AutismKB 2.0

Annotation Detail for ITGAM


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Basic Information Top
Gene Symbol:ITGAM ( CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6 )
Gene Full Name: integrin, alpha M (complement component 3 receptor 3 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3684; OMIM: 120980; Uniprot ID:ITAM_HUMAN; ENSEMBL ID: ENSG00000169896; HGNC ID: 6149
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia43 / 95842448
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal38 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood42 / 123478340
bone2 / 7165527
bone marrow21 / 48801430
brain6 / 11009895
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis1 / 3304423
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205786_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.3
Adipocyte8.75
AdrenalCortex9.85
Adrenalgland9.2
Amygdala11.8
Appendix9.25
AtrioventricularNode7.05
BDCA4+_DentriticCells107.15
Bonemarrow396.4
BronchialEpithelialCells8.7
CD105+_Endothelial14
CD14+_Monocytes457.4
CD19+_BCells(neg._sel.)9.9
CD33+_Myeloid1506.9
CD34+11.2
CD4+_Tcells16.45
CD56+_NKCells1070.8
CD71+_EarlyErythroid8
CD8+_Tcells63.55
CardiacMyocytes11.95
Caudatenucleus8.8
Cerebellum7.35
CerebellumPeduncles10.3
CiliaryGanglion6.65
CingulateCortex9.15
Colorectaladenocarcinoma9
DorsalRootGanglion7.35
FetalThyroid8.55
Fetalbrain8.75
Fetalliver7.85
Fetallung7.65
GlobusPallidus6.65
Heart13
Hypothalamus13.7
Kidney8.2
Leukemia_chronicMyelogenousK-5628.45
Leukemia_promyelocytic-HL-607.85
Leukemialymphoblastic(MOLT-4)7.2
Liver13.55
Lung95.55
Lymphnode14.8
Lymphoma_burkitts(Daudi)11.55
Lymphoma_burkitts(Raji)12.05
MedullaOblongata8.1
OccipitalLobe8.1
OlfactoryBulb7.65
Ovary6.25
Pancreas7.25
PancreaticIslet9.75
ParietalLobe10.3
Pituitary10.5
Placenta11.9
Pons8.95
PrefrontalCortex10.9
Prostate10.35
Salivarygland7.45
SkeletalMuscle12.05
Skin7.5
SmoothMuscle9.75
Spinalcord20.95
SubthalamicNucleus8.25
SuperiorCervicalGanglion12.9
TemporalLobe10.75
Testis7.75
TestisGermCell7.25
TestisIntersitial7.5
TestisLeydigCell8.95
TestisSeminiferousTubule7.6
Thalamus9.4
Thymus9.05
Thyroid11.2
Tongue9.9
Tonsil15.6
Trachea7.7
TrigeminalGanglion9.7
Uterus10.1
UterusCorpus8.6
WholeBlood749.6
Wholebrain10.15
colon9.55
pineal_day10.28
pineal_night10
retina13.425
small_intestine8.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15536_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.36 ± 1
Basal Forebrain1.71 ± 0.25
Basal Part of Pons1.4 ± 0.51
Cerebellar Cortex1.97 ± 0.79
Cerebellar Nuclei2.25 ± 0.75
Claustrum2.88 ± 1.04
Epithalamus1.64 ± 0.74
Frontal Lobe1.76 ± 0.66
Globus Pallidus2.53 ± 0.76
Hypothalamus2.04 ± 0.81
Insula1.6 ± 0.71
Limbic Lobe2.01 ± 0.76
Mesencephalon2.22 ± 0.71
Myelencephalon2.01 ± 0.69
Occipital Lobe2.26 ± 0.7
Parietal Lobe2.05 ± 0.82
Pontine Tegmentum2 ± 0.72
Striatum2.2 ± 0.72
Subthalamus2.03 ± 0.58
Temporal Lobe1.89 ± 0.71
Thalamus1.98 ± 0.65
White Matter1.98 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ItgamCBCerebellum2.33
3.16
ItgamCTXCerebral cortex4.67
3.11
ItgamHIPHippocampal region2.9
2.8
ItgamHPFHippocampal formation2.02
1.83
ItgamHYHypothalamus1.47
1.21
ItgamLSXLateral septal complex2.46
1.63
ItgamMBMidbrain1.9
2.72
ItgamMYMedulla1.26
1.91
ItgamOLFOlfactory bulb8.88
6.15
ItgamPPons0.51
0.68
ItgamPALPallidum1.98
1.43
ItgamRHPRetrohippocampal region0.82
0.74
ItgamsAMYStriatum-like amygdalar nuclei1.05
0.66
ItgamSTRStriatum2.08
1.72
ItgamSTRdStriatum dorsal region2.23
2.09
ItgamSTRvStriatum ventral region1.83
1.06
ItgamTHThalamus1.25
1.13
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITAM_HUMAN_0 0 0 0 GAVYLFHGTSGSGISPSHSQR PRIDE
ITAM_HUMAN_0 0 0 0 GFGQSVVQLQGSR PRIDE
ITAM_HUMAN_0 0 0 0 GGQVSVCPLPR PRIDE
ITAM_HUMAN_0 0 0 0 GLCFLFGSNLR PRIDE
ITAM_HUMAN_0 0 0 0 LACESASSTEVSGALK PRIDE
ITAM_HUMAN_0 0 0 0 LFTALFPFEK PRIDE
ITAM_HUMAN_0 0 0 0 LQLPNCIEDPVSPIVLR PRIDE
ITAM_HUMAN_0 0 0 0 LTDVAIGAPGEEDNR PRIDE
ITAM_HUMAN_0 0 0 0 NVFECNDQVVK PRIDE
ITAM_HUMAN_0 0 0 0 SLPISLVFLVPVR PRIDE
ITAM_HUMAN_0 0 0 0 SLVKPITQLLGR PRIDE
ITAM_HUMAN_0 0 0 0 SRQELNTIASKPPR PRIDE
ITAM_HUMAN_0 0 0 0 VQSLVLGAPR PRIDE
ITAM_HUMAN_0 0 0 0 VVVGAPQEIVAANQR PRIDE
ITAM_HUMAN_1001 14 1001 1014 ERLPSHSDFLAELR PRIDE
ITAM_HUMAN_120 11 120 130 GLCFLFGSNLR PRIDE
ITAM_HUMAN_168 14 168 181 MKEFVSTVMEQLKK PRIDE
ITAM_HUMAN_184 13 184 196 TLFSLMQYSEEFR PRIDE
ITAM_HUMAN_212 12 212 223 SLVKPITQLLGR PRIDE
ITAM_HUMAN_251 10 251 260 ILVVITDGEK PRIDE
ITAM_HUMAN_261 21 261 281 FGDPLGYEDVIPEADREGVIR PRIDE
ITAM_HUMAN_282 10 282 291 YVIGVGDAFR PRIDE
ITAM_HUMAN_32 13 32 44 GFGQSVVQLQGSR PRIDE
ITAM_HUMAN_415 10 415 424 VQSLVLGAPR PRIDE
ITAM_HUMAN_45 15 45 59 VVVGAPQEIVAANQR PRIDE
ITAM_HUMAN_487 11 487 497 GGQVSVCPLPR PRIDE
ITAM_HUMAN_549 21 549 569 GAVYLFHGTSGSGISPSHSQR PRIDE
ITAM_HUMAN_633 11 633 643 NVFECNDQVVK PRIDE
ITAM_HUMAN_666 22 666 687 EGQIQSVVTYDLALDSGRPHSR PRIDE
ITAM_HUMAN_700 15 700 714 QTQVLGLTQTCETLK PRIDE
ITAM_HUMAN_715 17 715 731 LQLPNCIEDPVSPIVLR PRIDE
ITAM_HUMAN_758 10 758 767 LFTALFPFEK PRIDE
ITAM_HUMAN_815 14 815 828 TQVTFFFPLDLSYR PRIDE
ITAM_HUMAN_815 15 815 829 TQVTFFFPLDLSYRK PRIDE
ITAM_HUMAN_844 16 844 859 LACESASSTEVSGALK PRIDE
ITAM_HUMAN_922 15 922 936 YAVYMVVTSHGVSTK PRIDE
ITAM_HUMAN_949 14 949 962 VMQHQYQVSNLGQR PRIDE
ITAM_HUMAN_963 13 963 975 SLPISLVFLVPVR PRIDE
PAp00032991 13 310 322 DHVFQVNNFEALK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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