AutismKB 2.0

Annotation Detail for ISG20


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Basic Information Top
Gene Symbol:ISG20 ( CD25,HEM45 )
Gene Full Name: interferon stimulated exonuclease gene 20kDa
Band: 15q26.1
Quick LinksEntrez ID:3669; OMIM: 604533; Uniprot ID:ISG20_HUMAN; ENSEMBL ID: ENSG00000172183; HGNC ID: 6130
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal65 / 336030719
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone1 / 7165513
bone marrow2 / 4880140
brain7 / 11009896
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye6 / 21105428
heart1 / 8962611
intestine12 / 23447251
kidney6 / 21177728
larynx0 / 241450 
liver11 / 20774352
lung11 / 33697432
lymph0 / 442700 
lymph node11 / 91610120
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate6 / 18934531
salivary gland0 / 201550 
skin8 / 21057437
spleen2 / 5395237
stomach2 / 9661920
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil11 / 16999647
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 33304_at
Cell line Expression level Expression bar
721_B_lymphoblasts176.2
Adipocyte5
AdrenalCortex5.4
Adrenalgland4.4
Amygdala5.25
Appendix5.1
AtrioventricularNode3.9
BDCA4+_DentriticCells494.05
Bonemarrow58
BronchialEpithelialCells7.15
CD105+_Endothelial16.7
CD14+_Monocytes26.45
CD19+_BCells(neg._sel.)1039.7
CD33+_Myeloid6.6
CD34+8.55
CD4+_Tcells373.45
CD56+_NKCells314.15
CD71+_EarlyErythroid733.2
CD8+_Tcells387.45
CardiacMyocytes6.5
Caudatenucleus4.65
Cerebellum4.2
CerebellumPeduncles5.85
CiliaryGanglion3.55
CingulateCortex4.95
Colorectaladenocarcinoma5.3
DorsalRootGanglion3.75
FetalThyroid5.2
Fetalbrain4.85
Fetalliver5.3
Fetallung10.2
GlobusPallidus3.75
Heart37.1
Hypothalamus5.6
Kidney4.15
Leukemia_chronicMyelogenousK-5624.7
Leukemia_promyelocytic-HL-6041.65
Leukemialymphoblastic(MOLT-4)4.15
Liver7.25
Lung106.35
Lymphnode48.35
Lymphoma_burkitts(Daudi)639.4
Lymphoma_burkitts(Raji)116.15
MedullaOblongata4.55
OccipitalLobe4.4
OlfactoryBulb4.25
Ovary3.35
Pancreas10.15
PancreaticIslet6.9
ParietalLobe5.45
Pituitary6.05
Placenta6.25
Pons4.8
PrefrontalCortex6.45
Prostate22.7
Salivarygland8.2
SkeletalMuscle5.9
Skin3.8
SmoothMuscle5.95
Spinalcord5.45
SubthalamicNucleus4.55
SuperiorCervicalGanglion5.65
TemporalLobe4.6
Testis4.45
TestisGermCell4.25
TestisIntersitial4.2
TestisLeydigCell4.9
TestisSeminiferousTubule4.25
Thalamus4.9
Thymus65.65
Thyroid15.65
Tongue5
Tonsil56.2
Trachea17.45
TrigeminalGanglion4.95
Uterus4.25
UterusCorpus4.7
WholeBlood259.25
Wholebrain4.3
colon13.2
pineal_day6.12
pineal_night6.06
retina6.275
small_intestine20.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8892_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.86 ± 0.7
Basal Forebrain4.81 ± 0.52
Basal Part of Pons4.1 ± 0.82
Cerebellar Cortex3.99 ± 0.37
Cerebellar Nuclei4.78 ± 0.45
Claustrum3.78 ± 0.71
Epithalamus4.56 ± 0.71
Frontal Lobe4.45 ± 0.75
Globus Pallidus5.95 ± 0.3
Hypothalamus4.94 ± 0.54
Insula4.33 ± 0.5
Limbic Lobe4.1 ± 0.82
Mesencephalon4.67 ± 0.72
Myelencephalon4.61 ± 0.72
Occipital Lobe4.45 ± 0.85
Parietal Lobe4.29 ± 0.64
Pontine Tegmentum4.57 ± 0.66
Striatum5.45 ± 0.48
Subthalamus5.55 ± 0.36
Temporal Lobe4.41 ± 0.62
Thalamus4.66 ± 0.6
White Matter6.24 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Isg20CBCerebellum2.17
4.08
Isg20CTXCerebral cortex4.19
3.8
Isg20HIPHippocampal region2.59
3.29
Isg20HPFHippocampal formation2.3
2.86
Isg20HYHypothalamus1.61
1.63
Isg20LSXLateral septal complex0.93
0.68
Isg20MBMidbrain1.75
2.03
Isg20MYMedulla3.58
4.48
Isg20OLFOlfactory bulb2.1
1.58
Isg20PPons2.64
3.11
Isg20PALPallidum1.21
1.37
Isg20RHPRetrohippocampal region1.55
1.74
Isg20sAMYStriatum-like amygdalar nuclei0.22
0.12
Isg20STRStriatum0.92
0.97
Isg20STRdStriatum dorsal region0.6
0.64
Isg20STRvStriatum ventral region2.16
2.31
Isg20THThalamus3.91
3.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ISG20_HUMAN_156 11 156 166 ATMELYQISQR PRIDE
ISG20_HUMAN_41 12 41 52 FIRPEGEITDYR PRIDE
ISG20_HUMAN_55 19 55 73 VSGVTPQHMVGATPFAVAR PRIDE
ISG20_HUMAN_74 8 74 81 LEILQLLK PRIDE
PAp00001367 14 28 41 CSLVNVHGAVLYDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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