AutismKB 2.0

Annotation Detail for IRF5


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Basic Information Top
Gene Symbol:IRF5 ( SLEB10 )
Gene Full Name: interferon regulatory factor 5
Band: 7q32.1
Quick LinksEntrez ID:3663; OMIM: 607218; Uniprot ID:IRF5_HUMAN; ENSEMBL ID: ENSG00000128604; HGNC ID: 6120
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate7 / 31097225
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor1 / 1363027
kidney tumor6 / 6895987
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal79 / 336030723
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood14 / 123478113
bone1 / 7165513
bone marrow1 / 4880120
brain22 / 110098919
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine5 / 23447221
kidney13 / 21177761
larynx0 / 241450 
liver0 / 2077430 
lung7 / 33697420
lymph0 / 442700 
lymph node14 / 91610152
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach1 / 9661910
testis1 / 3304423
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205468_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.1
Adipocyte6.2
AdrenalCortex7.15
Adrenalgland5.35
Amygdala6.5
Appendix6.85
AtrioventricularNode4.95
BDCA4+_DentriticCells7.15
Bonemarrow6.45
BronchialEpithelialCells6.2
CD105+_Endothelial6.2
CD14+_Monocytes6.7
CD19+_BCells(neg._sel.)6.5
CD33+_Myeloid17
CD34+7.6
CD4+_Tcells6.7
CD56+_NKCells7.4
CD71+_EarlyErythroid5.8
CD8+_Tcells5.45
CardiacMyocytes9
Caudatenucleus5.6
Cerebellum5
CerebellumPeduncles7.1
CiliaryGanglion4.6
CingulateCortex6.4
Colorectaladenocarcinoma15.25
DorsalRootGanglion4.85
FetalThyroid6.05
Fetalbrain6.05
Fetalliver5.45
Fetallung4.95
GlobusPallidus4.55
Heart10.9
Hypothalamus6.5
Kidney5.35
Leukemia_chronicMyelogenousK-5625.5
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)5
Liver9
Lung7.5
Lymphnode5.4
Lymphoma_burkitts(Daudi)7.95
Lymphoma_burkitts(Raji)9.2
MedullaOblongata5.6
OccipitalLobe5.5
OlfactoryBulb4.75
Ovary4.1
Pancreas5
PancreaticIslet6.6
ParietalLobe6.7
Pituitary12.15
Placenta6.15
Pons6
PrefrontalCortex7.4
Prostate7.15
Salivarygland5.05
SkeletalMuscle11.65
Skin5.1
SmoothMuscle7.05
Spinalcord6.55
SubthalamicNucleus5.65
SuperiorCervicalGanglion7.7
TemporalLobe5.75
Testis5.25
TestisGermCell4.95
TestisIntersitial5.15
TestisLeydigCell6.2
TestisSeminiferousTubule5.2
Thalamus6.2
Thymus4.8
Thyroid7.7
Tongue6.3
Tonsil6.05
Trachea5.2
TrigeminalGanglion6.65
Uterus5.15
UterusCorpus6.5
WholeBlood6.7
Wholebrain5.05
colon6.25
pineal_day7.4
pineal_night7.26
retina7.425
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P500271
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.22 ± 0.59
Basal Forebrain5.32 ± 0.43
Basal Part of Pons5.07 ± 0.31
Cerebellar Cortex4.81 ± 0.42
Cerebellar Nuclei6.17 ± 0.5
Claustrum5.62 ± 0.85
Epithalamus4.82 ± 0.47
Frontal Lobe5.33 ± 0.63
Globus Pallidus6.21 ± 0.26
Hypothalamus4.87 ± 0.64
Insula4.91 ± 0.64
Limbic Lobe5.36 ± 0.73
Mesencephalon5.64 ± 0.57
Myelencephalon5.46 ± 0.71
Occipital Lobe5.26 ± 0.78
Parietal Lobe5.31 ± 0.6
Pontine Tegmentum5.43 ± 0.7
Striatum5.99 ± 0.58
Subthalamus5.65 ± 0.3
Temporal Lobe5.26 ± 0.66
Thalamus5.73 ± 0.58
White Matter5.26 ± 0.35
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IRF5_HUMAN_99 10 99 108 DFRLIYDGPR PRIDE
PAp00011860 20 344 363 VFWSGPCASAHDSCPNPIQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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