AutismKB 2.0

Annotation Detail for IL6ST


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Basic Information Top
Gene Symbol:IL6ST ( CD130,CDW130,DKFZp564F053,GP130,IL-6RB )
Gene Full Name: interleukin 6 signal transducer (gp130, oncostatin M receptor)
Band: 5q11.2
Quick LinksEntrez ID:3572; OMIM: 600694; Uniprot ID:IL6RB_HUMAN; ENSEMBL ID: ENSG00000134352; HGNC ID: 6021
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst0 / 623190 
fetus55 / 56401297
neonate5 / 31097160
infant1 / 2362042
juvenile8 / 55556143
adult222 / 1939121114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor13 / 94178138
cervical tumor2 / 3436658
chondrosarcoma10 / 82823120
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor21 / 26384579
glioma4 / 10688337
head and neck tumor7 / 13630251
kidney tumor6 / 6895987
leukemia2 / 9584220
liver tumor14 / 96359145
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia13 / 97250133
normal367 / 3360307109
ovarian tumor3 / 7668239
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites1 / 4001524
bladder5 / 29757168
blood2 / 12347816
bone7 / 7165597
bone marrow2 / 4880140
brain70 / 110098963
cervix2 / 4817141
connective tissue18 / 149255120
ear4 / 16212246
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye20 / 21105494
heart8 / 8962689
intestine13 / 23447255
kidney24 / 211777113
larynx1 / 2414541
liver34 / 207743163
lung15 / 33697444
lymph0 / 442700 
lymph node3 / 9161032
mammary gland19 / 153271123
mouth0 / 670520 
muscle12 / 107715111
nerve4 / 15768253
ovary6 / 10205158
pancreas31 / 214812144
parathyroid8 / 20539389
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta50 / 280825178
prostate15 / 18934579
salivary gland0 / 201550 
skin14 / 21057466
spleen2 / 5395237
stomach6 / 9661962
testis23 / 33044269
thymus11 / 81131135
thyroid5 / 47473105
tonsil0 / 169990 
trachea15 / 52413286
umbilical cord0 / 136800 
uterus40 / 232878171
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212195_at
Cell line Expression level Expression bar
721_B_lymphoblasts151.35
Adipocyte897
AdrenalCortex387.25
Adrenalgland163.2
Amygdala990.95
Appendix407.5
AtrioventricularNode165.3
BDCA4+_DentriticCells219.75
Bonemarrow19.45
BronchialEpithelialCells217.3
CD105+_Endothelial239.55
CD14+_Monocytes292.65
CD19+_BCells(neg._sel.)52.25
CD33+_Myeloid626.75
CD34+102.25
CD4+_Tcells1241.6
CD56+_NKCells39.95
CD71+_EarlyErythroid27.9
CD8+_Tcells688.25
CardiacMyocytes2318.5
Caudatenucleus362.5
Cerebellum85.25
CerebellumPeduncles142.4
CiliaryGanglion226.35
CingulateCortex233.3
Colorectaladenocarcinoma302.7
DorsalRootGanglion275.25
FetalThyroid470.7
Fetalbrain118.35
Fetalliver768.1
Fetallung1142.55
GlobusPallidus139.9
Heart36.5
Hypothalamus778.75
Kidney50
Leukemia_chronicMyelogenousK-562157.15
Leukemia_promyelocytic-HL-6016.8
Leukemialymphoblastic(MOLT-4)13.05
Liver56.25
Lung137.65
Lymphnode1048.15
Lymphoma_burkitts(Daudi)14.05
Lymphoma_burkitts(Raji)105.6
MedullaOblongata186
OccipitalLobe470.25
OlfactoryBulb696.25
Ovary425.4
Pancreas185.7
PancreaticIslet829.25
ParietalLobe194.35
Pituitary642.05
Placenta165.15
Pons143.4
PrefrontalCortex1082.25
Prostate413.15
Salivarygland595.8
SkeletalMuscle127.5
Skin128.9
SmoothMuscle2848.55
Spinalcord961.4
SubthalamicNucleus133.75
SuperiorCervicalGanglion106.8
TemporalLobe108.15
Testis29.1
TestisGermCell270.05
TestisIntersitial92.65
TestisLeydigCell129.05
TestisSeminiferousTubule88.35
Thalamus274
Thymus87.25
Thyroid2157.4
Tongue140.05
Tonsil311.35
Trachea353.2
TrigeminalGanglion181.55
Uterus1246.9
UterusCorpus181.25
WholeBlood156.15
Wholebrain179.15
colon559.85
pineal_day606.98
pineal_night593.38
retina851.625
small_intestine332.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15800_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.58 ± 0.23
Basal Forebrain9.87 ± 0.29
Basal Part of Pons9.89 ± 0.16
Cerebellar Cortex9.34 ± 0.2
Cerebellar Nuclei9.94 ± 0.29
Claustrum9.22 ± 0.25
Epithalamus10.06 ± 0.2
Frontal Lobe9.5 ± 0.33
Globus Pallidus10.4 ± 0.13
Hypothalamus9.7 ± 0.24
Insula9.37 ± 0.32
Limbic Lobe9.31 ± 0.33
Mesencephalon9.6 ± 0.32
Myelencephalon9.61 ± 0.32
Occipital Lobe9.85 ± 0.32
Parietal Lobe9.67 ± 0.25
Pontine Tegmentum9.6 ± 0.29
Striatum9.91 ± 0.32
Subthalamus9.85 ± 0.2
Temporal Lobe9.41 ± 0.27
Thalamus9.72 ± 0.21
White Matter10.58 ± 0.22
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IL6RB_HUMAN_888 16 888 903 FETVGMEAATDEGMPK PRIDE
PAp00415855 12 375 386 SHLQNYTVNATK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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