AutismKB 2.0

Annotation Detail for IRF2


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Basic Information Top
Gene Symbol:IRF2 ( DKFZp686F0244,IRF-2 )
Gene Full Name: interferon regulatory factor 2
Band: 4q35.1
Quick LinksEntrez ID:3660; OMIM: 147576; Uniprot ID:IRF2_HUMAN; ENSEMBL ID: ENSG00000168310; HGNC ID: 6117
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult140 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor42 / 114246367
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor22 / 136302161
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia2 / 9725020
normal134 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood24 / 123478194
bone3 / 7165541
bone marrow9 / 48801184
brain33 / 110098929
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye14 / 21105466
heart2 / 8962622
intestine49 / 234472208
kidney5 / 21177723
larynx1 / 2414541
liver2 / 2077439
lung7 / 33697420
lymph1 / 4427022
lymph node8 / 9161087
mammary gland4 / 15327126
mouth19 / 67052283
muscle2 / 10771518
nerve1 / 1576863
ovary2 / 10205119
pancreas3 / 21481213
parathyroid3 / 20539146
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta13 / 28082546
prostate7 / 18934536
salivary gland1 / 2015549
skin5 / 21057423
spleen2 / 5395237
stomach4 / 9661941
testis4 / 33044212
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus12 / 23287851
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203275_at
Cell line Expression level Expression bar
721_B_lymphoblasts103.35
Adipocyte6.55
AdrenalCortex7.7
Adrenalgland31.45
Amygdala7.15
Appendix6.6
AtrioventricularNode4.4
BDCA4+_DentriticCells23.3
Bonemarrow33.8
BronchialEpithelialCells6.5
CD105+_Endothelial14.05
CD14+_Monocytes69.15
CD19+_BCells(neg._sel.)50.1
CD33+_Myeloid40.95
CD34+9.95
CD4+_Tcells31.3
CD56+_NKCells56.95
CD71+_EarlyErythroid33.8
CD8+_Tcells42.9
CardiacMyocytes6.95
Caudatenucleus5.4
Cerebellum7.85
CerebellumPeduncles6.8
CiliaryGanglion4.45
CingulateCortex6.2
Colorectaladenocarcinoma5.85
DorsalRootGanglion4.85
FetalThyroid5.45
Fetalbrain5.25
Fetalliver14.55
Fetallung18
GlobusPallidus4.5
Heart8.15
Hypothalamus6.45
Kidney5.15
Leukemia_chronicMyelogenousK-5624.85
Leukemia_promyelocytic-HL-6021.6
Leukemialymphoblastic(MOLT-4)12.15
Liver8.4
Lung11.15
Lymphnode33.9
Lymphoma_burkitts(Daudi)7.95
Lymphoma_burkitts(Raji)15.7
MedullaOblongata4.9
OccipitalLobe5.8
OlfactoryBulb4.8
Ovary4.15
Pancreas4.65
PancreaticIslet6.6
ParietalLobe6.3
Pituitary6.6
Placenta12.55
Pons5.15
PrefrontalCortex8.7
Prostate7.95
Salivarygland5.75
SkeletalMuscle6.75
Skin4.55
SmoothMuscle6.9
Spinalcord14.35
SubthalamicNucleus6.05
SuperiorCervicalGanglion6.65
TemporalLobe5.25
Testis4.75
TestisGermCell4.65
TestisIntersitial4.55
TestisLeydigCell6.1
TestisSeminiferousTubule4.75
Thalamus5.9
Thymus23.35
Thyroid11.6
Tongue6.3
Tonsil13.8
Trachea13.45
TrigeminalGanglion6.75
Uterus6.5
UterusCorpus5.9
WholeBlood439.5
Wholebrain5.85
colon16
pineal_day23.84
pineal_night34.16
retina33.275
small_intestine11.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P125082
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 1.06
Basal Forebrain1.51 ± 0.21
Basal Part of Pons1.27 ± 0.31
Cerebellar Cortex1.59 ± 0.75
Cerebellar Nuclei2.09 ± 0.86
Claustrum2.49 ± 0.75
Epithalamus1.37 ± 0.69
Frontal Lobe1.52 ± 0.75
Globus Pallidus2.23 ± 0.72
Hypothalamus1.58 ± 0.68
Insula1.42 ± 0.54
Limbic Lobe1.6 ± 0.63
Mesencephalon1.76 ± 0.61
Myelencephalon1.63 ± 0.66
Occipital Lobe1.62 ± 0.48
Parietal Lobe1.61 ± 0.57
Pontine Tegmentum1.76 ± 0.75
Striatum1.75 ± 0.55
Subthalamus1.76 ± 0.64
Temporal Lobe1.46 ± 0.59
Thalamus1.58 ± 0.55
White Matter2.5 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Irf2CBCerebellum2.64
3.74
Irf2CTXCerebral cortex19.12
13.82
Irf2HIPHippocampal region9.63
10.14
Irf2HPFHippocampal formation7.08
7.25
Irf2HYHypothalamus1.04
0.87
Irf2LSXLateral septal complex0.46
0.37
Irf2MBMidbrain2.15
4.16
Irf2MYMedulla3.34
4.19
Irf2OLFOlfactory bulb8.68
7.38
Irf2PPons2.28
2.82
Irf2PALPallidum1.71
1.27
Irf2RHPRetrohippocampal region2.53
2.79
Irf2sAMYStriatum-like amygdalar nuclei0.71
0.43
Irf2STRStriatum1.1
1.05
Irf2STRdStriatum dorsal region1.13
1.21
Irf2STRvStriatum ventral region1.36
1.02
Irf2THThalamus8.02
9.25
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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