AutismKB 2.0

Annotation Detail for IGFBP4


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Basic Information Top
Gene Symbol:IGFBP4 ( BP-4,HT29-IGFBP,IBP4,IGFBP-4 )
Gene Full Name: insulin-like growth factor binding protein 4
Band: 17q21.2
Quick LinksEntrez ID:3487; OMIM: 146733; Uniprot ID:IBP4_HUMAN; ENSEMBL ID: ENSG00000141753; HGNC ID: 5473
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus65 / 564012115
neonate5 / 31097160
infant2 / 2362084
juvenile3 / 5555653
adult863 / 1939121445
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor69 / 94178732
cervical tumor0 / 343660 
chondrosarcoma58 / 82823700
colorectal tumor22 / 114246192
esophageal tumor0 / 172900 
gastrointestinal tumor190 / 1193691591
germ cell tumor5 / 26384518
glioma45 / 106883421
head and neck tumor28 / 136302205
kidney tumor8 / 68959116
leukemia3 / 9584231
liver tumor15 / 96359155
lung tumor55 / 103127533
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal620 / 3360307184
ovarian tumor14 / 76682182
pancreatic tumor30 / 104616286
primitive neuroectodermal tumor of the CNS31 / 125680246
prostate cancer23 / 102680223
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor61 / 125191487
uterine tumor25 / 90257276
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood2 / 12347816
bone29 / 71655404
bone marrow24 / 48801491
brain87 / 110098979
cervix0 / 481710 
connective tissue15 / 149255100
ear3 / 16212185
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye50 / 211054236
heart18 / 89626200
intestine47 / 234472200
kidney18 / 21177784
larynx5 / 24145207
liver35 / 207743168
lung181 / 336974537
lymph2 / 4427045
lymph node1 / 9161010
mammary gland211 / 1532711376
mouth1 / 6705214
muscle2 / 10771518
nerve8 / 15768507
ovary18 / 102051176
pancreas40 / 214812186
parathyroid0 / 205390 
pharynx7 / 41328169
pituitary gland2 / 16585120
placenta74 / 280825263
prostate40 / 189345211
salivary gland7 / 20155347
skin21 / 21057499
spleen4 / 5395274
stomach191 / 966191976
testis12 / 33044236
thymus1 / 8113112
thyroid15 / 47473315
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord5 / 13680365
uterus42 / 232878180
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201508_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.65
Adipocyte1261.65
AdrenalCortex204.65
Adrenalgland146.75
Amygdala6.35
Appendix385
AtrioventricularNode329.3
BDCA4+_DentriticCells4.9
Bonemarrow4.35
BronchialEpithelialCells31.95
CD105+_Endothelial21.75
CD14+_Monocytes5.55
CD19+_BCells(neg._sel.)29.3
CD33+_Myeloid5.9
CD34+6.15
CD4+_Tcells4.8
CD56+_NKCells12.3
CD71+_EarlyErythroid8.65
CD8+_Tcells4.25
CardiacMyocytes311.65
Caudatenucleus4.35
Cerebellum3.5
CerebellumPeduncles4.9
CiliaryGanglion122.6
CingulateCortex4.4
Colorectaladenocarcinoma423.2
DorsalRootGanglion273.6
FetalThyroid719.6
Fetalbrain28.2
Fetalliver71.7
Fetallung678.05
GlobusPallidus3.15
Heart147.75
Hypothalamus5.35
Kidney508.95
Leukemia_chronicMyelogenousK-562297.75
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.5
Liver1036.1
Lung451
Lymphnode173.9
Lymphoma_burkitts(Daudi)5.5
Lymphoma_burkitts(Raji)6.1
MedullaOblongata4.3
OccipitalLobe3.95
OlfactoryBulb178.6
Ovary2449.8
Pancreas42.6
PancreaticIslet463.15
ParietalLobe4.7
Pituitary33.15
Placenta618.75
Pons18
PrefrontalCortex42.45
Prostate223.95
Salivarygland75.95
SkeletalMuscle55.8
Skin131.15
SmoothMuscle1919.7
Spinalcord13.75
SubthalamicNucleus5
SuperiorCervicalGanglion21.85
TemporalLobe8.55
Testis60.45
TestisGermCell168.15
TestisIntersitial78.7
TestisLeydigCell69.35
TestisSeminiferousTubule108.7
Thalamus4.85
Thymus70.75
Thyroid1044.1
Tongue73.9
Tonsil23
Trachea132.35
TrigeminalGanglion54.25
Uterus561.2
UterusCorpus991.1
WholeBlood4.85
Wholebrain10.5
colon143.15
pineal_day41.84
pineal_night44.46
retina590.175
small_intestine173.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14654_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.46 ± 0.96
Basal Forebrain2.2 ± 0.3
Basal Part of Pons1.75 ± 0.69
Cerebellar Cortex2.14 ± 0.74
Cerebellar Nuclei2.1 ± 0.61
Claustrum2.59 ± 0.82
Epithalamus1.74 ± 0.81
Frontal Lobe2.01 ± 0.72
Globus Pallidus2.36 ± 0.62
Hypothalamus1.8 ± 0.77
Insula2.16 ± 0.55
Limbic Lobe2.04 ± 0.81
Mesencephalon2.09 ± 0.69
Myelencephalon2.1 ± 0.72
Occipital Lobe1.81 ± 0.66
Parietal Lobe2 ± 0.83
Pontine Tegmentum2.07 ± 0.78
Striatum1.96 ± 0.84
Subthalamus2.19 ± 0.55
Temporal Lobe2.01 ± 0.77
Thalamus1.97 ± 0.77
White Matter1.91 ± 0.85
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Igfbp4CBCerebellum10.33
16.87
Igfbp4CTXCerebral cortex82.67
98.74
Igfbp4HIPHippocampal region57.87
100
Igfbp4HPFHippocampal formation57.75
87.99
Igfbp4HYHypothalamus5.83
5.42
Igfbp4LSXLateral septal complex9.06
45.93
Igfbp4MBMidbrain10.99
11.85
Igfbp4MYMedulla6.63
9.41
Igfbp4OLFOlfactory bulb39.1
43.46
Igfbp4PPons7.5
8.81
Igfbp4PALPallidum4.65
7.12
Igfbp4RHPRetrohippocampal region57.11
60.83
Igfbp4sAMYStriatum-like amygdalar nuclei15.17
18.09
Igfbp4STRStriatum24.31
32.64
Igfbp4STRdStriatum dorsal region24.91
35.48
Igfbp4STRvStriatum ventral region26.85
27.88
Igfbp4THThalamus9.14
11.35
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009912 17 164 180 EDARPVPQGSCQSELHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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