AutismKB 2.0

Annotation Detail for POLN


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Basic Information Top
Gene Symbol:POLN ( POL4P )
Gene Full Name: polymerase (DNA directed) nu
Band: 4p16.3
Quick LinksEntrez ID:353497; OMIM: 610887; Uniprot ID:DPOLN_HUMAN; ENSEMBL ID: ENSG00000130997; HGNC ID: 18870
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult13 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal15 / 33603074
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16528_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.14 ± 0.49
Basal Forebrain3.58 ± 0.44
Basal Part of Pons3.5 ± 0.28
Cerebellar Cortex4.37 ± 0.33
Cerebellar Nuclei3.48 ± 0.5
Claustrum3.53 ± 0.62
Epithalamus3.56 ± 0.57
Frontal Lobe3.74 ± 0.53
Globus Pallidus3.07 ± 0.71
Hypothalamus3.7 ± 0.43
Insula3.76 ± 0.47
Limbic Lobe3.9 ± 0.57
Mesencephalon3.81 ± 0.58
Myelencephalon3.76 ± 0.53
Occipital Lobe4.07 ± 0.58
Parietal Lobe3.85 ± 0.5
Pontine Tegmentum3.86 ± 0.65
Striatum3.52 ± 0.64
Subthalamus3.63 ± 0.79
Temporal Lobe3.9 ± 0.51
Thalamus3.69 ± 0.55
White Matter3.54 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PolnCBCerebellum0
0
PolnCTXCerebral cortex0
0
PolnHIPHippocampal region0
0
PolnHPFHippocampal formation0
0
PolnHYHypothalamus0
0
PolnLSXLateral septal complex0
0
PolnMBMidbrain0
0
PolnMYMedulla0
0
PolnOLFOlfactory bulb0
0
PolnPPons0
0
PolnPALPallidum0
0
PolnRHPRetrohippocampal region0
0
PolnsAMYStriatum-like amygdalar nuclei0
0
PolnSTRStriatum0
0
PolnSTRdStriatum dorsal region0
0
PolnSTRvStriatum ventral region0
0
PolnTHThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018