AutismKB 2.0

Annotation Detail for ID3


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Basic Information Top
Gene Symbol:ID3 ( HEIR-1,bHLHb25 )
Gene Full Name: inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Band: 1p36.12
Quick LinksEntrez ID:3399; OMIM: 600277; Uniprot ID:ID3_HUMAN; ENSEMBL ID: ENSG00000117318; HGNC ID: 5362
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body19 / 70761268
blastocyst8 / 62319128
fetus41 / 56401272
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult188 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor17 / 94178180
cervical tumor10 / 34366290
chondrosarcoma25 / 82823301
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor24 / 119369201
germ cell tumor9 / 26384534
glioma25 / 106883233
head and neck tumor12 / 13630288
kidney tumor10 / 68959145
leukemia7 / 9584273
liver tumor6 / 9635962
lung tumor10 / 10312796
lymphoma8 / 71755111
non-neoplasia7 / 9725071
normal292 / 336030786
ovarian tumor10 / 76682130
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor58 / 124949464
soft tissue/muscle tissue tumor47 / 125191375
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites5 / 40015124
bladder5 / 29757168
blood6 / 12347848
bone16 / 71655223
bone marrow2 / 4880140
brain85 / 110098977
cervix11 / 48171228
connective tissue16 / 149255107
ear18 / 162121110
embryonic tissue49 / 215722227
esophagus0 / 202090 
eye27 / 211054127
heart1 / 8962611
intestine30 / 234472127
kidney18 / 21177784
larynx2 / 2414582
liver9 / 20774343
lung30 / 33697489
lymph6 / 44270135
lymph node1 / 9161010
mammary gland19 / 153271123
mouth2 / 6705229
muscle16 / 107715148
nerve5 / 15768317
ovary19 / 102051186
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta41 / 280825145
prostate13 / 18934568
salivary gland6 / 20155297
skin69 / 210574327
spleen3 / 5395255
stomach25 / 96619258
testis3 / 3304429
thymus1 / 8113112
thyroid1 / 4747321
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord0 / 136800 
uterus62 / 232878266
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207826_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.1
Adipocyte27.5
AdrenalCortex12.75
Adrenalgland10.4
Amygdala12.25
Appendix14.6
AtrioventricularNode11.75
BDCA4+_DentriticCells11.95
Bonemarrow6.1
BronchialEpithelialCells13.35
CD105+_Endothelial11.5
CD14+_Monocytes8.55
CD19+_BCells(neg._sel.)28.85
CD33+_Myeloid9.4
CD34+10.45
CD4+_Tcells10.6
CD56+_NKCells4.85
CD71+_EarlyErythroid8.2
CD8+_Tcells9.35
CardiacMyocytes181.75
Caudatenucleus10.55
Cerebellum8.6
CerebellumPeduncles6.6
CiliaryGanglion14.95
CingulateCortex11.2
Colorectaladenocarcinoma11.05
DorsalRootGanglion12.75
FetalThyroid57.45
Fetalbrain11.3
Fetalliver10.1
Fetallung32.45
GlobusPallidus7.15
Heart134.2
Hypothalamus12.55
Kidney12.25
Leukemia_chronicMyelogenousK-5629.85
Leukemia_promyelocytic-HL-6030.7
Leukemialymphoblastic(MOLT-4)6.85
Liver21.3
Lung107.05
Lymphnode14.4
Lymphoma_burkitts(Daudi)198.3
Lymphoma_burkitts(Raji)48.95
MedullaOblongata7.1
OccipitalLobe9.4
OlfactoryBulb63.6
Ovary7.85
Pancreas14.1
PancreaticIslet12.45
ParietalLobe8.25
Pituitary25.15
Placenta48.6
Pons6.75
PrefrontalCortex14.25
Prostate129.95
Salivarygland9.6
SkeletalMuscle13.75
Skin9.25
SmoothMuscle96.55
Spinalcord20.45
SubthalamicNucleus10.7
SuperiorCervicalGanglion16.35
TemporalLobe7.7
Testis6.3
TestisGermCell6.15
TestisIntersitial6.3
TestisLeydigCell7.9
TestisSeminiferousTubule7.7
Thalamus11.9
Thymus33.05
Thyroid546.5
Tongue11.6
Tonsil11.55
Trachea12.4
TrigeminalGanglion15.75
Uterus25.35
UterusCorpus10.7
WholeBlood4.75
Wholebrain12.2
colon70.9
pineal_day11.94
pineal_night12.74
retina95.375
small_intestine20.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P137381
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.95 ± 0.49
Basal Forebrain6.27 ± 0.18
Basal Part of Pons6.19 ± 0.56
Cerebellar Cortex6.05 ± 0.32
Cerebellar Nuclei6.54 ± 0.35
Claustrum5.94 ± 0.79
Epithalamus7.53 ± 0.5
Frontal Lobe6.5 ± 0.55
Globus Pallidus6.93 ± 0.31
Hypothalamus6.61 ± 0.66
Insula6.49 ± 0.44
Limbic Lobe6.23 ± 0.61
Mesencephalon6.42 ± 0.53
Myelencephalon6.52 ± 0.53
Occipital Lobe6.67 ± 0.43
Parietal Lobe6.41 ± 0.54
Pontine Tegmentum6.53 ± 0.48
Striatum6.37 ± 0.77
Subthalamus6.17 ± 0.7
Temporal Lobe6.47 ± 0.5
Thalamus6.61 ± 0.59
White Matter5.45 ± 0.72
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Id3CBCerebellum29.89
41.92
Id3CTXCerebral cortex18.11
17.12
Id3HIPHippocampal region36.78
51.91
Id3HPFHippocampal formation32.37
40.75
Id3HYHypothalamus8.38
8.73
Id3LSXLateral septal complex13.55
20.26
Id3MBMidbrain18.28
22.41
Id3MYMedulla20.82
28.11
Id3OLFOlfactory bulb28.24
28.66
Id3PPons17.61
20.94
Id3PALPallidum14.64
14.96
Id3RHPRetrohippocampal region26.37
27.37
Id3sAMYStriatum-like amygdalar nuclei9.94
12.43
Id3STRStriatum20.06
20.19
Id3STRdStriatum dorsal region22.83
22.36
Id3STRvStriatum ventral region17.86
16.16
Id3THThalamus24.66
30.69
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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