AutismKB 2.0

Annotation Detail for ITGA4


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Basic Information Top
Gene Symbol:ITGA4 ( CD49D,IA4,MGC90518 )
Gene Full Name: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Band: 2q31.3
Quick LinksEntrez ID:3676; OMIM: 192975; Uniprot ID:ITA4_HUMAN; ENSEMBL ID: ENSG00000115232; HGNC ID: 6140
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus11 / 56401219
neonate3 / 3109796
infant1 / 2362042
juvenile2 / 5555635
adult46 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor15 / 26384556
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal73 / 336030721
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone1 / 7165513
bone marrow3 / 4880161
brain6 / 11009895
cervix0 / 481710 
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine4 / 23447217
kidney6 / 21177728
larynx0 / 241450 
liver7 / 20774333
lung2 / 3369745
lymph2 / 4427045
lymph node7 / 9161076
mammary gland1 / 1532716
mouth2 / 6705229
muscle4 / 10771537
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate4 / 18934521
salivary gland0 / 201550 
skin6 / 21057428
spleen5 / 5395292
stomach2 / 9661920
testis5 / 33044215
thymus29 / 81131357
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205884_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.3
Adipocyte6.15
AdrenalCortex7.35
Adrenalgland5.5
Amygdala6.15
Appendix7.4
AtrioventricularNode5.85
BDCA4+_DentriticCells99.4
Bonemarrow6.7
BronchialEpithelialCells5.9
CD105+_Endothelial49.1
CD14+_Monocytes43.55
CD19+_BCells(neg._sel.)20.2
CD33+_Myeloid50.45
CD34+56.25
CD4+_Tcells90.85
CD56+_NKCells38.45
CD71+_EarlyErythroid61.65
CD8+_Tcells96.9
CardiacMyocytes10.65
Caudatenucleus5.6
Cerebellum5.15
CerebellumPeduncles7.55
CiliaryGanglion5.15
CingulateCortex6.45
Colorectaladenocarcinoma6.25
DorsalRootGanglion5.3
FetalThyroid6.15
Fetalbrain6.05
Fetalliver20.4
Fetallung4.9
GlobusPallidus4.7
Heart9.35
Hypothalamus6.05
Kidney5.45
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.7
Leukemialymphoblastic(MOLT-4)40.8
Liver9.1
Lung6.8
Lymphnode7.95
Lymphoma_burkitts(Daudi)8.6
Lymphoma_burkitts(Raji)9.7
MedullaOblongata5.55
OccipitalLobe5.5
OlfactoryBulb4.9
Ovary4.45
Pancreas5.2
PancreaticIslet6.45
ParietalLobe6.8
Pituitary7.45
Placenta6.15
Pons6.15
PrefrontalCortex7.5
Prostate6.7
Salivarygland5.3
SkeletalMuscle10.45
Skin5.5
SmoothMuscle7.05
Spinalcord6.65
SubthalamicNucleus5.9
SuperiorCervicalGanglion13.55
TemporalLobe5.8
Testis5.35
TestisGermCell4.9
TestisIntersitial5.25
TestisLeydigCell6.35
TestisSeminiferousTubule5.4
Thalamus6
Thymus4.8
Thyroid7.35
Tongue7.1
Tonsil6.6
Trachea5.3
TrigeminalGanglion7.2
Uterus5.1
UterusCorpus6.15
WholeBlood36.4
Wholebrain4.7
colon5.9
pineal_day12.34
pineal_night16.82
retina7.45
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1403_PI416379584
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.18 ± 1.18
Basal Forebrain1.6 ± 0.27
Basal Part of Pons1.34 ± 0.45
Cerebellar Cortex2.97 ± 0.61
Cerebellar Nuclei2.05 ± 0.71
Claustrum2.83 ± 1.23
Epithalamus3.55 ± 1.46
Frontal Lobe1.64 ± 0.89
Globus Pallidus1.69 ± 0.75
Hypothalamus1.79 ± 0.66
Insula1.89 ± 0.74
Limbic Lobe2.01 ± 0.78
Mesencephalon1.97 ± 0.78
Myelencephalon1.89 ± 0.92
Occipital Lobe2.08 ± 0.8
Parietal Lobe1.76 ± 0.9
Pontine Tegmentum1.9 ± 0.84
Striatum1.69 ± 0.94
Subthalamus1.89 ± 0.63
Temporal Lobe1.73 ± 0.86
Thalamus1.65 ± 0.71
White Matter2.08 ± 0.56
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040908 24 93 116 IGKNPGQTCEQLQLGSPNGEPCGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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