AutismKB 2.0

Annotation Detail for ITGA2B


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Basic Information Top
Gene Symbol:ITGA2B ( CD41,CD41B,GP2B,GPIIb,GTA,HPA3 )
Gene Full Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Band: 17q21.31
Quick LinksEntrez ID:3674; OMIM: 607759; Uniprot ID:ITA2B_HUMAN; ENSEMBL ID: ENSG00000005961; HGNC ID: 6138
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult15 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal20 / 33603075
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow9 / 48801184
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis4 / 33044212
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206493_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte5
AdrenalCortex5.7
Adrenalgland4.25
Amygdala5.1
Appendix5.2
AtrioventricularNode4.25
BDCA4+_DentriticCells5.65
Bonemarrow5.85
BronchialEpithelialCells4.85
CD105+_Endothelial8.6
CD14+_Monocytes35.5
CD19+_BCells(neg._sel.)8.15
CD33+_Myeloid8.3
CD34+1046.8
CD4+_Tcells7.15
CD56+_NKCells6.8
CD71+_EarlyErythroid5.6
CD8+_Tcells4.95
CardiacMyocytes6.6
Caudatenucleus4.45
Cerebellum4.05
CerebellumPeduncles5.7
CiliaryGanglion3.85
CingulateCortex5.2
Colorectaladenocarcinoma5.05
DorsalRootGanglion4.05
FetalThyroid4.8
Fetalbrain4.8
Fetalliver4.35
Fetallung4.35
GlobusPallidus4.65
Heart6.8
Hypothalamus5.3
Kidney4.25
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.4
Leukemialymphoblastic(MOLT-4)4
Liver6.5
Lung5.35
Lymphnode4.3
Lymphoma_burkitts(Daudi)6.6
Lymphoma_burkitts(Raji)7.35
MedullaOblongata4.6
OccipitalLobe4.5
OlfactoryBulb4.05
Ovary3.45
Pancreas4.05
PancreaticIslet5.35
ParietalLobe5.35
Pituitary5.85
Placenta5.05
Pons6.65
PrefrontalCortex6.2
Prostate5.85
Salivarygland4.1
SkeletalMuscle11.9
Skin5.75
SmoothMuscle5.45
Spinalcord5.35
SubthalamicNucleus4.65
SuperiorCervicalGanglion6.35
TemporalLobe5.55
Testis4.25
TestisGermCell4.2
TestisIntersitial4.3
TestisLeydigCell5.05
TestisSeminiferousTubule4.3
Thalamus5.1
Thymus3.75
Thyroid6.15
Tongue5.25
Tonsil4.9
Trachea4.2
TrigeminalGanglion7.65
Uterus4.05
UterusCorpus4.4
WholeBlood259.1
Wholebrain4
colon5
pineal_day9.86
pineal_night8.9
retina6.025
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P65373
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.42 ± 0.91
Basal Forebrain3.47 ± 0.56
Basal Part of Pons2.94 ± 0.85
Cerebellar Cortex3.43 ± 0.55
Cerebellar Nuclei3.42 ± 0.79
Claustrum3.7 ± 0.7
Epithalamus3.01 ± 0.77
Frontal Lobe3.08 ± 0.74
Globus Pallidus3.24 ± 0.93
Hypothalamus2.99 ± 0.42
Insula2.76 ± 0.95
Limbic Lobe3.26 ± 0.78
Mesencephalon3.22 ± 0.7
Myelencephalon3.19 ± 0.64
Occipital Lobe3.31 ± 0.72
Parietal Lobe3.01 ± 0.78
Pontine Tegmentum3.11 ± 0.66
Striatum3.2 ± 0.72
Subthalamus3.27 ± 0.43
Temporal Lobe3.1 ± 0.71
Thalamus3.09 ± 0.72
White Matter3.38 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itga2bCBCerebellum1.18
1.49
Itga2bCTXCerebral cortex2.42
0.95
Itga2bHIPHippocampal region0.45
0.34
Itga2bHPFHippocampal formation0.63
0.39
Itga2bHYHypothalamus0.58
0.26
Itga2bLSXLateral septal complex0.28
0.1
Itga2bMBMidbrain0.9
0.91
Itga2bMYMedulla1.74
1.07
Itga2bOLFOlfactory bulb6.08
3.9
Itga2bPPons1.4
0.9
Itga2bPALPallidum1.2
0.6
Itga2bRHPRetrohippocampal region1.06
0.52
Itga2bsAMYStriatum-like amygdalar nuclei2.26
0.69
Itga2bSTRStriatum1.05
0.37
Itga2bSTRdStriatum dorsal region0.91
0.37
Itga2bSTRvStriatum ventral region1.29
0.39
Itga2bTHThalamus0.77
0.37
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00093114 9 766 774 IVLLDVPVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018