AutismKB 2.0

Annotation Detail for IREB2


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Basic Information Top
Gene Symbol:IREB2 ( ACO3,FLJ23381,IRP2,IRP2AD )
Gene Full Name: iron-responsive element binding protein 2
Band: 15q25.1
Quick LinksEntrez ID:3658; OMIM: 147582; Uniprot ID:IREB2_HUMAN; ENSEMBL ID: ENSG00000136381; HGNC ID: 6115
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst9 / 62319144
fetus54 / 56401295
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult99 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor42 / 263845159
glioma1 / 1068839
head and neck tumor15 / 136302110
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal179 / 336030753
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites1 / 4001524
bladder5 / 29757168
blood5 / 12347840
bone3 / 7165541
bone marrow5 / 48801102
brain44 / 110098939
cervix3 / 4817162
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue21 / 21572297
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine12 / 23447251
kidney11 / 21177751
larynx2 / 2414582
liver8 / 20774338
lung12 / 33697435
lymph0 / 442700 
lymph node7 / 9161076
mammary gland4 / 15327126
mouth9 / 67052134
muscle4 / 10771537
nerve0 / 157680 
ovary2 / 10205119
pancreas12 / 21481255
parathyroid1 / 2053948
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta17 / 28082560
prostate2 / 18934510
salivary gland0 / 201550 
skin9 / 21057442
spleen5 / 5395292
stomach2 / 9661920
testis43 / 330442130
thymus12 / 81131147
thyroid3 / 4747363
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214666_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.45
Adipocyte11.5
AdrenalCortex17.05
Adrenalgland10.15
Amygdala11.75
Appendix17.7
AtrioventricularNode23
BDCA4+_DentriticCells12.6
Bonemarrow13.4
BronchialEpithelialCells11.25
CD105+_Endothelial12.2
CD14+_Monocytes24.85
CD19+_BCells(neg._sel.)12.45
CD33+_Myeloid14.8
CD34+13.95
CD4+_Tcells12.6
CD56+_NKCells13.75
CD71+_EarlyErythroid11.4
CD8+_Tcells12.6
CardiacMyocytes20.5
Caudatenucleus9.7
Cerebellum9.35
CerebellumPeduncles16.3
CiliaryGanglion22.6
CingulateCortex12.15
Colorectaladenocarcinoma11.65
DorsalRootGanglion15.6
FetalThyroid12.4
Fetalbrain11.4
Fetalliver9.85
Fetallung9.5
GlobusPallidus10
Heart18.2
Hypothalamus12.1
Kidney10.35
Leukemia_chronicMyelogenousK-56210.2
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)9.3
Liver21.6
Lung12.35
Lymphnode9.3
Lymphoma_burkitts(Daudi)15
Lymphoma_burkitts(Raji)18.7
MedullaOblongata9.15
OccipitalLobe10.45
OlfactoryBulb9.1
Ovary12.35
Pancreas11.45
PancreaticIslet12.45
ParietalLobe13.1
Pituitary13.6
Placenta11.2
Pons11.3
PrefrontalCortex13.45
Prostate12.05
Salivarygland11.1
SkeletalMuscle25.6
Skin20.35
SmoothMuscle13.6
Spinalcord12.05
SubthalamicNucleus13.05
SuperiorCervicalGanglion29.5
TemporalLobe10.85
Testis9.45
TestisGermCell9.25
TestisIntersitial12.7
TestisLeydigCell14
TestisSeminiferousTubule10
Thalamus12.15
Thymus8.65
Thyroid12.45
Tongue20.95
Tonsil11.35
Trachea9.55
TrigeminalGanglion25.55
Uterus8.55
UterusCorpus13.05
WholeBlood12.8
Wholebrain8.5
colon11.75
pineal_day13.82
pineal_night14.74
retina13.9
small_intestine11.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P421898
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 1.02
Basal Forebrain1.57 ± 0.23
Basal Part of Pons1.28 ± 0.33
Cerebellar Cortex1.71 ± 0.78
Cerebellar Nuclei1.9 ± 0.74
Claustrum2.58 ± 0.85
Epithalamus1.3 ± 0.69
Frontal Lobe1.45 ± 0.65
Globus Pallidus2.07 ± 0.4
Hypothalamus1.72 ± 0.63
Insula1.65 ± 0.86
Limbic Lobe1.6 ± 0.62
Mesencephalon1.8 ± 0.58
Myelencephalon1.65 ± 0.69
Occipital Lobe1.82 ± 0.76
Parietal Lobe1.65 ± 0.68
Pontine Tegmentum1.64 ± 0.67
Striatum1.67 ± 0.49
Subthalamus1.75 ± 0.59
Temporal Lobe1.45 ± 0.56
Thalamus1.57 ± 0.57
White Matter2.05 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ireb2CBCerebellum0
0
Ireb2CTXCerebral cortex0
0
Ireb2HIPHippocampal region0
0
Ireb2HPFHippocampal formation0
0
Ireb2HYHypothalamus0
0
Ireb2LSXLateral septal complex0
0
Ireb2MBMidbrain0
0
Ireb2MYMedulla0
0
Ireb2OLFOlfactory bulb0
0
Ireb2PPons0
0
Ireb2PALPallidum0
0
Ireb2RHPRetrohippocampal region0
0
Ireb2sAMYStriatum-like amygdalar nuclei0
0
Ireb2STRStriatum0
0
Ireb2STRdStriatum dorsal region0
0
Ireb2STRvStriatum ventral region0
0
Ireb2THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005969 31 186 216 NSGTFSSQIENTPILCPFHLQPVPEPETVLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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