AutismKB 2.0

Annotation Detail for ITGA2


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Basic Information Top
Gene Symbol:ITGA2 ( BR,CD49B,GPIa,VLA-2,VLAA2 )
Gene Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Band: 5q11.2
Quick LinksEntrez ID:3673; OMIM: 192974; Uniprot ID:ITA2_HUMAN; ENSEMBL ID: ENSG00000164171; HGNC ID: 6137
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor4 / 26384515
glioma11 / 106883102
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal97 / 336030728
ovarian tumor0 / 766820 
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites5 / 40015124
bladder4 / 29757134
blood2 / 12347816
bone2 / 7165527
bone marrow5 / 48801102
brain29 / 110098926
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine9 / 23447238
kidney16 / 21177775
larynx1 / 2414541
liver0 / 2077430 
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland1 / 2015549
skin4 / 21057418
spleen1 / 5395218
stomach7 / 9661972
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus2 / 2328788
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205032_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte7.85
AdrenalCortex10.2
Adrenalgland7.15
Amygdala8.35
Appendix11.05
AtrioventricularNode7.75
BDCA4+_DentriticCells7.45
Bonemarrow7.95
BronchialEpithelialCells41.15
CD105+_Endothelial7.95
CD14+_Monocytes8.35
CD19+_BCells(neg._sel.)8.1
CD33+_Myeloid9.6
CD34+9.7
CD4+_Tcells8.3
CD56+_NKCells8.8
CD71+_EarlyErythroid7.45
CD8+_Tcells7.1
CardiacMyocytes16.6
Caudatenucleus7.55
Cerebellum6.7
CerebellumPeduncles9.4
CiliaryGanglion5.75
CingulateCortex8.6
Colorectaladenocarcinoma8.1
DorsalRootGanglion6.5
FetalThyroid8.3
Fetalbrain7.9
Fetalliver6.9
Fetallung6.65
GlobusPallidus6.25
Heart11.25
Hypothalamus9.3
Kidney7.15
Leukemia_chronicMyelogenousK-5627.2
Leukemia_promyelocytic-HL-607.05
Leukemialymphoblastic(MOLT-4)6.3
Liver11.4
Lung8.75
Lymphnode6.9
Lymphoma_burkitts(Daudi)10.3
Lymphoma_burkitts(Raji)11.25
MedullaOblongata7.6
OccipitalLobe7.65
OlfactoryBulb6.25
Ovary5.75
Pancreas6.9
PancreaticIslet8.55
ParietalLobe9.45
Pituitary10.3
Placenta8.05
Pons7.95
PrefrontalCortex9.9
Prostate9.2
Salivarygland8.25
SkeletalMuscle10.45
Skin7.25
SmoothMuscle9.1
Spinalcord8.55
SubthalamicNucleus7.5
SuperiorCervicalGanglion10.25
TemporalLobe8.75
Testis6.85
TestisGermCell6.65
TestisIntersitial6.7
TestisLeydigCell8.8
TestisSeminiferousTubule6.85
Thalamus8.2
Thymus6.25
Thyroid9.9
Tongue9.45
Tonsil7.9
Trachea6.85
TrigeminalGanglion8.7
Uterus6.35
UterusCorpus7.25
WholeBlood8.6
Wholebrain6.6
colon8.1
pineal_day9.78
pineal_night9.56
retina10
small_intestine7.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P178800
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 1.16
Basal Forebrain1.55 ± 0.42
Basal Part of Pons1.67 ± 0.64
Cerebellar Cortex1.23 ± 0.54
Cerebellar Nuclei1.94 ± 0.75
Claustrum2.3 ± 0.7
Epithalamus2.78 ± 0.53
Frontal Lobe1.48 ± 0.9
Globus Pallidus2.7 ± 0.65
Hypothalamus1.45 ± 0.81
Insula1.26 ± 0.55
Limbic Lobe1.56 ± 0.85
Mesencephalon1.61 ± 0.76
Myelencephalon1.6 ± 0.74
Occipital Lobe1.58 ± 0.81
Parietal Lobe1.64 ± 0.78
Pontine Tegmentum1.69 ± 0.74
Striatum1.79 ± 0.7
Subthalamus1.46 ± 0.55
Temporal Lobe1.41 ± 0.71
Thalamus1.59 ± 0.74
White Matter3.78 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itga2CBCerebellum4.7
6.97
Itga2CTXCerebral cortex1.31
1.13
Itga2HIPHippocampal region0.69
0.92
Itga2HPFHippocampal formation0.5
0.61
Itga2HYHypothalamus0.61
0.65
Itga2LSXLateral septal complex1.24
1.06
Itga2MBMidbrain1.91
2.27
Itga2MYMedulla3.85
4.47
Itga2OLFOlfactory bulb2.8
2.24
Itga2PPons1.92
2.51
Itga2PALPallidum1.9
1.85
Itga2RHPRetrohippocampal region0.22
0.25
Itga2sAMYStriatum-like amygdalar nuclei0.42
0.47
Itga2STRStriatum1.11
1.11
Itga2STRdStriatum dorsal region0.53
0.77
Itga2STRvStriatum ventral region3.37
2.53
Itga2THThalamus2.07
2.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009227 14 1014 1027 AGDISCNADINPLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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