AutismKB 2.0

Annotation Detail for ITGA5


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Basic Information Top
Gene Symbol:ITGA5 ( CD49e,FNRA,VLA5A )
Gene Full Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Band: 12q13.13
Quick LinksEntrez ID:3678; OMIM: 135620; Uniprot ID:ITA5_HUMAN; ENSEMBL ID: ENSG00000161638; HGNC ID: 6141
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body23 / 70761325
blastocyst10 / 62319160
fetus91 / 564012161
neonate34 / 310971093
infant0 / 236200 
juvenile2 / 5555635
adult383 / 1939121197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma16 / 17475915
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma31 / 82823374
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor2 / 11936916
germ cell tumor52 / 263845197
glioma10 / 10688393
head and neck tumor20 / 136302146
kidney tumor13 / 68959188
leukemia13 / 95842135
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal566 / 3360307168
ovarian tumor0 / 766820 
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder16 / 29757537
blood9 / 12347872
bone18 / 71655251
bone marrow16 / 48801327
brain49 / 110098944
cervix5 / 48171103
connective tissue22 / 149255147
ear0 / 162120 
embryonic tissue40 / 215722185
esophagus3 / 20209148
eye10 / 21105447
heart11 / 89626122
intestine29 / 234472123
kidney32 / 211777151
larynx8 / 24145331
liver9 / 20774343
lung75 / 336974222
lymph0 / 442700 
lymph node0 / 916100 
mammary gland10 / 15327165
mouth9 / 67052134
muscle19 / 107715176
nerve0 / 157680 
ovary4 / 10205139
pancreas18 / 21481283
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta159 / 280825566
prostate14 / 18934573
salivary gland0 / 201550 
skin22 / 210574104
spleen7 / 53952129
stomach2 / 9661920
testis41 / 330442124
thymus18 / 81131221
thyroid5 / 47473105
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord81 / 136805921
uterus87 / 232878373
vascular36 / 51780695
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201389_at
Cell line Expression level Expression bar
721_B_lymphoblasts144.45
Adipocyte546.95
AdrenalCortex210.8
Adrenalgland194.2
Amygdala89.05
Appendix426.2
AtrioventricularNode171.2
BDCA4+_DentriticCells125.2
Bonemarrow185.9
BronchialEpithelialCells462.5
CD105+_Endothelial114.7
CD14+_Monocytes551.35
CD19+_BCells(neg._sel.)95.75
CD33+_Myeloid499.25
CD34+370.95
CD4+_Tcells340.55
CD56+_NKCells430.9
CD71+_EarlyErythroid86.65
CD8+_Tcells231.5
CardiacMyocytes1136.5
Caudatenucleus96.7
Cerebellum122.55
CerebellumPeduncles179.8
CiliaryGanglion259.45
CingulateCortex124.7
Colorectaladenocarcinoma166.9
DorsalRootGanglion140.15
FetalThyroid365.55
Fetalbrain123.45
Fetalliver171
Fetallung378.35
GlobusPallidus103.9
Heart386.95
Hypothalamus143.1
Kidney127
Leukemia_chronicMyelogenousK-562248.15
Leukemia_promyelocytic-HL-6097.85
Leukemialymphoblastic(MOLT-4)146.5
Liver253
Lung485.75
Lymphnode196.35
Lymphoma_burkitts(Daudi)151.85
Lymphoma_burkitts(Raji)196.9
MedullaOblongata122.35
OccipitalLobe133.5
OlfactoryBulb181.3
Ovary243.3
Pancreas129.3
PancreaticIslet161.55
ParietalLobe154.5
Pituitary140.1
Placenta1596.5
Pons163.8
PrefrontalCortex136.1
Prostate445.95
Salivarygland123.75
SkeletalMuscle252.95
Skin219.8
SmoothMuscle1893.25
Spinalcord154.55
SubthalamicNucleus97.5
SuperiorCervicalGanglion291.85
TemporalLobe128.8
Testis122.85
TestisGermCell194.9
TestisIntersitial143.45
TestisLeydigCell237.05
TestisSeminiferousTubule228.1
Thalamus130
Thymus164.8
Thyroid144.55
Tongue210.2
Tonsil182.05
Trachea132.85
TrigeminalGanglion250.8
Uterus277.55
UterusCorpus265.15
WholeBlood750.7
Wholebrain84.9
colon370
pineal_day73.94
pineal_night62.92
retina206.95
small_intestine183.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13991_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.14 ± 0.98
Basal Forebrain1.67 ± 0.19
Basal Part of Pons1.37 ± 0.35
Cerebellar Cortex1.54 ± 0.64
Cerebellar Nuclei2.06 ± 0.74
Claustrum2.57 ± 0.82
Epithalamus1.46 ± 0.74
Frontal Lobe1.58 ± 0.58
Globus Pallidus2.38 ± 0.35
Hypothalamus1.72 ± 0.64
Insula1.62 ± 0.54
Limbic Lobe1.73 ± 0.67
Mesencephalon1.9 ± 0.64
Myelencephalon1.75 ± 0.61
Occipital Lobe1.76 ± 0.58
Parietal Lobe1.69 ± 0.61
Pontine Tegmentum1.79 ± 0.67
Striatum1.9 ± 0.54
Subthalamus1.91 ± 0.63
Temporal Lobe1.61 ± 0.55
Thalamus1.75 ± 0.52
White Matter2.56 ± 0.9
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itga5CBCerebellum4.62
6.52
Itga5CTXCerebral cortex4.92
3.8
Itga5HIPHippocampal region1.79
2.75
Itga5HPFHippocampal formation2.06
2.57
Itga5HYHypothalamus0.43
0.41
Itga5LSXLateral septal complex0.2
0.32
Itga5MBMidbrain1.69
2.2
Itga5MYMedulla5.47
6.91
Itga5OLFOlfactory bulb3.32
2.65
Itga5PPons4.9
5.89
Itga5PALPallidum1.26
1.11
Itga5RHPRetrohippocampal region2.45
2.33
Itga5sAMYStriatum-like amygdalar nuclei0.3
0.22
Itga5STRStriatum31.12
21.47
Itga5STRdStriatum dorsal region44.28
31.17
Itga5STRvStriatum ventral region12.97
8.28
Itga5THThalamus1.88
1.96
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITA5_HUMAN_0 0 0 0 VTAPPEAEYSGLVR PRIDE
ITA5_HUMAN_364 27 364 390 VYVYLQHPAGIEPTPTLTLTGHDEFGR PRIDE
ITA5_HUMAN_489 23 489 511 GRPIVSASASLTIFPAMFNPEER PRIDE
ITA5_HUMAN_567 15 567 581 QATLTQTLLIQNGAR PRIDE
PAp00009243 16 148 163 AHGSSILACAPLYSWR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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