AutismKB 2.0

Annotation Detail for ID2


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Basic Information Top
Gene Symbol:ID2 ( GIG8,ID2A,ID2H,MGC26389,bHLHb26 )
Gene Full Name: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Band: 2p25.1
Quick LinksEntrez ID:3398; OMIM: 600386; Uniprot ID:ID2_HUMAN; ENSEMBL ID: ENSG00000115738; HGNC ID: 5361
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst2 / 6231932
fetus83 / 564012147
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult190 / 193912197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor12 / 119369100
germ cell tumor5 / 26384518
glioma11 / 106883102
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor19 / 96359197
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia4 / 9725041
normal356 / 3360307105
ovarian tumor9 / 76682117
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland7 / 33197210
ascites2 / 4001549
bladder2 / 2975767
blood10 / 12347880
bone11 / 71655153
bone marrow3 / 4880161
brain111 / 1100989100
cervix0 / 481710 
connective tissue6 / 14925540
ear4 / 16212246
embryonic tissue29 / 215722134
esophagus1 / 2020949
eye17 / 21105480
heart23 / 89626256
intestine26 / 234472110
kidney18 / 21177784
larynx2 / 2414582
liver48 / 207743231
lung45 / 336974133
lymph0 / 442700 
lymph node9 / 9161098
mammary gland10 / 15327165
mouth0 / 670520 
muscle0 / 1077150 
nerve3 / 15768190
ovary11 / 102051107
pancreas21 / 21481297
parathyroid53 / 205392580
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate4 / 18934521
salivary gland0 / 201550 
skin18 / 21057485
spleen0 / 539520 
stomach16 / 96619165
testis8 / 33044224
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus27 / 232878115
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201565_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1928.9
Adipocyte252.4
AdrenalCortex657.15
Adrenalgland368.3
Amygdala459.15
Appendix88.95
AtrioventricularNode21.6
BDCA4+_DentriticCells1652.55
Bonemarrow326.3
BronchialEpithelialCells16.9
CD105+_Endothelial151.25
CD14+_Monocytes1896.4
CD19+_BCells(neg._sel.)129.95
CD33+_Myeloid3077.1
CD34+160.2
CD4+_Tcells1662.55
CD56+_NKCells5472.7
CD71+_EarlyErythroid712.45
CD8+_Tcells2285.6
CardiacMyocytes179.75
Caudatenucleus73.45
Cerebellum102.95
CerebellumPeduncles157.75
CiliaryGanglion57.85
CingulateCortex376.35
Colorectaladenocarcinoma966.75
DorsalRootGanglion55.95
FetalThyroid541.85
Fetalbrain621.05
Fetalliver520.7
Fetallung346.2
GlobusPallidus223.25
Heart151.4
Hypothalamus196.95
Kidney254.4
Leukemia_chronicMyelogenousK-56228.15
Leukemia_promyelocytic-HL-6061.6
Leukemialymphoblastic(MOLT-4)10.1
Liver2176.55
Lung969.7
Lymphnode187.6
Lymphoma_burkitts(Daudi)22.6
Lymphoma_burkitts(Raji)134.7
MedullaOblongata194
OccipitalLobe479.2
OlfactoryBulb170.7
Ovary1067.95
Pancreas222.3
PancreaticIslet210.35
ParietalLobe279.85
Pituitary170.6
Placenta127.5
Pons196.65
PrefrontalCortex1289.7
Prostate1167.75
Salivarygland104.9
SkeletalMuscle31.05
Skin95.15
SmoothMuscle488.8
Spinalcord176.75
SubthalamicNucleus253.1
SuperiorCervicalGanglion119.15
TemporalLobe362.15
Testis49.2
TestisGermCell49.7
TestisIntersitial49
TestisLeydigCell51.05
TestisSeminiferousTubule39.25
Thalamus69.25
Thymus444.05
Thyroid1563.2
Tongue78.7
Tonsil81.25
Trachea459.55
TrigeminalGanglion98.2
Uterus467.55
UterusCorpus87.55
WholeBlood827.15
Wholebrain860.35
colon1550.4
pineal_day179.4
pineal_night129.44
retina867.425
small_intestine1020.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P143143
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.99 ± 0.33
Basal Forebrain10.92 ± 0.26
Basal Part of Pons10.61 ± 0.33
Cerebellar Cortex10.73 ± 0.22
Cerebellar Nuclei10.21 ± 0.36
Claustrum11.1 ± 0.43
Epithalamus11.73 ± 0.27
Frontal Lobe10.9 ± 0.36
Globus Pallidus10.78 ± 0.37
Hypothalamus11.18 ± 0.42
Insula10.95 ± 0.17
Limbic Lobe10.76 ± 0.52
Mesencephalon10.99 ± 0.49
Myelencephalon10.97 ± 0.39
Occipital Lobe11.3 ± 0.4
Parietal Lobe11.14 ± 0.41
Pontine Tegmentum11.03 ± 0.38
Striatum10.24 ± 0.67
Subthalamus10.31 ± 0.46
Temporal Lobe11.12 ± 0.22
Thalamus11.05 ± 0.34
White Matter9.65 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Id2CBCerebellum54.23
100
Id2CTXCerebral cortex99.31
100
Id2HIPHippocampal region27.25
42.48
Id2HPFHippocampal formation36.73
55.4
Id2HYHypothalamus11.68
10.24
Id2LSXLateral septal complex16.85
16.95
Id2MBMidbrain16.19
17.84
Id2MYMedulla15.85
19.29
Id2OLFOlfactory bulb91.6
100
Id2PPons12.25
13.38
Id2PALPallidum10.08
8.97
Id2RHPRetrohippocampal region50.71
70.75
Id2sAMYStriatum-like amygdalar nuclei14.43
13.52
Id2STRStriatum11.96
11.5
Id2STRdStriatum dorsal region10.98
11.03
Id2STRvStriatum ventral region12.14
9.92
Id2THThalamus16.5
16.49
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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