AutismKB 2.0

Annotation Detail for IGF2R


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Basic Information Top
Gene Symbol:IGF2R ( CD222,CIMPR,M6P-R,MPR1,MPRI )
Gene Full Name: insulin-like growth factor 2 receptor
Band: 6q25.3
Quick LinksEntrez ID:3482; OMIM: 147280; Uniprot ID:MPRI_HUMAN; ENSEMBL ID: ENSG00000197081; HGNC ID: 5467
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst9 / 62319144
fetus38 / 56401267
neonate1 / 3109732
infant0 / 236200 
juvenile10 / 55556179
adult230 / 1939121118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma4 / 17475228
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma20 / 82823241
colorectal tumor20 / 114246175
esophageal tumor1 / 1729057
gastrointestinal tumor12 / 119369100
germ cell tumor16 / 26384560
glioma7 / 10688365
head and neck tumor19 / 136302139
kidney tumor1 / 6895914
leukemia20 / 95842208
liver tumor14 / 96359145
lung tumor8 / 10312777
lymphoma2 / 7175527
non-neoplasia8 / 9725082
normal260 / 336030777
ovarian tumor3 / 7668239
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer16 / 102680155
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites5 / 40015124
bladder3 / 29757100
blood17 / 123478137
bone11 / 71655153
bone marrow0 / 488010 
brain41 / 110098937
cervix0 / 481710 
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus1 / 2020949
eye27 / 211054127
heart6 / 8962666
intestine34 / 234472145
kidney34 / 211777160
larynx2 / 2414582
liver17 / 20774381
lung42 / 336974124
lymph0 / 442700 
lymph node18 / 91610196
mammary gland18 / 153271117
mouth6 / 6705289
muscle20 / 107715185
nerve2 / 15768126
ovary4 / 10205139
pancreas25 / 214812116
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta13 / 28082546
prostate28 / 189345147
salivary gland2 / 2015599
skin12 / 21057456
spleen9 / 53952166
stomach2 / 9661920
testis15 / 33044245
thymus4 / 8113149
thyroid9 / 47473189
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord0 / 136800 
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201393_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts71.55
Adipocyte70.5
AdrenalCortex14
Adrenalgland46.95
Amygdala19.75
Appendix8.7
AtrioventricularNode9.1
BDCA4+_DentriticCells214.65
Bonemarrow43.8
BronchialEpithelialCells72.7
CD105+_Endothelial14.75
CD14+_Monocytes110
CD19+_BCells(neg._sel.)14.4
CD33+_Myeloid258.65
CD34+10.65
CD4+_Tcells32.95
CD56+_NKCells475.7
CD71+_EarlyErythroid20.8
CD8+_Tcells88.45
CardiacMyocytes33.6
Caudatenucleus11.2
Cerebellum10.9
CerebellumPeduncles5.15
CiliaryGanglion9.6
CingulateCortex11.55
Colorectaladenocarcinoma89.3
DorsalRootGanglion9.45
FetalThyroid29.35
Fetalbrain12.95
Fetalliver14.15
Fetallung41.65
GlobusPallidus8.45
Heart24.2
Hypothalamus20.15
Kidney37
Leukemia_chronicMyelogenousK-56217.05
Leukemia_promyelocytic-HL-6010.75
Leukemialymphoblastic(MOLT-4)14.6
Liver58.55
Lung363.3
Lymphnode32.1
Lymphoma_burkitts(Daudi)8.25
Lymphoma_burkitts(Raji)20.95
MedullaOblongata11.85
OccipitalLobe9.55
OlfactoryBulb11.55
Ovary8.9
Pancreas37.6
PancreaticIslet20.65
ParietalLobe6
Pituitary14.95
Placenta109.65
Pons8.5
PrefrontalCortex18.9
Prostate235.65
Salivarygland10.9
SkeletalMuscle12.85
Skin8.25
SmoothMuscle233.7
Spinalcord16.4
SubthalamicNucleus7.65
SuperiorCervicalGanglion6.6
TemporalLobe9.1
Testis24.4
TestisGermCell72.65
TestisIntersitial12.5
TestisLeydigCell10.7
TestisSeminiferousTubule12.8
Thalamus8.55
Thymus105.1
Thyroid130.1
Tongue14.7
Tonsil13.8
Trachea24.05
TrigeminalGanglion9.25
Uterus122.7
UterusCorpus31.1
WholeBlood869.45
Wholebrain22.3
colon90.65
pineal_day30.84
pineal_night30.7
retina73.975
small_intestine63.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P156953
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.93 ± 0.52
Basal Forebrain6.1 ± 0.37
Basal Part of Pons6.44 ± 0.39
Cerebellar Cortex6.56 ± 0.46
Cerebellar Nuclei6.51 ± 0.46
Claustrum5.84 ± 0.63
Epithalamus6.81 ± 0.43
Frontal Lobe6.5 ± 0.41
Globus Pallidus6.64 ± 0.25
Hypothalamus6.69 ± 0.27
Insula6.55 ± 0.33
Limbic Lobe6.41 ± 0.46
Mesencephalon6.4 ± 0.47
Myelencephalon6.34 ± 0.48
Occipital Lobe6.44 ± 0.34
Parietal Lobe6.29 ± 0.42
Pontine Tegmentum6.45 ± 0.49
Striatum6.09 ± 0.33
Subthalamus6.48 ± 0.3
Temporal Lobe6.44 ± 0.45
Thalamus6.34 ± 0.4
White Matter7.09 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Igf2rCBCerebellum39.6
54.4
Igf2rCTXCerebral cortex56.05
44.56
Igf2rHIPHippocampal region30.76
41.03
Igf2rHPFHippocampal formation31.67
35.9
Igf2rHYHypothalamus27.72
23.55
Igf2rLSXLateral septal complex30.98
23.87
Igf2rMBMidbrain30.38
29.08
Igf2rMYMedulla43.7
51.76
Igf2rOLFOlfactory bulb51.63
45.5
Igf2rPPons35.72
40.8
Igf2rPALPallidum24.81
24.43
Igf2rRHPRetrohippocampal region33.54
29.21
Igf2rsAMYStriatum-like amygdalar nuclei29.73
23.4
Igf2rSTRStriatum27.77
21.67
Igf2rSTRdStriatum dorsal region25.54
20.24
Igf2rSTRvStriatum ventral region33.34
24
Igf2rTHThalamus35.25
30.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000885 17 1957 1973 CDEDEDIGRPQVFSEVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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