AutismKB 2.0

Annotation Detail for IGFBP7


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Basic Information Top
Gene Symbol:IGFBP7 ( AGM,FSTL2,IBP-7,IGFBP-7,IGFBP-7v,IGFBPRP1,MAC25,PSF,TAF )
Gene Full Name: insulin-like growth factor binding protein 7
Band: 4q12
Quick LinksEntrez ID:3490; OMIM: 602867; Uniprot ID:IBP7_HUMAN; ENSEMBL ID: ENSG00000163453; HGNC ID: 5476
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst2 / 6231932
fetus47 / 56401283
neonate1 / 3109732
infant6 / 23620254
juvenile3 / 5555653
adult283 / 1939121145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma14 / 82823169
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor1 / 2638453
glioma13 / 106883121
head and neck tumor76 / 136302557
kidney tumor12 / 68959174
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma5 / 7175569
non-neoplasia7 / 9725071
normal462 / 3360307137
ovarian tumor8 / 76682104
pancreatic tumor38 / 104616363
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor24 / 90257265
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone8 / 71655111
bone marrow11 / 48801225
brain163 / 1100989148
cervix1 / 4817120
connective tissue8 / 14925553
ear5 / 16212308
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye58 / 211054274
heart13 / 89626145
intestine45 / 234472191
kidney29 / 211777136
larynx73 / 241453023
liver8 / 20774338
lung37 / 336974109
lymph0 / 442700 
lymph node5 / 9161054
mammary gland5 / 15327132
mouth1 / 6705214
muscle4 / 10771537
nerve5 / 15768317
ovary5 / 10205148
pancreas124 / 214812577
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta22 / 28082578
prostate9 / 18934547
salivary gland1 / 2015549
skin20 / 21057494
spleen2 / 5395237
stomach17 / 96619175
testis41 / 330442124
thymus3 / 8113136
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus33 / 232878141
vascular17 / 51780328
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201163_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.5
Adipocyte983.45
AdrenalCortex542.55
Adrenalgland1546.6
Amygdala959.75
Appendix1220.95
AtrioventricularNode767.85
BDCA4+_DentriticCells26.1
Bonemarrow206.6
BronchialEpithelialCells1371.05
CD105+_Endothelial215.3
CD14+_Monocytes58.5
CD19+_BCells(neg._sel.)12.45
CD33+_Myeloid345.7
CD34+799.35
CD4+_Tcells8.8
CD56+_NKCells711.3
CD71+_EarlyErythroid10.35
CD8+_Tcells6.85
CardiacMyocytes5231.8
Caudatenucleus205.2
Cerebellum159.25
CerebellumPeduncles171.15
CiliaryGanglion594.1
CingulateCortex168.9
Colorectaladenocarcinoma726.35
DorsalRootGanglion664.85
FetalThyroid1402.9
Fetalbrain181.1
Fetalliver214.3
Fetallung780.35
GlobusPallidus114.25
Heart6045.9
Hypothalamus610.15
Kidney2613.65
Leukemia_chronicMyelogenousK-5628.8
Leukemia_promyelocytic-HL-608.6
Leukemialymphoblastic(MOLT-4)6.75
Liver998.35
Lung1965
Lymphnode1699
Lymphoma_burkitts(Daudi)15.15
Lymphoma_burkitts(Raji)18.75
MedullaOblongata84.85
OccipitalLobe168.6
OlfactoryBulb1102.95
Ovary511.6
Pancreas553.7
PancreaticIslet1187.6
ParietalLobe87.3
Pituitary691.9
Placenta706.85
Pons49.75
PrefrontalCortex663.65
Prostate3093.8
Salivarygland427.6
SkeletalMuscle61.45
Skin426.55
SmoothMuscle3242.05
Spinalcord780.65
SubthalamicNucleus114.65
SuperiorCervicalGanglion243.9
TemporalLobe127.6
Testis1816.6
TestisGermCell1586.35
TestisIntersitial949.45
TestisLeydigCell1067.45
TestisSeminiferousTubule1392.05
Thalamus410.85
Thymus729
Thyroid8123.6
Tongue276.65
Tonsil523.5
Trachea744.4
TrigeminalGanglion665.85
Uterus2996.55
UterusCorpus502.9
WholeBlood56.65
Wholebrain567.15
colon3110.95
pineal_day771
pineal_night2346.32
retina5720
small_intestine5072.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10217_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.4 ± 0.42
Basal Forebrain8.73 ± 0.19
Basal Part of Pons8.87 ± 0.36
Cerebellar Cortex8.48 ± 0.33
Cerebellar Nuclei9.74 ± 0.34
Claustrum8.11 ± 0.47
Epithalamus9.68 ± 0.33
Frontal Lobe9.01 ± 0.49
Globus Pallidus10.3 ± 0.34
Hypothalamus8.94 ± 0.56
Insula8.93 ± 0.23
Limbic Lobe8.71 ± 0.54
Mesencephalon8.99 ± 0.51
Myelencephalon9.1 ± 0.52
Occipital Lobe9.15 ± 0.48
Parietal Lobe8.82 ± 0.58
Pontine Tegmentum9.22 ± 0.5
Striatum9.83 ± 0.52
Subthalamus9.34 ± 0.32
Temporal Lobe8.9 ± 0.36
Thalamus9.22 ± 0.47
White Matter9.24 ± 1.01
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IBP7_HUMAN_205 16 205 220 TELLPGDRDNLAIQTR PRIDE
IBP7_HUMAN_240 22 240 261 EDAGEYECHASNSQGQASASAK PRIDE
PAp00009222 17 98 114 AGAAAGGPGVSGVCVCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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