AutismKB 2.0

Annotation Detail for INPP4A


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Basic Information Top
Gene Symbol:INPP4A ( INPP4,TVAS1 )
Gene Full Name: inositol polyphosphate-4-phosphatase, type I, 107kDa
Band: 2q11.2
Quick LinksEntrez ID:3631; OMIM: 600916; Uniprot ID:INP4A_HUMAN; ENSEMBL ID: ENSG00000040933; HGNC ID: 6074
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus30 / 56401253
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal142 / 336030742
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood7 / 12347856
bone2 / 7165527
bone marrow1 / 4880120
brain53 / 110098948
cervix2 / 4817141
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye16 / 21105475
heart3 / 8962633
intestine4 / 23447217
kidney2 / 2117779
larynx0 / 241450 
liver4 / 20774319
lung12 / 33697435
lymph0 / 442700 
lymph node4 / 9161043
mammary gland3 / 15327119
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach2 / 9661920
testis3 / 3304429
thymus2 / 8113124
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204552_at
Cell line Expression level Expression bar
721_B_lymphoblasts42.95
Adipocyte9.2
AdrenalCortex10.45
Adrenalgland8.15
Amygdala71.7
Appendix12.95
AtrioventricularNode7.7
BDCA4+_DentriticCells349.45
Bonemarrow10.05
BronchialEpithelialCells8.55
CD105+_Endothelial9.3
CD14+_Monocytes35.8
CD19+_BCells(neg._sel.)8.6
CD33+_Myeloid20.05
CD34+11.4
CD4+_Tcells218.65
CD56+_NKCells199.2
CD71+_EarlyErythroid8.6
CD8+_Tcells480.55
CardiacMyocytes12.7
Caudatenucleus20.3
Cerebellum24.1
CerebellumPeduncles21.3
CiliaryGanglion6.85
CingulateCortex23.1
Colorectaladenocarcinoma9.05
DorsalRootGanglion7.35
FetalThyroid9.2
Fetalbrain67.65
Fetalliver8.1
Fetallung7.5
GlobusPallidus8
Heart12.45
Hypothalamus16.95
Kidney8.15
Leukemia_chronicMyelogenousK-5628.4
Leukemia_promyelocytic-HL-608.8
Leukemialymphoblastic(MOLT-4)8.95
Liver12.6
Lung10.1
Lymphnode13.65
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)13.5
MedullaOblongata28
OccipitalLobe37.95
OlfactoryBulb7.35
Ovary8.45
Pancreas8.3
PancreaticIslet10.35
ParietalLobe17
Pituitary10.95
Placenta7.55
Pons11.25
PrefrontalCortex62.8
Prostate8.9
Salivarygland8.1
SkeletalMuscle11.7
Skin7.45
SmoothMuscle10.2
Spinalcord12.75
SubthalamicNucleus17.1
SuperiorCervicalGanglion13.95
TemporalLobe9.45
Testis7.85
TestisGermCell7.85
TestisIntersitial7.85
TestisLeydigCell9.85
TestisSeminiferousTubule7.95
Thalamus28.35
Thymus11.25
Thyroid10.3
Tongue10.15
Tonsil9.15
Trachea7.9
TrigeminalGanglion14.15
Uterus7.55
UterusCorpus8.45
WholeBlood20.15
Wholebrain31.1
colon9.4
pineal_day17.52
pineal_night18.6
retina159.45
small_intestine9.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P393531
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.77 ± 0.67
Basal Forebrain6.94 ± 0.61
Basal Part of Pons7.53 ± 0.41
Cerebellar Cortex7.3 ± 0.27
Cerebellar Nuclei6.86 ± 0.74
Claustrum7.01 ± 0.51
Epithalamus7.06 ± 0.53
Frontal Lobe7.25 ± 0.34
Globus Pallidus5.52 ± 0.46
Hypothalamus7.27 ± 0.21
Insula7.47 ± 0.54
Limbic Lobe7.1 ± 0.66
Mesencephalon6.78 ± 0.51
Myelencephalon6.95 ± 0.61
Occipital Lobe6.49 ± 0.73
Parietal Lobe7.04 ± 0.44
Pontine Tegmentum6.98 ± 0.57
Striatum6.73 ± 0.51
Subthalamus7.13 ± 1.03
Temporal Lobe7.24 ± 0.33
Thalamus6.88 ± 0.44
White Matter5.15 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Inpp4aCBCerebellum19.81
86.38
Inpp4aCTXCerebral cortex44.59
33.48
Inpp4aHIPHippocampal region23.31
24.16
Inpp4aHPFHippocampal formation28.64
26.29
Inpp4aHYHypothalamus10.07
7.47
Inpp4aLSXLateral septal complex11.3
8.66
Inpp4aMBMidbrain13.32
12.75
Inpp4aMYMedulla19.78
23.01
Inpp4aOLFOlfactory bulb21.25
17.19
Inpp4aPPons15.3
17.09
Inpp4aPALPallidum12.41
12.88
Inpp4aRHPRetrohippocampal region38.77
29.95
Inpp4asAMYStriatum-like amygdalar nuclei12.2
9.54
Inpp4aSTRStriatum19.43
14.66
Inpp4aSTRdStriatum dorsal region24.38
18.8
Inpp4aSTRvStriatum ventral region12.4
8.35
Inpp4aTHThalamus37.98
31.63
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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