.75
Thalamus4.85
Thymus3.4
Thyroid5.4
Tongue4.4
Tonsil4.25
Trachea3.65
TrigeminalGanglion6.55
Uterus3.5
UterusCorpus3.95
WholeBlood4.75
Wholebrain3.8
colon4.4
pineal_day5.52
pineal_night5.28
retina5.325
small_intestine4.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P215419
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.98 ± 0.32
Basal Forebrain8.48 ± 0.23
Basal Part of Pons9.54 ± 0.16
Cerebellar Cortex9.23 ± 0.13
Cerebellar Nuclei8.97 ± 0.42
Claustrum8.6 ± 0.29
Epithalamus7.79 ± 0.71
Frontal Lobe8.84 ± 0.37
Globus Pallidus7.63 ± 0.38
Hypothalamus8.54 ± 0.32
Insula8.9 ± 0.27
Limbic Lobe8.94 ± 0.36
Mesencephalon8.68 ± 0.4
Myelencephalon8.82 ± 0.51
Occipital Lobe9.48 ± 0.42
Parietal Lobe9.08 ± 0.33
Pontine Tegmentum8.8 ± 0.4
Striatum8.58 ± 0.36
Subthalamus8.76 ± 0.14
Temporal Lobe9 ± 0.3
Thalamus9.29 ± 0.39
White Matter6.9 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ica1CBCerebellum22.26
19.91
Ica1CTXCerebral cortex51.41
43.31
Ica1HIPHippocampal region51.85
45.42
Ica1HPFHippocampal formation52.8
45.14
Ica1HYHypothalamus35.51
23.43
Ica1LSXLateral septal complex34.28
22.48
Ica1MBMidbrain38.08
32.84
Ica1MYMedulla38.59
36.64
Ica1OLFOlfactory bulb46.21
40.31
Ica1PPons38.88
34.67
Ica1PALPallidum35.42
24.13
Ica1RHPRetrohippocampal region54.89
45.06
Ica1sAMYStriatum-like amygdalar nuclei39.32
30.33
Ica1STRStriatum35.88
32.12
Ica1STRdStriatum dorsal region35.17
30.34
Ica1STRvStriatum ventral region37.61
35.31
Ica1THThalamus38.27
30.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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