AutismKB 2.0

Annotation Detail for ITGAL


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Basic Information Top
Gene Symbol:ITGAL ( CD11A,LFA-1,LFA1A )
Gene Full Name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Band: 16p11.2
Quick LinksEntrez ID:3683; OMIM: 153370; Uniprot ID:ITAL_HUMAN; ENSEMBL ID: ENSG00000005844; HGNC ID: 6148
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult53 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia16 / 95842166
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal108 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood21 / 123478170
bone0 / 716550 
bone marrow12 / 48801245
brain8 / 11009897
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung6 / 33697417
lymph5 / 44270112
lymph node34 / 91610371
mammary gland2 / 15327113
mouth3 / 6705244
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta3 / 28082510
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen24 / 53952444
stomach5 / 9661951
testis5 / 33044215
thymus47 / 81131579
thyroid2 / 4747342
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213475_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts47.45
Adipocyte35.4
AdrenalCortex64.3
Adrenalgland33.7
Amygdala20.9
Appendix34.25
AtrioventricularNode49.9
BDCA4+_DentriticCells132.95
Bonemarrow57.7
BronchialEpithelialCells28.85
CD105+_Endothelial37.7
CD14+_Monocytes204.9
CD19+_BCells(neg._sel.)85.65
CD33+_Myeloid423.45
CD34+98.3
CD4+_Tcells394.8
CD56+_NKCells829.3
CD71+_EarlyErythroid37.55
CD8+_Tcells551.7
CardiacMyocytes80.65
Caudatenucleus32.05
Cerebellum27.75
CerebellumPeduncles73.4
CiliaryGanglion59.1
CingulateCortex40.8
Colorectaladenocarcinoma32.1
DorsalRootGanglion35.2
FetalThyroid40.1
Fetalbrain30.95
Fetalliver30.5
Fetallung21
GlobusPallidus36.1
Heart74.85
Hypothalamus31.05
Kidney36.7
Leukemia_chronicMyelogenousK-56230.6
Leukemia_promyelocytic-HL-6029.95
Leukemialymphoblastic(MOLT-4)54.15
Liver61.85
Lung50.6
Lymphnode159.05
Lymphoma_burkitts(Daudi)65.1
Lymphoma_burkitts(Raji)93.4
MedullaOblongata27.5
OccipitalLobe37.7
OlfactoryBulb26.25
Ovary35.9
Pancreas36.1
PancreaticIslet38.45
ParietalLobe44.8
Pituitary52.75
Placenta33
Pons41.3
PrefrontalCortex31.75
Prostate32.2
Salivarygland38.85
SkeletalMuscle71.1
Skin26.75
SmoothMuscle45.25
Spinalcord40.15
SubthalamicNucleus42
SuperiorCervicalGanglion40.4
TemporalLobe37.7
Testis28.9
TestisGermCell26.05
TestisIntersitial34.85
TestisLeydigCell46.25
TestisSeminiferousTubule33.55
Thalamus42.45
Thymus69.85
Thyroid27.3
Tongue61.05
Tonsil104.25
Trachea29.45
TrigeminalGanglion43.65
Uterus19.7
UterusCorpus34.35
WholeBlood200.35
Wholebrain19.75
colon30.75
pineal_day32.64
pineal_night32.54
retina41.6
small_intestine30.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P206806
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.86 ± 1.07
Basal Forebrain2.32 ± 0.38
Basal Part of Pons2.46 ± 0.88
Cerebellar Cortex2.1 ± 0.65
Cerebellar Nuclei2.87 ± 0.73
Claustrum3.31 ± 0.82
Epithalamus2.78 ± 1
Frontal Lobe2.29 ± 0.78
Globus Pallidus4.19 ± 0.44
Hypothalamus2.46 ± 0.97
Insula2.63 ± 0.86
Limbic Lobe2.39 ± 0.86
Mesencephalon2.56 ± 0.79
Myelencephalon2.57 ± 0.79
Occipital Lobe2.34 ± 0.68
Parietal Lobe2.49 ± 0.84
Pontine Tegmentum2.4 ± 0.77
Striatum2.7 ± 0.75
Subthalamus2.9 ± 0.97
Temporal Lobe2.43 ± 0.81
Thalamus2.35 ± 0.69
White Matter3.91 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ItgalCBCerebellum6.34
8.34
ItgalCTXCerebral cortex4.5
3.45
ItgalHIPHippocampal region2.9
4.57
ItgalHPFHippocampal formation2.11
3.04
ItgalHYHypothalamus1.77
2.11
ItgalLSXLateral septal complex2
1.77
ItgalMBMidbrain1.49
2.16
ItgalMYMedulla1.51
1.68
ItgalOLFOlfactory bulb6.05
5.26
ItgalPPons1.11
1.56
ItgalPALPallidum3.78
3.44
ItgalRHPRetrohippocampal region0.77
0.9
ItgalsAMYStriatum-like amygdalar nuclei1.02
0.93
ItgalSTRStriatum3.9
3.56
ItgalSTRdStriatum dorsal region4.45
4.18
ItgalSTRvStriatum ventral region4.54
3.83
ItgalTHThalamus2.51
2.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITAL_HUMAN_225 21 225 245 HMLLLTNTFGAINYVATEVFR PRIDE
ITAL_HUMAN_225 32 225 256 HMLLLTNTFGAINYVATEVFREELGARPDATK PRIDE
ITAL_HUMAN_400 14 400 413 AGYLGYTVTWLPSR PRIDE
ITAL_HUMAN_416 10 416 425 TSLLASGAPR PRIDE
ITAL_HUMAN_568 15 568 582 IEGTQVLSGIQWFGR PRIDE
ITAL_HUMAN_748 21 748 768 DIPPILRPSLHSETWEIPFEK PRIDE
PAp00011625 16 118 133 TCDQNTYLSGLCYLFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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