AutismKB 2.0

Annotation Detail for ITGA6


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Basic Information Top
Gene Symbol:ITGA6 ( CD49f,DKFZp686J01244,FLJ18737,ITGA6B,VLA-6 )
Gene Full Name: integrin, alpha 6
Band: 2q31.1
Quick LinksEntrez ID:3655; OMIM: 147556; Uniprot ID:ITA6_HUMAN; ENSEMBL ID: ENSG00000091409; HGNC ID: 6142
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst8 / 62319128
fetus20 / 56401235
neonate3 / 3109796
infant0 / 236200 
juvenile7 / 55556125
adult171 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor32 / 114246280
esophageal tumor5 / 17290289
gastrointestinal tumor18 / 119369150
germ cell tumor11 / 26384541
glioma2 / 10688318
head and neck tumor17 / 136302124
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor6 / 9635962
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal202 / 336030760
ovarian tumor5 / 7668265
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor13 / 124949104
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites5 / 40015124
bladder8 / 29757268
blood1 / 1234788
bone4 / 7165555
bone marrow2 / 4880140
brain34 / 110098930
cervix1 / 4817120
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue14 / 21572264
esophagus5 / 20209247
eye8 / 21105437
heart5 / 8962655
intestine44 / 234472187
kidney11 / 21177751
larynx1 / 2414541
liver9 / 20774343
lung14 / 33697441
lymph1 / 4427022
lymph node0 / 916100 
mammary gland22 / 153271143
mouth6 / 6705289
muscle7 / 10771564
nerve1 / 1576863
ovary6 / 10205158
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta36 / 280825128
prostate13 / 18934568
salivary gland0 / 201550 
skin16 / 21057475
spleen3 / 5395255
stomach17 / 96619175
testis33 / 33044299
thymus1 / 8113112
thyroid6 / 47473126
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord3 / 13680219
uterus12 / 23287851
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215177_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.5
Adipocyte9.45
AdrenalCortex10.05
Adrenalgland6.8
Amygdala7.9
Appendix12.35
AtrioventricularNode10
BDCA4+_DentriticCells7.2
Bonemarrow8.35
BronchialEpithelialCells807
CD105+_Endothelial7.45
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)7.95
CD33+_Myeloid8.8
CD34+10.5
CD4+_Tcells336
CD56+_NKCells18.4
CD71+_EarlyErythroid7.3
CD8+_Tcells255.1
CardiacMyocytes17.85
Caudatenucleus7.95
Cerebellum6.85
CerebellumPeduncles9.8
CiliaryGanglion8.05
CingulateCortex9.1
Colorectaladenocarcinoma194.2
DorsalRootGanglion14.05
FetalThyroid7.9
Fetalbrain11.55
Fetalliver10.65
Fetallung17.35
GlobusPallidus7.2
Heart11.1
Hypothalamus8.9
Kidney8.95
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-608
Leukemialymphoblastic(MOLT-4)5.9
Liver13.9
Lung8.9
Lymphnode39.25
Lymphoma_burkitts(Daudi)10.25
Lymphoma_burkitts(Raji)13.85
MedullaOblongata8.05
OccipitalLobe10.55
OlfactoryBulb115.15
Ovary7
Pancreas47.65
PancreaticIslet9.65
ParietalLobe10.25
Pituitary9.55
Placenta57.2
Pons8.9
PrefrontalCortex11.85
Prostate9.4
Salivarygland30.25
SkeletalMuscle10.2
Skin7.6
SmoothMuscle8.1
Spinalcord12.4
SubthalamicNucleus7.3
SuperiorCervicalGanglion10.7
TemporalLobe7.65
Testis6.9
TestisGermCell58.1
TestisIntersitial8.35
TestisLeydigCell9.65
TestisSeminiferousTubule8.4
Thalamus8.65
Thymus6.75
Thyroid8.45
Tongue9.95
Tonsil8.65
Trachea45.3
TrigeminalGanglion9.45
Uterus25.1
UterusCorpus7.7
WholeBlood9.55
Wholebrain6.2
colon188.3
pineal_day9.94
pineal_night10.04
retina29.45
small_intestine144.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12063_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.28 ± 0.33
Basal Forebrain7.44 ± 0.24
Basal Part of Pons6.55 ± 0.35
Cerebellar Cortex6.73 ± 0.28
Cerebellar Nuclei7.1 ± 0.42
Claustrum6.65 ± 0.5
Epithalamus8.14 ± 0.25
Frontal Lobe7.3 ± 0.44
Globus Pallidus8.39 ± 0.33
Hypothalamus7.41 ± 0.57
Insula7.26 ± 0.11
Limbic Lobe7.21 ± 0.59
Mesencephalon7.45 ± 0.4
Myelencephalon7.39 ± 0.49
Occipital Lobe7.54 ± 0.54
Parietal Lobe7.25 ± 0.42
Pontine Tegmentum7.48 ± 0.44
Striatum7.93 ± 0.39
Subthalamus7.23 ± 0.26
Temporal Lobe7.17 ± 0.34
Thalamus7.7 ± 0.34
White Matter7.51 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itga6CBCerebellum15.9
17.15
Itga6CTXCerebral cortex2.85
1.77
Itga6HIPHippocampal region4.36
3.59
Itga6HPFHippocampal formation5.14
4.01
Itga6HYHypothalamus4.56
3.25
Itga6LSXLateral septal complex0.79
0.84
Itga6MBMidbrain2.57
2.41
Itga6MYMedulla7
7.65
Itga6OLFOlfactory bulb21.58
16.44
Itga6PPons4.39
4.81
Itga6PALPallidum2.96
2.37
Itga6RHPRetrohippocampal region6.52
4.67
Itga6sAMYStriatum-like amygdalar nuclei2.31
1.67
Itga6STRStriatum1.51
1.06
Itga6STRdStriatum dorsal region0.62
0.38
Itga6STRvStriatum ventral region4.62
2.93
Itga6THThalamus2.72
2
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITA6_HUMAN_1006 9 1006 1014 LNYLDILMR PRIDE
ITA6_HUMAN_1015 13 1015 1027 AFIDVTAAAENIR PRIDE
ITA6_HUMAN_738 15 738 752 LIATFPDTLTYSAYR PRIDE
PAp00002421 14 185 198 FGSCQQGVAATFTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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