AutismKB 2.0

Annotation Detail for IL1B


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Basic Information Top
Gene Symbol:IL1B ( IL-1,IL1-BETA,IL1F2 )
Gene Full Name: interleukin 1, beta
Band: 2q14.1
Quick LinksEntrez ID:3553; OMIM: 147720; Uniprot ID:IL1B_HUMAN; ENSEMBL ID: ENSG00000125538; HGNC ID: 5992
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant9 / 23620381
juvenile0 / 555560 
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor4 / 17290231
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia9 / 9584293
liver tumor22 / 96359228
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal386 / 3360307114
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood30 / 123478242
bone0 / 716550 
bone marrow2 / 4880140
brain12 / 110098910
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus4 / 20209197
eye2 / 2110549
heart0 / 896260 
intestine5 / 23447221
kidney0 / 2117770 
larynx0 / 241450 
liver22 / 207743105
lung32 / 33697494
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin8 / 21057437
spleen3 / 5395255
stomach1 / 9661910
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular277 / 517805349
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205067_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.3
AdrenalCortex4.65
Adrenalgland3.8
Amygdala4.55
Appendix5.55
AtrioventricularNode6.75
BDCA4+_DentriticCells300.2
Bonemarrow4.25
BronchialEpithelialCells624.85
CD105+_Endothelial4.35
CD14+_Monocytes24.5
CD19+_BCells(neg._sel.)4.4
CD33+_Myeloid1360.75
CD34+248.3
CD4+_Tcells4.55
CD56+_NKCells5
CD71+_EarlyErythroid3.95
CD8+_Tcells4
CardiacMyocytes31.3
Caudatenucleus4.2
Cerebellum4.1
CerebellumPeduncles5.15
CiliaryGanglion4.05
CingulateCortex4.45
Colorectaladenocarcinoma4.35
DorsalRootGanglion4.65
FetalThyroid4.1
Fetalbrain13.15
Fetalliver3.75
Fetallung15.55
GlobusPallidus3.5
Heart5.8
Hypothalamus4.7
Kidney3.8
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.35
Liver5.85
Lung4.85
Lymphnode4
Lymphoma_burkitts(Daudi)5.3
Lymphoma_burkitts(Raji)6.05
MedullaOblongata3.95
OccipitalLobe3.8
OlfactoryBulb3.45
Ovary3.05
Pancreas3.55
PancreaticIslet4.8
ParietalLobe4.55
Pituitary5.1
Placenta4.55
Pons4.2
PrefrontalCortex5.25
Prostate5
Salivarygland4.75
SkeletalMuscle5.95
Skin7.1
SmoothMuscle4536.55
Spinalcord5.45
SubthalamicNucleus4.1
SuperiorCervicalGanglion9.55
TemporalLobe4.25
Testis3.85
TestisGermCell3.65
TestisIntersitial3.6
TestisLeydigCell4.75
TestisSeminiferousTubule3.75
Thalamus4.3
Thymus3.35
Thyroid5.3
Tongue5.25
Tonsil6.05
Trachea4.9
TrigeminalGanglion5.6
Uterus4.05
UterusCorpus7
WholeBlood201.15
Wholebrain3.65
colon4.15
pineal_day5.22
pineal_night5.08
retina6
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15675_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.49 ± 0.97
Basal Forebrain3.92 ± 0.96
Basal Part of Pons4.2 ± 0.56
Cerebellar Cortex3.48 ± 0.55
Cerebellar Nuclei4.94 ± 0.27
Claustrum3.8 ± 0.59
Epithalamus5.72 ± 0.58
Frontal Lobe3.77 ± 0.91
Globus Pallidus5.56 ± 0.37
Hypothalamus4.29 ± 1.02
Insula4.2 ± 0.53
Limbic Lobe4.02 ± 0.76
Mesencephalon3.83 ± 0.76
Myelencephalon4.05 ± 0.81
Occipital Lobe3.51 ± 0.58
Parietal Lobe3.78 ± 0.75
Pontine Tegmentum3.81 ± 0.9
Striatum4.13 ± 0.55
Subthalamus4.19 ± 0.26
Temporal Lobe4.22 ± 0.8
Thalamus3.77 ± 0.79
White Matter5.71 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Il1bCBCerebellum0.65
1.62
Il1bCTXCerebral cortex0.41
0.31
Il1bHIPHippocampal region0.22
0.32
Il1bHPFHippocampal formation0.25
0.29
Il1bHYHypothalamus0.5
0.29
Il1bLSXLateral septal complex0.12
0.04
Il1bMBMidbrain0.33
0.35
Il1bMYMedulla0.57
0.5
Il1bOLFOlfactory bulb1.25
0.81
Il1bPPons0.41
0.33
Il1bPALPallidum0.21
0.24
Il1bRHPRetrohippocampal region0.27
0.18
Il1bsAMYStriatum-like amygdalar nuclei0.6
0.96
Il1bSTRStriatum0.41
0.48
Il1bSTRdStriatum dorsal region0.3
0.42
Il1bSTRvStriatum ventral region0.65
0.44
Il1bTHThalamus0.36
0.76
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IL1B_HUMAN_132 11 132 142 SLVMSGPYELK PRIDE
IL1B_HUMAN_181 23 181 203 NLYLSCVLKDDKPTLQLESVDPK PRIDE
IL1B_HUMAN_181 9 181 189 NLYLSCVLK PRIDE
IL1B_HUMAN_190 14 190 203 DDKPTLQLESVDPK PRIDE
IL1B_HUMAN_254 15 254 268 GGQDITDFTMQFVSS PRIDE
IL1B_HUMAN_30 21 30 50 QMKCSFQDLDLCPLDGGIQLR PRIDE
IL1B_HUMAN_33 18 33 50 CSFQDLDLCPLDGGIQLR PRIDE
IL1B_HUMAN_62 11 62 72 QAASVVVAMDK PRIDE
IL1B_HUMAN_62 13 62 74 QAASVVVAMDKLR PRIDE
PAp00009671 18 34 51 CSFQDLDLCPLDGGIQLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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