AutismKB 2.0

Annotation Detail for ITGB1


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Basic Information Top
Gene Symbol:ITGB1 ( CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB )
Gene Full Name: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Band: 10p11.22
Quick LinksEntrez ID:3688; OMIM: 135630; Uniprot ID:ITB1_HUMAN; ENSEMBL ID: ENSG00000150093; HGNC ID: 6153
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body101 / 707611427
blastocyst25 / 62319401
fetus62 / 564012109
neonate30 / 31097964
infant0 / 236200 
juvenile7 / 55556125
adult516 / 1939121266
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma5 / 17475286
breast (mammary gland) tumor17 / 94178180
cervical tumor4 / 34366116
chondrosarcoma10 / 82823120
colorectal tumor30 / 114246262
esophageal tumor1 / 1729057
gastrointestinal tumor43 / 119369360
germ cell tumor54 / 263845204
glioma8 / 10688374
head and neck tumor34 / 136302249
kidney tumor9 / 68959130
leukemia7 / 9584273
liver tumor17 / 96359176
lung tumor10 / 10312796
lymphoma6 / 7175583
non-neoplasia43 / 97250442
normal834 / 3360307248
ovarian tumor8 / 76682104
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer22 / 102680214
retinoblastoma2 / 4635643
skin tumor15 / 124949120
soft tissue/muscle tissue tumor69 / 125191551
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites22 / 40015549
bladder8 / 29757268
blood9 / 12347872
bone19 / 71655265
bone marrow9 / 48801184
brain158 / 1100989143
cervix4 / 4817183
connective tissue115 / 149255770
ear7 / 16212431
embryonic tissue146 / 215722676
esophagus1 / 2020949
eye21 / 21105499
heart18 / 89626200
intestine50 / 234472213
kidney42 / 211777198
larynx3 / 24145124
liver38 / 207743182
lung63 / 336974186
lymph3 / 4427067
lymph node6 / 9161065
mammary gland29 / 153271189
mouth28 / 67052417
muscle83 / 107715770
nerve5 / 15768317
ovary10 / 10205197
pancreas55 / 214812256
parathyroid6 / 20539292
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta71 / 280825252
prostate30 / 189345158
salivary gland4 / 20155198
skin63 / 210574299
spleen7 / 53952129
stomach17 / 96619175
testis73 / 330442220
thymus8 / 8113198
thyroid5 / 47473105
tonsil0 / 169990 
trachea39 / 52413744
umbilical cord13 / 13680950
uterus69 / 232878296
vascular50 / 51780965
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211945_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.8
Adipocyte2012.2
AdrenalCortex556.65
Adrenalgland392.05
Amygdala156.05
Appendix579.8
AtrioventricularNode157.55
BDCA4+_DentriticCells736.7
Bonemarrow30.3
BronchialEpithelialCells2844.2
CD105+_Endothelial730.85
CD14+_Monocytes608.9
CD19+_BCells(neg._sel.)657.15
CD33+_Myeloid752.95
CD34+632.35
CD4+_Tcells925.8
CD56+_NKCells1376.55
CD71+_EarlyErythroid477.15
CD8+_Tcells432.35
CardiacMyocytes2878.25
Caudatenucleus146.85
Cerebellum5.8
CerebellumPeduncles10.25
CiliaryGanglion254.6
CingulateCortex56.2
Colorectaladenocarcinoma272.85
DorsalRootGanglion283.35
FetalThyroid712.2
Fetalbrain86.1
