AutismKB 2.0

Annotation Detail for IDH3B


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Basic Information Top
Gene Symbol:IDH3B ( FLJ11043,H-IDHB,MGC903,RP46 )
Gene Full Name: isocitrate dehydrogenase 3 (NAD+) beta
Band: 20p13
Quick LinksEntrez ID:3420; OMIM: 604526; Uniprot ID:IDH3B_HUMAN; ENSEMBL ID: ENSG00000101365; HGNC ID: 5385
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst10 / 62319160
fetus45 / 56401279
neonate0 / 310970 
infant3 / 23620127
juvenile5 / 5555689
adult269 / 1939121138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma4 / 17475228
breast (mammary gland) tumor10 / 94178106
cervical tumor10 / 34366290
chondrosarcoma5 / 8282360
colorectal tumor20 / 114246175
esophageal tumor0 / 172900 
gastrointestinal tumor29 / 119369242
germ cell tumor37 / 263845140
glioma6 / 10688356
head and neck tumor22 / 136302161
kidney tumor11 / 68959159
leukemia12 / 95842125
liver tumor34 / 96359352
lung tumor27 / 103127261
lymphoma11 / 71755153
non-neoplasia11 / 97250113
normal408 / 3360307121
ovarian tumor17 / 76682221
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer12 / 102680116
retinoblastoma18 / 46356388
skin tumor39 / 124949312
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites18 / 40015449
bladder4 / 29757134
blood34 / 123478275
bone3 / 7165541
bone marrow5 / 48801102
brain163 / 1100989148
cervix18 / 48171373
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue28 / 215722129
esophagus0 / 202090 
eye33 / 211054156
heart16 / 89626178
intestine37 / 234472157
kidney27 / 211777127
larynx11 / 24145455
liver45 / 207743216
lung49 / 336974145
lymph11 / 44270248
lymph node6 / 9161065
mammary gland15 / 15327197
mouth4 / 6705259
muscle19 / 107715176
nerve3 / 15768190
ovary24 / 102051235
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta55 / 280825195
prostate21 / 189345110
salivary gland1 / 2015549
skin42 / 210574199
spleen14 / 53952259
stomach14 / 96619144
testis22 / 33044266
thymus20 / 81131246
thyroid13 / 47473273
tonsil7 / 16999411
trachea1 / 5241319
umbilical cord0 / 136800 
uterus30 / 232878128
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210014_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts542.55
Adipocyte141.05
AdrenalCortex69.4
Adrenalgland69
Amygdala176.5
Appendix61.1
AtrioventricularNode44.25
BDCA4+_DentriticCells364.45
Bonemarrow72.05
BronchialEpithelialCells331.9
CD105+_Endothelial347.1
CD14+_Monocytes367.25
CD19+_BCells(neg._sel.)322.3
CD33+_Myeloid366.75
CD34+492.4
CD4+_Tcells344.55
CD56+_NKCells361.15
CD71+_EarlyErythroid152.7
CD8+_Tcells334.1
CardiacMyocytes123.25
Caudatenucleus122.7
Cerebellum165.3
CerebellumPeduncles327.25
CiliaryGanglion10.6
CingulateCortex57.2
Colorectaladenocarcinoma320.3
DorsalRootGanglion34
FetalThyroid203.6
Fetalbrain158
Fetalliver81.4
Fetallung123.8
GlobusPallidus66.25
Heart696.35
Hypothalamus296.7
Kidney97.55
Leukemia_chronicMyelogenousK-562247.9
Leukemia_promyelocytic-HL-60428.25
Leukemialymphoblastic(MOLT-4)451.55
Liver114.85
Lung285.65
Lymphnode142.2
Lymphoma_burkitts(Daudi)275.1
Lymphoma_burkitts(Raji)517
MedullaOblongata130.7
OccipitalLobe157.8
OlfactoryBulb85.3
Ovary58.8
Pancreas49.9
PancreaticIslet134.5
ParietalLobe128.05
Pituitary74.55
Placenta153.95
Pons65.95
PrefrontalCortex149.7
Prostate222.7
Salivarygland45.95
SkeletalMuscle133.35
Skin44.95
SmoothMuscle95.9
Spinalcord86.4
SubthalamicNucleus111.55
SuperiorCervicalGanglion38.05
TemporalLobe120.8
Testis127.05
TestisGermCell143.6
TestisIntersitial85.9
TestisLeydigCell80.85
TestisSeminiferousTubule69.55
Thalamus176
Thymus219.85
Thyroid352.95
Tongue167.5
Tonsil120.35
Trachea43.8
TrigeminalGanglion29.4
Uterus166.95
UterusCorpus74
WholeBlood126.25
Wholebrain416
colon242.8
pineal_day216.56
pineal_night203.12
retina243.8
small_intestine229.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11583_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.5 ± 0.57
Basal Forebrain5.8 ± 0.28
Basal Part of Pons6.53 ± 0.44
Cerebellar Cortex6.27 ± 0.37
Cerebellar Nuclei6.57 ± 0.69
Claustrum5.5 ± 0.68
Epithalamus5.7 ± 0.43
Frontal Lobe6.22 ± 0.43
Globus Pallidus5.48 ± 0.4
Hypothalamus6.15 ± 0.23
Insula6 ± 0.36
Limbic Lobe5.85 ± 0.61
Mesencephalon5.94 ± 0.58
Myelencephalon5.9 ± 0.66
Occipital Lobe5.54 ± 0.58
Parietal Lobe5.96 ± 0.54
Pontine Tegmentum6.01 ± 0.45
Striatum5.3 ± 0.45
Subthalamus6.28 ± 0.93
Temporal Lobe6.13 ± 0.44
Thalamus6.12 ± 0.51
White Matter5.25 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Idh3bCBCerebellum45.24
100
Idh3bCTXCerebral cortex100
100
Idh3bHIPHippocampal region100
100
Idh3bHPFHippocampal formation100
100
Idh3bHYHypothalamus99.34
100
Idh3bLSXLateral septal complex100
100
Idh3bMBMidbrain100
100
Idh3bMYMedulla100
100
Idh3bOLFOlfactory bulb100
100
Idh3bPPons93.15
100
Idh3bPALPallidum100
100
Idh3bRHPRetrohippocampal region100
100
Idh3bsAMYStriatum-like amygdalar nuclei91.79
89.05
Idh3bSTRStriatum100
96.18
Idh3bSTRdStriatum dorsal region100
100
Idh3bSTRvStriatum ventral region99.8
86.81
Idh3bTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IDH3B_HUMAN_134 12 134 145 KLDLFANVVHVK PRIDE
IDH3B_HUMAN_164 16 164 179 EQTEGEYSSLEHESAR PRIDE
IDH3B_HUMAN_317 17 317 333 NIANPTAMLLSASNMLR PRIDE
IDH3B_HUMAN_334 17 334 350 HLNLEYHSSMIADAVKK PRIDE
IDH3B_HUMAN_37 31 37 67 SQAEDVRVEGSFPVTMLPGDGVGPELMHAVK PRIDE
IDH3B_HUMAN_45 24 45 68 VEGSFPVTMLPGDGVGPELMHAVK PRIDE
PAp00000132 24 73 96 AAAVPVEFQEHHLSEVQNMASEEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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