AutismKB 2.0

Annotation Detail for APOE


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Basic Information Top
Gene Symbol:APOE ( AD2,LDLCQ5,LPG,MGC1571 )
Gene Full Name: apolipoprotein E
Band: 19q13.32
Quick LinksEntrez ID:348; OMIM: 107741; Uniprot ID:APOE_HUMAN; ENSEMBL ID: ENSG00000130203; HGNC ID: 613
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body32 / 70761452
blastocyst24 / 62319385
fetus67 / 564012118
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult317 / 1939121163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor14 / 94178148
cervical tumor0 / 343660 
chondrosarcoma31 / 82823374
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor50 / 263845189
glioma321 / 1068833003
head and neck tumor5 / 13630236
kidney tumor10 / 68959145
leukemia1 / 9584210
liver tumor46 / 96359477
lung tumor12 / 103127116
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal509 / 3360307151
ovarian tumor14 / 76682182
pancreatic tumor19 / 104616181
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma3 / 4635664
skin tumor174 / 1249491392
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland21 / 33197632
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone11 / 71655153
bone marrow0 / 488010 
brain655 / 1100989594
cervix3 / 4817162
connective tissue23 / 149255154
ear0 / 162120 
embryonic tissue63 / 215722292
esophagus1 / 2020949
eye27 / 211054127
heart10 / 89626111
intestine24 / 234472102
kidney107 / 211777505
larynx0 / 241450 
liver79 / 207743380
lung116 / 336974344
lymph0 / 442700 
lymph node5 / 9161054
mammary gland22 / 153271143
mouth3 / 6705244
muscle2 / 10771518
nerve1 / 1576863
ovary36 / 102051352
pancreas24 / 214812111
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta17 / 28082560
prostate11 / 18934558
salivary gland0 / 201550 
skin176 / 210574835
spleen17 / 53952315
stomach4 / 9661941
testis15 / 33044245
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212884_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts154.7
Adipocyte1787.5
AdrenalCortex1619.1
Adrenalgland1051.2
Amygdala1353.35
Appendix192.7
AtrioventricularNode175.1
BDCA4+_DentriticCells83.65
Bonemarrow151.45
BronchialEpithelialCells84.9
CD105+_Endothelial470.9
CD14+_Monocytes113
CD19+_BCells(neg._sel.)71.05
CD33+_Myeloid208.4
CD34+162.5
CD4+_Tcells173.8
CD56+_NKCells117.35
CD71+_EarlyErythroid205.55
CD8+_Tcells181.1
CardiacMyocytes310.15
Caudatenucleus780.85
Cerebellum287.65
CerebellumPeduncles685.3
CiliaryGanglion295.9
CingulateCortex414.8
Colorectaladenocarcinoma247.7
DorsalRootGanglion218.45
FetalThyroid259.65
Fetalbrain259.95
Fetalliver581.9
Fetallung600.75
GlobusPallidus268.25
Heart908.05
Hypothalamus1430.85
Kidney542.15
Leukemia_chronicMyelogenousK-562231.5
Leukemia_promyelocytic-HL-6060.65
Leukemialymphoblastic(MOLT-4)45.2
Liver3766.75
Lung840.75
Lymphnode568.2
Lymphoma_burkitts(Daudi)79.85
Lymphoma_burkitts(Raji)231.85
MedullaOblongata440.9
OccipitalLobe529.4
OlfactoryBulb246.8
Ovary173.05
Pancreas97.55
PancreaticIslet149.3
ParietalLobe344.45
Pituitary193.25
Placenta171.35
Pons495.15
PrefrontalCortex711
Prostate229.2
Salivarygland154
SkeletalMuscle85.95
Skin200.7
SmoothMuscle60.8
Spinalcord842.95
SubthalamicNucleus373.3
SuperiorCervicalGanglion168.55
TemporalLobe426.05
Testis233.3
TestisGermCell121.25
TestisIntersitial203.9
TestisLeydigCell217.45
TestisSeminiferousTubule298.9
Thalamus789.65
Thymus187.55
Thyroid292.25
Tongue84.85
Tonsil239.85
Trachea69.75
TrigeminalGanglion336.65
Uterus157.65
UterusCorpus224.05
WholeBlood54.1
Wholebrain771.65
colon204.5
pineal_day709.48
pineal_night500.04
retina599.225
small_intestine174.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P164650
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.21 ± 0.31
Basal Forebrain13.48 ± 0.2
Basal Part of Pons11.97 ± 0.32
Cerebellar Cortex12.3 ± 0.22
Cerebellar Nuclei12.29 ± 0.61
Claustrum12.18 ± 0.61
Epithalamus12.95 ± 0.39
Frontal Lobe12.57 ± 0.5
Globus Pallidus14.75 ± 0.63
Hypothalamus13.44 ± 0.19
Insula12.67 ± 0.52
Limbic Lobe12.47 ± 0.7
Mesencephalon13.21 ± 0.69
Myelencephalon12.93 ± 0.66
Occipital Lobe12.97 ± 0.43
Parietal Lobe12.73 ± 0.58
Pontine Tegmentum13.04 ± 0.46
Striatum14.14 ± 0.57
Subthalamus12.53 ± 0.48
Temporal Lobe12.8 ± 0.46
Thalamus13.39 ± 0.46
White Matter11.86 ± 0.76
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ApoeCBCerebellum100
100
ApoeCTXCerebral cortex100
100
ApoeHIPHippocampal region100
100
ApoeHPFHippocampal formation100
100
ApoeHYHypothalamus100
100
ApoeLSXLateral septal complex100
100
ApoeMBMidbrain100
100
ApoeMYMedulla100
100
ApoeOLFOlfactory bulb100
100
ApoePPons100
100
ApoePALPallidum100
100
ApoeRHPRetrohippocampal region100
100
ApoesAMYStriatum-like amygdalar nuclei100
100
ApoeSTRStriatum100
100
ApoeSTRdStriatum dorsal region100
100
ApoeSTRvStriatum ventral region100
100
ApoeTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004883 11 122 132 LGADMEDVCGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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