Fetalliver637.25
Fetallung1467.1
GlobusPallidus16.85
Heart19.5
Hypothalamus430.7
Kidney174.8
Leukemia_chronicMyelogenousK-562300
Leukemia_promyelocytic-HL-60271.15
Leukemialymphoblastic(MOLT-4)203.25
Liver6.15
Lung383.9
Lymphnode717.95
Lymphoma_burkitts(Daudi)408.85
Lymphoma_burkitts(Raji)83
MedullaOblongata71.4
OccipitalLobe83.8
OlfactoryBulb712.55
Ovary383.6
Pancreas816
PancreaticIslet1064.8
ParietalLobe28.65
Pituitary738.05
Placenta1169.35
Pons18.8
PrefrontalCortex302.25
Prostate826.9
Salivarygland457.1
SkeletalMuscle54.5
Skin253.9
SmoothMuscle5537.9
Spinalcord588.05
SubthalamicNucleus17.05
SuperiorCervicalGanglion56.7
TemporalLobe20.25
Testis151.85
TestisGermCell765.7
TestisIntersitial325.5
TestisLeydigCell237.9
TestisSeminiferousTubule264.6
Thalamus163.8
Thymus130.65
Thyroid1183.45
Tongue147.25
Tonsil196.45
Trachea439.55
TrigeminalGanglion64.75
Uterus2057.7
UterusCorpus1113.9
WholeBlood903.8
Wholebrain42.95
colon1692.55
pineal_day117.78
pineal_night145.58
retina512.525
small_intestine1416.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P95397
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.42 ± 0.38
Basal Forebrain10.17 ± 0.34
Basal Part of Pons9.6 ± 0.32
Cerebellar Cortex9.7 ± 0.14
Cerebellar Nuclei10.95 ± 0.33
Claustrum9.34 ± 0.33
Epithalamus10.3 ± 0.47
Frontal Lobe10.02 ± 0.46
Globus Pallidus11.4 ± 0.19
Hypothalamus10.38 ± 0.65
Insula9.75 ± 0.07
Limbic Lobe9.77 ± 0.41
Mesencephalon10.27 ± 0.49
Myelencephalon10.12 ± 0.44
Occipital Lobe10.35 ± 0.49
Parietal Lobe9.96 ± 0.38
Pontine Tegmentum10.24 ± 0.4
Striatum10.71 ± 0.44
Subthalamus10.48 ± 0.19
Temporal Lobe9.79 ± 0.36
Thalamus10.24 ± 0.33
White Matter11.68 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itgb1CBCerebellum20.92
32.8
Itgb1CTXCerebral cortex25.24
20.28
Itgb1HIPHippocampal region14.98
19.48
Itgb1HPFHippocampal formation13.52
17.02
Itgb1HYHypothalamus18.36
15.19
Itgb1LSXLateral septal complex18.27
16.79
Itgb1MBMidbrain13.14
16.39
Itgb1MYMedulla16.32
24.73
Itgb1OLFOlfactory bulb24.88
23.61
Itgb1PPons12.81
19.95
Itgb1PALPallidum18.3
22.85
Itgb1RHPRetrohippocampal region11.48
14.06
Itgb1sAMYStriatum-like amygdalar nuclei9.14
10.7
Itgb1STRStriatum14.15
14.66
Itgb1STRdStriatum dorsal region15.2
16.31
Itgb1STRvStriatum ventral region10.93
9.99
Itgb1THThalamus17.89
18.96
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITB1_HUMAN_163 11 163 173 SLGTDLMNEMR PRIDE
ITB1_HUMAN_164 11 164 174 SLGTDLMNEMR PRIDE
ITB1_HUMAN_181 9 181 189 IGFGSFVEK PRIDE
ITB1_HUMAN_190 12 190 201 TVMPYISTTPAK PRIDE
ITB1_HUMAN_191 12 191 202 TVMPYISTTPAK PRIDE
ITB1_HUMAN_220 18 220 237 NVLSLTNKGEVFNELVGK PRIDE
ITB1_HUMAN_273 17 273 289 LLVFSTDAGFHFAGDGK PRIDE
ITB1_HUMAN_325 21 325 345 LSENNIQTIFAVTEEFQPVYK PRIDE
ITB1_HUMAN_388 10 388 397 LSEGVTISYK PRIDE
ITB1_HUMAN_784 10 784 793 SAVTTVVNPK PRIDE
PAp00000285 19 138 156 AEDYPIDLYYLMDLSYSMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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