AutismKB 2.0

Annotation Detail for IGFBP5


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Basic Information Top
Gene Symbol:IGFBP5 ( IBP5 )
Gene Full Name: insulin-like growth factor binding protein 5
Band: 2q35
Quick LinksEntrez ID:3488; OMIM: 146734; Uniprot ID:IBP5_HUMAN; ENSEMBL ID: ENSG00000115461; HGNC ID: 5474
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body61 / 70761862
blastocyst30 / 62319481
fetus93 / 564012164
neonate2 / 3109764
infant6 / 23620254
juvenile4 / 5555671
adult470 / 1939121242
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor7 / 12794547
bladder carcinoma1 / 1747557
breast (mammary gland) tumor24 / 94178254
cervical tumor1 / 3436629
chondrosarcoma81 / 82823977
colorectal tumor9 / 11424678
esophageal tumor2 / 17290115
gastrointestinal tumor10 / 11936983
germ cell tumor49 / 263845185
glioma31 / 106883290
head and neck tumor65 / 136302476
kidney tumor10 / 68959145
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor14 / 103127135
lymphoma1 / 7175513
non-neoplasia16 / 97250164
normal752 / 3360307223
ovarian tumor11 / 76682143
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue9 / 13106686
adrenal gland13 / 33197391
ascites0 / 400150 
bladder3 / 29757100
blood0 / 1234780 
bone7 / 7165597
bone marrow1 / 4880120
brain203 / 1100989184
cervix2 / 4817141
connective tissue37 / 149255247
ear6 / 16212370
embryonic tissue100 / 215722463
esophagus3 / 20209148
eye98 / 211054464
heart22 / 89626245
intestine33 / 234472140
kidney37 / 211777174
larynx4 / 24145165
liver3 / 20774314
lung121 / 336974359
lymph0 / 442700 
lymph node1 / 9161010
mammary gland52 / 153271339
mouth35 / 67052521
muscle25 / 107715232
nerve9 / 15768570
ovary23 / 102051225
pancreas41 / 214812190
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta59 / 280825210
prostate14 / 18934573
salivary gland6 / 20155297
skin21 / 21057499
spleen1 / 5395218
stomach13 / 96619134
testis58 / 330442175
thymus32 / 81131394
thyroid33 / 47473695
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord1 / 1368073
uterus96 / 232878412
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203424_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte5.45
AdrenalCortex4.6
Adrenalgland4.3
Amygdala4.25
Appendix4.45
AtrioventricularNode3.25
BDCA4+_DentriticCells4.35
Bonemarrow3.95
BronchialEpithelialCells3.9
CD105+_Endothelial4
CD14+_Monocytes4.25
CD19+_BCells(neg._sel.)4.25
CD33+_Myeloid5.1
CD34+5.05
CD4+_Tcells4.35
CD56+_NKCells4.75
CD71+_EarlyErythroid3.75
CD8+_Tcells3.85
CardiacMyocytes4.95
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.55
CiliaryGanglion2.85
CingulateCortex4.1
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.5
FetalThyroid5.3
Fetalbrain4.05
Fetalliver3.4
Fetallung3.35
GlobusPallidus2.95
Heart5.05
Hypothalamus4.35
Kidney4.1
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.2
Liver5.25
Lung4.5
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)5.5
MedullaOblongata3.7
OccipitalLobe3.6
OlfactoryBulb3.55
Ovary6.6
Pancreas3.2
PancreaticIslet4.35
ParietalLobe4.25
Pituitary4.75
Placenta4.45
Pons3.8
PrefrontalCortex4.95
Prostate4.8
Salivarygland3.2
SkeletalMuscle4.55
Skin3.1
SmoothMuscle4.55
Spinalcord4.3
SubthalamicNucleus3.65
SuperiorCervicalGanglion5.35
TemporalLobe3.65
Testis3.5
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell3.95
TestisSeminiferousTubule3.45
Thalamus4.1
Thymus3.25
Thyroid5.55
Tongue4
Tonsil3.95
Trachea4.2
TrigeminalGanglion6.05
Uterus4.35
UterusCorpus4
WholeBlood4.35
Wholebrain3.4
colon4.1
pineal_day5.1
pineal_night6.14
retina5.45
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P376497
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.66 ± 0.53
Basal Forebrain5.03 ± 0.4
Basal Part of Pons4.37 ± 0.46
Cerebellar Cortex4.97 ± 0.74
Cerebellar Nuclei4.83 ± 0.45
Claustrum4.38 ± 0.72
Epithalamus5.94 ± 0.61
Frontal Lobe4.78 ± 0.6
Globus Pallidus5.16 ± 0.6
Hypothalamus4.51 ± 0.86
Insula5.1 ± 0.7
Limbic Lobe5.19 ± 0.62
Mesencephalon4.78 ± 0.66
Myelencephalon4.99 ± 0.67
Occipital Lobe4.56 ± 0.66
Parietal Lobe4.75 ± 0.59
Pontine Tegmentum5.03 ± 0.62
Striatum5.46 ± 0.73
Subthalamus4.22 ± 0.34
Temporal Lobe5.08 ± 0.55
Thalamus4.63 ± 0.48
White Matter5.94 ± 0.9
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Igfbp5CBCerebellum100
100
Igfbp5CTXCerebral cortex65.8
64.72
Igfbp5HIPHippocampal region81.26
100
Igfbp5HPFHippocampal formation80.36
100
Igfbp5HYHypothalamus52.95
53.63
Igfbp5LSXLateral septal complex54.99
58.22
Igfbp5MBMidbrain46.43
55.98
Igfbp5MYMedulla38.47
57.4
Igfbp5OLFOlfactory bulb78.85
94.7
Igfbp5PPons39.2
63.48
Igfbp5PALPallidum27.2
27.7
Igfbp5RHPRetrohippocampal region80.14
100
Igfbp5sAMYStriatum-like amygdalar nuclei35.64
34.36
Igfbp5STRStriatum28.57
32.41
Igfbp5STRdStriatum dorsal region23.03
30.44
Igfbp5STRvStriatum ventral region29.88
23.97
Igfbp5THThalamus75.14
98.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IBP5_HUMAN_185 9 185 193 QESEQGPCR PRIDE
PAp00136567 12 165 176 FVGGAENTAHPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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