AutismKB 2.0

Annotation Detail for ARAF


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Basic Information Top
Gene Symbol:ARAF ( A-RAF,ARAF1,PKS2,RAFA1 )
Gene Full Name: v-raf murine sarcoma 3611 viral oncogene homolog
Band: Xp11.3
Quick LinksEntrez ID:369; OMIM: 311010; Uniprot ID:ARAF_HUMAN; ENSEMBL ID: ENSG00000078061; HGNC ID: 646
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus26 / 56401246
neonate4 / 31097128
infant0 / 236200 
juvenile13 / 55556233
adult202 / 1939121104
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor14 / 94178148
cervical tumor11 / 34366320
chondrosarcoma6 / 8282372
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor13 / 119369108
germ cell tumor27 / 263845102
glioma16 / 106883149
head and neck tumor9 / 13630266
kidney tumor11 / 68959159
leukemia6 / 9584262
liver tumor4 / 9635941
lung tumor17 / 103127164
lymphoma9 / 71755125
non-neoplasia11 / 97250113
normal301 / 336030789
ovarian tumor7 / 7668291
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor14 / 124949112
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites5 / 40015124
bladder3 / 29757100
blood20 / 123478161
bone6 / 7165583
bone marrow2 / 4880140
brain91 / 110098982
cervix24 / 48171498
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus1 / 2020949
eye13 / 21105461
heart8 / 8962689
intestine31 / 234472132
kidney23 / 211777108
larynx0 / 241450 
liver16 / 20774377
lung30 / 33697489
lymph3 / 4427067
lymph node4 / 9161043
mammary gland23 / 153271150
mouth8 / 67052119
muscle7 / 10771564
nerve0 / 157680 
ovary9 / 10205188
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta25 / 28082589
prostate24 / 189345126
salivary gland4 / 20155198
skin25 / 210574118
spleen15 / 53952278
stomach5 / 9661951
testis18 / 33044254
thymus19 / 81131234
thyroid1 / 4747321
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord2 / 13680146
uterus26 / 232878111
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201895_at
Cell line Expression level Expression bar
721_B_lymphoblasts96.9
Adipocyte70.8
AdrenalCortex78.2
Adrenalgland62.8
Amygdala39.35
Appendix60.45
AtrioventricularNode50.3
BDCA4+_DentriticCells138.35
Bonemarrow107.7
BronchialEpithelialCells64.6
CD105+_Endothelial62.5
CD14+_Monocytes141.8
CD19+_BCells(neg._sel.)93.05
CD33+_Myeloid221.8
CD34+118.1
CD4+_Tcells149.75
CD56+_NKCells222.45
CD71+_EarlyErythroid72.85
CD8+_Tcells161.1
CardiacMyocytes66.45
Caudatenucleus57.55
Cerebellum54.5
CerebellumPeduncles73.05
CiliaryGanglion42.95
CingulateCortex66.35
Colorectaladenocarcinoma129.5
DorsalRootGanglion47.85
FetalThyroid69.2
Fetalbrain44.9
Fetalliver61.8
Fetallung78.4
GlobusPallidus29.75
Heart206.35
Hypothalamus59.25
Kidney83.15
Leukemia_chronicMyelogenousK-56260.85
Leukemia_promyelocytic-HL-6058.7
Leukemialymphoblastic(MOLT-4)52.05
Liver368.25
Lung153.55
Lymphnode72.55
Lymphoma_burkitts(Daudi)85.4
Lymphoma_burkitts(Raji)98
MedullaOblongata54.25
OccipitalLobe43.6
OlfactoryBulb62.85
Ovary48.6
Pancreas70.15
PancreaticIslet111.6
ParietalLobe44.3
Pituitary79.55
Placenta104.2
Pons64.15
PrefrontalCortex61.8
Prostate98.35
Salivarygland55.85
SkeletalMuscle86.05
Skin53.95
SmoothMuscle74.35
Spinalcord70.95
SubthalamicNucleus49.9
SuperiorCervicalGanglion68.6
TemporalLobe36.2
Testis56.7
TestisGermCell49.85
TestisIntersitial50.35
TestisLeydigCell63.55
TestisSeminiferousTubule53.1
Thalamus50.7
Thymus91
Thyroid141.35
Tongue68.3
Tonsil74.05
Trachea77.45
TrigeminalGanglion55.8
Uterus56.85
UterusCorpus54
WholeBlood130.65
Wholebrain36.4
colon84
pineal_day45.66
pineal_night39.62
retina87.9
small_intestine67.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P73511
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.76 ± 0.63
Basal Forebrain4.23 ± 0.36
Basal Part of Pons3.7 ± 0.57
Cerebellar Cortex4.3 ± 0.45
Cerebellar Nuclei4.18 ± 0.67
Claustrum3.72 ± 0.82
Epithalamus4.42 ± 0.36
Frontal Lobe3.85 ± 0.58
Globus Pallidus4.62 ± 0.57
Hypothalamus3.74 ± 0.52
Insula3.79 ± 0.28
Limbic Lobe3.59 ± 0.61
Mesencephalon4.04 ± 0.66
Myelencephalon4.02 ± 0.59
Occipital Lobe4.07 ± 0.65
Parietal Lobe3.89 ± 0.49
Pontine Tegmentum3.9 ± 0.62
Striatum4.12 ± 0.67
Subthalamus4.07 ± 0.68
Temporal Lobe3.72 ± 0.59
Thalamus4.19 ± 0.52
White Matter5.25 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ArafCBCerebellum0
0
ArafCTXCerebral cortex0
0
ArafHIPHippocampal region0
0
ArafHPFHippocampal formation0
0
ArafHYHypothalamus0
0
ArafLSXLateral septal complex0
0
ArafMBMidbrain0
0
ArafMYMedulla0
0
ArafOLFOlfactory bulb0
0
ArafPPons0
0
ArafPALPallidum0
0
ArafRHPRetrohippocampal region0
0
ArafsAMYStriatum-like amygdalar nuclei0
0
ArafSTRStriatum0
0
ArafSTRdStriatum dorsal region0
0
ArafSTRvStriatum ventral region0
0
ArafTHThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARAF_HUMAN_589 15 589 603 TQADELPACLLSAAR PRIDE
PAp00040268 8 132 139 FHQHCSSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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