AutismKB 2.0

Annotation Detail for INSR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:INSR ( CD220,HHF5 )
Gene Full Name: insulin receptor
Band: 19p13.2
Quick LinksEntrez ID:3643; OMIM: 147670; Uniprot ID:INSR_HUMAN; ENSEMBL ID: ENSG00000171105; HGNC ID: 6091
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus39 / 56401269
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult156 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal189 / 336030756
ovarian tumor8 / 76682104
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites1 / 4001524
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain22 / 110098919
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye16 / 21105475
heart3 / 8962633
intestine19 / 23447281
kidney18 / 21177784
larynx0 / 241450 
liver9 / 20774343
lung46 / 336974136
lymph0 / 442700 
lymph node4 / 9161043
mammary gland13 / 15327184
mouth1 / 6705214
muscle8 / 10771574
nerve1 / 1576863
ovary15 / 102051146
pancreas11 / 21481251
parathyroid4 / 20539194
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta37 / 280825131
prostate7 / 18934536
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach2 / 9661920
testis7 / 33044221
thymus1 / 8113112
thyroid6 / 47473126
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213792_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts137.45
Adipocyte57.7
AdrenalCortex1274.9
Adrenalgland133.75
Amygdala9.4
Appendix28
AtrioventricularNode24.3
BDCA4+_DentriticCells37.3
Bonemarrow27.4
BronchialEpithelialCells18.65
CD105+_Endothelial124.65
CD14+_Monocytes50.1
CD19+_BCells(neg._sel.)9.3
CD33+_Myeloid112.95
CD34+126
CD4+_Tcells13.85
CD56+_NKCells17.05
CD71+_EarlyErythroid48.15
CD8+_Tcells8.65
CardiacMyocytes22.65
Caudatenucleus10.45
Cerebellum55.2
CerebellumPeduncles113.75
CiliaryGanglion19.4
CingulateCortex54.3
Colorectaladenocarcinoma9.05
DorsalRootGanglion17.75
FetalThyroid191.25
Fetalbrain48.9
Fetalliver64.4
Fetallung24.25
GlobusPallidus40.05
Heart11.7
Hypothalamus30.9
Kidney171.3
Leukemia_chronicMyelogenousK-56215.65
Leukemia_promyelocytic-HL-609.7
Leukemialymphoblastic(MOLT-4)14.7
Liver36.7
Lung29.75
Lymphnode23.2
Lymphoma_burkitts(Daudi)25.85
Lymphoma_burkitts(Raji)17.05
MedullaOblongata32.85
OccipitalLobe40.5
OlfactoryBulb72.45
Ovary1078.05
Pancreas682.15
PancreaticIslet658.15
ParietalLobe57.05
Pituitary68.85
Placenta1216.95
Pons35.25
PrefrontalCortex55.35
Prostate79.8
Salivarygland35.6
SkeletalMuscle32.7
Skin22.65
SmoothMuscle33.05
Spinalcord30
SubthalamicNucleus24.9
SuperiorCervicalGanglion31.8
TemporalLobe32.05
Testis22.55
TestisGermCell29.9
TestisIntersitial22.85
TestisLeydigCell27.95
TestisSeminiferousTubule85.75
Thalamus28.45
Thymus21.45
Thyroid22.2
Tongue27.2
Tonsil25.85
Trachea102.3
TrigeminalGanglion20.7
Uterus63.15
UterusCorpus150.75
WholeBlood10.7
Wholebrain9.45
colon21.75
pineal_day30.24
pineal_night30.74
retina65.975
small_intestine21.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_354_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.74 ± 1.06
Basal Forebrain2.22 ± 0.21
Basal Part of Pons2.06 ± 0.4
Cerebellar Cortex2.95 ± 0.47
Cerebellar Nuclei2.71 ± 0.67
Claustrum3.11 ± 0.66
Epithalamus2.13 ± 0.69
Frontal Lobe2.3 ± 0.64
Globus Pallidus2.4 ± 0.5
Hypothalamus2.39 ± 0.65
Insula2.39 ± 0.93
Limbic Lobe2.35 ± 0.76
Mesencephalon2.6 ± 0.74
Myelencephalon2.46 ± 0.69
Occipital Lobe2.39 ± 0.74
Parietal Lobe2.48 ± 0.76
Pontine Tegmentum2.51 ± 0.72
Striatum2.06 ± 0.64
Subthalamus3.01 ± 1.48
Temporal Lobe2.38 ± 0.69
Thalamus2.41 ± 0.61
White Matter3.27 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
InsrCBCerebellum9.35
9.2
InsrCTXCerebral cortex11.2
7.46
InsrHIPHippocampal region11.01
9.71
InsrHPFHippocampal formation9.38
7.57
InsrHYHypothalamus1.17
0.81
InsrLSXLateral septal complex0.59
0.33
InsrMBMidbrain3.15
2.86
InsrMYMedulla12.16
12.13
InsrOLFOlfactory bulb6.44
4.9
InsrPPons4.64
5.04
InsrPALPallidum3.3
2.72
InsrRHPRetrohippocampal region6.79
4.72
InsrsAMYStriatum-like amygdalar nuclei1.51
0.92
InsrSTRStriatum2.99
2.18
InsrSTRdStriatum dorsal region3.35
2.6
InsrSTRvStriatum ventral region2.77
1.61
InsrTHThalamus3.88
3.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042362 13 298 310 RQGCHQYVIHNNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved