AutismKB 2.0

Annotation Detail for ITGAX


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Basic Information Top
Gene Symbol:ITGAX ( CD11C,SLEB6 )
Gene Full Name: integrin, alpha X (complement component 3 receptor 4 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3687; OMIM: 151510; Uniprot ID:ITAX_HUMAN; ENSEMBL ID: ENSG00000140678; HGNC ID: 6152
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate6 / 31097192
infant0 / 236200 
juvenile0 / 555560 
adult25 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood17 / 123478137
bone0 / 716550 
bone marrow7 / 48801143
brain18 / 110098916
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx2 / 2414582
liver0 / 2077430 
lung7 / 33697420
lymph0 / 442700 
lymph node7 / 9161076
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland1 / 2015549
skin0 / 2105740 
spleen3 / 5395255
stomach3 / 9661931
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210184_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.75
Adipocyte4.5
AdrenalCortex4.7
Adrenalgland3.8
Amygdala4.85
Appendix4.45
AtrioventricularNode3.4
BDCA4+_DentriticCells9.5
Bonemarrow4.5
BronchialEpithelialCells4.4
CD105+_Endothelial4.55
CD14+_Monocytes57.25
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid32.85
CD34+5.85
CD4+_Tcells4.9
CD56+_NKCells45.3
CD71+_EarlyErythroid4.2
CD8+_Tcells4.2
CardiacMyocytes5.4
Caudatenucleus4.1
Cerebellum3.85
CerebellumPeduncles5.35
CiliaryGanglion3.1
CingulateCortex4.6
Colorectaladenocarcinoma4.5
DorsalRootGanglion3.45
FetalThyroid4.35
Fetalbrain4.5
Fetalliver3.9
Fetallung3.8
GlobusPallidus3.25
Heart5.65
Hypothalamus5.4
Kidney3.6
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.6
Liver6.35
Lung7.45
Lymphnode24.35
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)7.4
MedullaOblongata4.45
OccipitalLobe4.1
OlfactoryBulb3.6
Ovary2.95
Pancreas3.6
PancreaticIslet4.85
ParietalLobe4.7
Pituitary5.35
Placenta4.6
Pons5
PrefrontalCortex5.65
Prostate5
Salivarygland3.8
SkeletalMuscle5.2
Skin3.4
SmoothMuscle4.85
Spinalcord7.3
SubthalamicNucleus4.1
SuperiorCervicalGanglion5
TemporalLobe4.1
Testis3.95
TestisGermCell3.75
TestisIntersitial3.65
TestisLeydigCell4.45
TestisSeminiferousTubule3.85
Thalamus4.65
Thymus3.35
Thyroid5.35
Tongue4.35
Tonsil6.75
Trachea3.75
TrigeminalGanglion4.4
Uterus3.65
UterusCorpus4.3
WholeBlood51.15
Wholebrain3.8
colon4.55
pineal_day5.62
pineal_night6
retina5.5
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P312132
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.76 ± 0.7
Basal Forebrain3.71 ± 1.07
Basal Part of Pons4.86 ± 0.59
Cerebellar Cortex3.21 ± 0.66
Cerebellar Nuclei5.59 ± 0.59
Claustrum3.57 ± 0.94
Epithalamus4.92 ± 0.61
Frontal Lobe3.68 ± 0.75
Globus Pallidus5.73 ± 0.52
Hypothalamus3.88 ± 1.24
Insula3.78 ± 0.63
Limbic Lobe3.49 ± 0.7
Mesencephalon3.73 ± 0.89
Myelencephalon3.79 ± 0.95
Occipital Lobe3.19 ± 1.01
Parietal Lobe3.74 ± 0.73
Pontine Tegmentum3.57 ± 0.63
Striatum4.21 ± 0.61
Subthalamus4.71 ± 0.81
Temporal Lobe4.03 ± 0.77
Thalamus3.85 ± 0.66
White Matter5.92 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ItgaxCBCerebellum5.11
7.38
ItgaxCTXCerebral cortex4.96
5
ItgaxHIPHippocampal region2.26
2.95
ItgaxHPFHippocampal formation2.16
2.58
ItgaxHYHypothalamus1.7
1.86
ItgaxLSXLateral septal complex1.41
0.99
ItgaxMBMidbrain3.21
3.61
ItgaxMYMedulla13.36
13.19
ItgaxOLFOlfactory bulb9.43
7.14
ItgaxPPons4.51
4.62
ItgaxPALPallidum2.52
2.13
ItgaxRHPRetrohippocampal region1.97
1.87
ItgaxsAMYStriatum-like amygdalar nuclei1.99
1.92
ItgaxSTRStriatum2.3
2.26
ItgaxSTRdStriatum dorsal region1.52
1.64
ItgaxSTRvStriatum ventral region5.41
4.65
ItgaxTHThalamus3.67
4.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITAX_HUMAN_0 0 0 0 AVIFTQVSR PRIDE
ITAX_HUMAN_0 0 0 0 GAVYLFHGVLGPSISPSHSQR PRIDE
ITAX_HUMAN_0 0 0 0 GGQVSVCPLPR PRIDE
ITAX_HUMAN_0 0 0 0 GVQSLVLGAPR PRIDE
ITAX_HUMAN_0 0 0 0 SSNPLSLLASVHQLQGFTYTATAIQNVVHR PRIDE
ITAX_HUMAN_0 0 0 0 TTFQLELPVK PRIDE
ITAX_HUMAN_0 0 0 0 YFTASLPFEK PRIDE
PAp00492319 11 489 499 GGQVSVCPLPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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