AutismKB 2.0

Annotation Detail for IL2RB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL2RB ( CD122,P70-75 )
Gene Full Name: interleukin 2 receptor, beta
Band: 22q12.3
Quick LinksEntrez ID:3560; OMIM: 146710; Uniprot ID:IL2RB_HUMAN; ENSEMBL ID: ENSG00000100385; HGNC ID: 6009
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal118 / 336030735
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood13 / 123478105
bone0 / 716550 
bone marrow1 / 4880120
brain8 / 11009897
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine1 / 2344724
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node3 / 9161032
mammary gland5 / 15327132
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta59 / 280825210
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen13 / 53952240
stomach1 / 9661910
testis3 / 3304429
thymus10 / 81131123
thyroid0 / 474730 
tonsil2 / 16999117
trachea14 / 52413267
umbilical cord0 / 136800 
uterus19 / 23287881
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205291_at
Cell line Expression level Expression bar
721_B_lymphoblasts407.35
Adipocyte5.7
AdrenalCortex5.6
Adrenalgland4.55
Amygdala5.85
Appendix8.95
AtrioventricularNode7.85
BDCA4+_DentriticCells13.95
Bonemarrow15.25
BronchialEpithelialCells4.95
CD105+_Endothelial5.55
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid6.9
CD34+6.7
CD4+_Tcells278.85
CD56+_NKCells3023.65
CD71+_EarlyErythroid5.25
CD8+_Tcells471
CardiacMyocytes6.7
Caudatenucleus4.9
Cerebellum4.4
CerebellumPeduncles5.95
CiliaryGanglion6.1
CingulateCortex4.7
Colorectaladenocarcinoma5.75
DorsalRootGanglion8.75
FetalThyroid5.3
Fetalbrain5.5
Fetalliver10.05
Fetallung5.05
GlobusPallidus3.9
Heart8.65
Hypothalamus5.6
Kidney4.55
Leukemia_chronicMyelogenousK-5624.7
Leukemia_promyelocytic-HL-604.9
Leukemialymphoblastic(MOLT-4)4.2
Liver11.05
Lung13.25
Lymphnode47.35
Lymphoma_burkitts(Daudi)6.85
Lymphoma_burkitts(Raji)8.25
MedullaOblongata4.25
OccipitalLobe4.05
OlfactoryBulb4.3
Ovary6.7
Pancreas4.6
PancreaticIslet6
ParietalLobe4.5
Pituitary6.4
Placenta73.35
Pons7
PrefrontalCortex6.75
Prostate7.6
Salivarygland9.7
SkeletalMuscle7.75
Skin9.75
SmoothMuscle5.9
Spinalcord5.05
SubthalamicNucleus4.3
SuperiorCervicalGanglion17.5
TemporalLobe4.9
Testis4.75
TestisGermCell4.6
TestisIntersitial7.15
TestisLeydigCell6
TestisSeminiferousTubule4.8
Thalamus4.2
Thymus12
Thyroid8.1
Tongue7.45
Tonsil15.65
Trachea4.85
TrigeminalGanglion5.65
Uterus7
UterusCorpus6.95
WholeBlood50.05
Wholebrain4.5
colon5.55
pineal_day6.58
pineal_night6.78
retina6.825
small_intestine5.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17061_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.7 ± 0.51
Basal Forebrain4.53 ± 0.3
Basal Part of Pons4.66 ± 0.21
Cerebellar Cortex4 ± 0.53
Cerebellar Nuclei4.85 ± 0.43
Claustrum5.01 ± 0.72
Epithalamus3.97 ± 0.76
Frontal Lobe4.51 ± 0.61
Globus Pallidus4.78 ± 0.37
Hypothalamus4.52 ± 0.53
Insula4.39 ± 0.38
Limbic Lobe4.61 ± 0.55
Mesencephalon4.49 ± 0.5
Myelencephalon4.53 ± 0.65
Occipital Lobe4.31 ± 0.65
Parietal Lobe4.51 ± 0.63
Pontine Tegmentum4.4 ± 0.72
Striatum4.5 ± 0.62
Subthalamus4.53 ± 0.26
Temporal Lobe4.39 ± 0.59
Thalamus4.58 ± 0.51
White Matter4.21 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Il2rbCBCerebellum61.59
97.01
Il2rbCTXCerebral cortex29.9
21.91
Il2rbHIPHippocampal region24.24
27.06
Il2rbHPFHippocampal formation28.36
27.4
Il2rbHYHypothalamus13.04
10.7
Il2rbLSXLateral septal complex3.21
2.52
Il2rbMBMidbrain4.34
5.12
Il2rbMYMedulla20.5
21.36
Il2rbOLFOlfactory bulb36.75
30.06
Il2rbPPons13.68
15.73
Il2rbPALPallidum8.45
6.81
Il2rbRHPRetrohippocampal region36.92
28.94
Il2rbsAMYStriatum-like amygdalar nuclei12.23
8.29
Il2rbSTRStriatum13.92
10.07
Il2rbSTRdStriatum dorsal region12.93
9.11
Il2rbSTRvStriatum ventral region23.91
17.86
Il2rbTHThalamus4.09
3.05
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved