AutismKB 2.0

Annotation Detail for TICAM2


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Basic Information Top
Gene Symbol:TICAM2 ( MGC129876,MGC129877,TICAM-2,TIRAP3,TIRP,TRAM )
Gene Full Name: toll-like receptor adaptor molecule 2
Band: 5q22.3
Quick LinksEntrez ID:353376; OMIM: 608321; Uniprot ID:TCAM2_HUMAN; ENSEMBL ID: ENSG00000243414; HGNC ID: 21354
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst3 / 6231948
fetus54 / 56401295
neonate9 / 31097289
infant1 / 2362042
juvenile4 / 5555671
adult146 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor26 / 26384598
glioma6 / 10688356
head and neck tumor20 / 136302146
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia12 / 97250123
normal421 / 3360307125
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder3 / 29757100
blood8 / 12347864
bone4 / 7165555
bone marrow6 / 48801122
brain242 / 1100989219
cervix1 / 4817120
connective tissue17 / 149255113
ear2 / 16212123
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye10 / 21105447
heart4 / 8962644
intestine13 / 23447255
kidney20 / 21177794
larynx0 / 241450 
liver12 / 20774357
lung16 / 33697447
lymph0 / 442700 
lymph node10 / 91610109
mammary gland9 / 15327158
mouth23 / 67052343
muscle3 / 10771527
nerve1 / 1576863
ovary1 / 1020519
pancreas24 / 214812111
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta45 / 280825160
prostate6 / 18934531
salivary gland0 / 201550 
skin18 / 21057485
spleen5 / 5395292
stomach2 / 9661920
testis66 / 330442199
thymus21 / 81131258
thyroid0 / 474730 
tonsil0 / 169990 
trachea120 / 524132289
umbilical cord1 / 1368073
uterus43 / 232878184
vascular5 / 5178096
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8781_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.79 ± 0.25
Basal Forebrain6.87 ± 0.15
Basal Part of Pons6.75 ± 0.24
Cerebellar Cortex7.02 ± 0.2
Cerebellar Nuclei6.88 ± 0.18
Claustrum6.57 ± 0.32
Epithalamus7.07 ± 0.34
Frontal Lobe6.81 ± 0.24
Globus Pallidus7.1 ± 0.35
Hypothalamus6.83 ± 0.26
Insula6.78 ± 0.21
Limbic Lobe6.86 ± 0.22
Mesencephalon6.85 ± 0.29
Myelencephalon6.87 ± 0.3
Occipital Lobe7.1 ± 0.29
Parietal Lobe6.83 ± 0.24
Pontine Tegmentum6.93 ± 0.3
Striatum7.07 ± 0.32
Subthalamus6.88 ± 0.21
Temporal Lobe6.81 ± 0.23
Thalamus6.88 ± 0.28
White Matter7.89 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ticam2CBCerebellum100
100
Ticam2CTXCerebral cortex100
100
Ticam2HIPHippocampal region100
100
Ticam2HPFHippocampal formation100
100
Ticam2HYHypothalamus71.66
63.97
Ticam2LSXLateral septal complex100
100
Ticam2MBMidbrain91.12
92.35
Ticam2MYMedulla95.17
100
Ticam2OLFOlfactory bulb100
100
Ticam2PPons72.22
74
Ticam2PALPallidum82.81
87.75
Ticam2RHPRetrohippocampal region100
100
Ticam2sAMYStriatum-like amygdalar nuclei100
100
Ticam2STRStriatum100
100
Ticam2STRdStriatum dorsal region100
100
Ticam2STRvStriatum ventral region100
100
Ticam2THThalamus98.58
99.76
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018