AutismKB 2.0

Annotation Detail for IL4R


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Basic Information Top
Gene Symbol:IL4R ( CD124,IL4RA )
Gene Full Name: interleukin 4 receptor
Band: 16p12.1
Quick LinksEntrez ID:3566; OMIM: 147781; Uniprot ID:IL4RA_HUMAN; ENSEMBL ID: ENSG00000077238; HGNC ID: 6015
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma11 / 82823132
colorectal tumor22 / 114246192
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor9 / 13630266
kidney tumor6 / 6895987
leukemia9 / 9584293
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma20 / 71755278
non-neoplasia2 / 9725020
normal112 / 336030733
ovarian tumor3 / 7668239
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites5 / 40015124
bladder1 / 2975733
blood8 / 12347864
bone6 / 7165583
bone marrow1 / 4880120
brain15 / 110098913
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine28 / 234472119
kidney8 / 21177737
larynx3 / 24145124
liver7 / 20774333
lung24 / 33697471
lymph17 / 44270384
lymph node15 / 91610163
mammary gland6 / 15327139
mouth6 / 6705289
muscle11 / 107715102
nerve0 / 157680 
ovary4 / 10205139
pancreas13 / 21481260
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta3 / 28082510
prostate9 / 18934547
salivary gland0 / 201550 
skin2 / 2105749
spleen3 / 5395255
stomach2 / 9661920
testis10 / 33044230
thymus6 / 8113173
thyroid0 / 474730 
tonsil10 / 16999588
trachea2 / 5241338
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203233_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.6
Adipocyte5.8
AdrenalCortex8.8
Adrenalgland5.05
Amygdala5.7
Appendix6.05
AtrioventricularNode5.15
BDCA4+_DentriticCells29.3
Bonemarrow8.95
BronchialEpithelialCells14.85
CD105+_Endothelial5.8
CD14+_Monocytes31.05
CD19+_BCells(neg._sel.)926.9
CD33+_Myeloid23.45
CD34+7.45
CD4+_Tcells67.45
CD56+_NKCells15.05
CD71+_EarlyErythroid5.4
CD8+_Tcells17.8
CardiacMyocytes12.9
Caudatenucleus5.2
Cerebellum4.65
CerebellumPeduncles6.55
CiliaryGanglion10.25
CingulateCortex5.95
Colorectaladenocarcinoma5.75
DorsalRootGanglion4.4
FetalThyroid6
Fetalbrain5.7
Fetalliver6
Fetallung12.2
GlobusPallidus4.2
Heart7.5
Hypothalamus5.95
Kidney4.65
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-605.2
Leukemialymphoblastic(MOLT-4)4.45
Liver9.05
Lung31.7
Lymphnode19.6
Lymphoma_burkitts(Daudi)61.05
Lymphoma_burkitts(Raji)8.85
MedullaOblongata5.25
OccipitalLobe5.15
OlfactoryBulb4.8
Ovary3.9
Pancreas4.65
PancreaticIslet6.35
ParietalLobe6.05
Pituitary6.8
Placenta9.6
Pons5.5
PrefrontalCortex7.3
Prostate13.4
Salivarygland7.85
SkeletalMuscle6.5
Skin5.4
SmoothMuscle16.05
Spinalcord6.25
SubthalamicNucleus5.3
SuperiorCervicalGanglion7.35
TemporalLobe5.25
Testis5.1
TestisGermCell7.2
TestisIntersitial4.9
TestisLeydigCell5.8
TestisSeminiferousTubule5
Thalamus5.9
Thymus5.3
Thyroid7.4
Tongue5.95
Tonsil24.7
Trachea4.9
TrigeminalGanglion5.7
Uterus11.2
UterusCorpus5.65
WholeBlood73.3
Wholebrain4.6
colon6
pineal_day7.14
pineal_night6.98
retina7.125
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15991_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.34 ± 1.04
Basal Forebrain1.86 ± 0.19
Basal Part of Pons1.69 ± 0.6
Cerebellar Cortex1.72 ± 0.68
Cerebellar Nuclei2.2 ± 0.7
Claustrum2.73 ± 0.76
Epithalamus1.85 ± 0.57
Frontal Lobe1.77 ± 0.65
Globus Pallidus2.59 ± 0.6
Hypothalamus2.02 ± 0.73
Insula2.03 ± 0.66
Limbic Lobe1.89 ± 0.6
Mesencephalon2.04 ± 0.73
Myelencephalon1.96 ± 0.68
Occipital Lobe1.93 ± 0.6
Parietal Lobe1.92 ± 0.73
Pontine Tegmentum1.97 ± 0.68
Striatum2.11 ± 0.58
Subthalamus2.08 ± 0.69
Temporal Lobe1.81 ± 0.69
Thalamus1.88 ± 0.59
White Matter2.46 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Il4raCBCerebellum0
0
Il4raCTXCerebral cortex0
0
Il4raHIPHippocampal region0
0
Il4raHPFHippocampal formation0
0
Il4raHYHypothalamus0
0
Il4raLSXLateral septal complex0
0
Il4raMBMidbrain0
0
Il4raMYMedulla0
0
Il4raOLFOlfactory bulb0
0
Il4raPPons0
0
Il4raPALPallidum0
0
Il4raRHPRetrohippocampal region0
0
Il4rasAMYStriatum-like amygdalar nuclei0
0
Il4raSTRStriatum0
0
Il4raSTRdStriatum dorsal region0
0
Il4raSTRvStriatum ventral region0
0
Il4raTHThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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