AutismKB 2.0

Annotation Detail for ITGB3


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Basic Information Top
Gene Symbol:ITGB3 ( CD61,GP3A,GPIIIa )
Gene Full Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Band: 17q21.32
Quick LinksEntrez ID:3690; OMIM: 173470; Uniprot ID:ITB3_HUMAN; ENSEMBL ID: ENSG00000056345; HGNC ID: 6156
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus6 / 56401210
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor18 / 68959261
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal73 / 336030721
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine2 / 2344728
kidney32 / 211777151
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node2 / 9161021
mammary gland5 / 15327132
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate2 / 18934510
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid8 / 47473168
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204628_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.4
Adipocyte13.15
AdrenalCortex19.35
Adrenalgland11.15
Amygdala11.7
Appendix13.5
AtrioventricularNode12.55
BDCA4+_DentriticCells14.2
Bonemarrow12.95
BronchialEpithelialCells12.3
CD105+_Endothelial13.25
CD14+_Monocytes14.4
CD19+_BCells(neg._sel.)14.25
CD33+_Myeloid16
CD34+16.75
CD4+_Tcells14.45
CD56+_NKCells16.1
CD71+_EarlyErythroid12.4
CD8+_Tcells8.3
CardiacMyocytes17.5
Caudatenucleus14.1
Cerebellum10.35
CerebellumPeduncles16.15
CiliaryGanglion12.3
CingulateCortex14
Colorectaladenocarcinoma13.15
DorsalRootGanglion21.35
FetalThyroid13.25
Fetalbrain13
Fetalliver11.35
Fetallung11
GlobusPallidus13
Heart16.65
Hypothalamus14.5
Kidney17.4
Leukemia_chronicMyelogenousK-56211.1
Leukemia_promyelocytic-HL-6011.7
Leukemialymphoblastic(MOLT-4)10.75
Liver17.3
Lung9.7
Lymphnode11.05
Lymphoma_burkitts(Daudi)17.25
Lymphoma_burkitts(Raji)18.65
MedullaOblongata15.5
OccipitalLobe12
OlfactoryBulb10.5
Ovary9.45
Pancreas11.7
PancreaticIslet14.2
ParietalLobe15.15
Pituitary15.5
Placenta13.4
Pons27.25
PrefrontalCortex16.2
Prostate11.25
Salivarygland13.6
SkeletalMuscle19.7
Skin13.95
SmoothMuscle15.15
Spinalcord14.2
SubthalamicNucleus13
SuperiorCervicalGanglion20.3
TemporalLobe14.1
Testis9.45
TestisGermCell11
TestisIntersitial11.15
TestisLeydigCell15.35
TestisSeminiferousTubule11.4
Thalamus13.75
Thymus8.75
Thyroid20.2
Tongue15.6
Tonsil12.9
Trachea12.75
TrigeminalGanglion18.6
Uterus10.7
UterusCorpus11.75
WholeBlood52
Wholebrain7
colon13.35
pineal_day16.26
pineal_night14.08
retina17.625
small_intestine12.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P38519
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.39 ± 0.97
Basal Forebrain2.08 ± 0.34
Basal Part of Pons1.68 ± 0.33
Cerebellar Cortex1.83 ± 0.65
Cerebellar Nuclei2.37 ± 0.74
Claustrum2.89 ± 0.9
Epithalamus1.73 ± 0.73
Frontal Lobe1.82 ± 0.58
Globus Pallidus2.53 ± 0.34
Hypothalamus2.04 ± 0.52
Insula2.03 ± 0.75
Limbic Lobe2 ± 0.65
Mesencephalon2.2 ± 0.77
Myelencephalon2.02 ± 0.66
Occipital Lobe2.53 ± 0.93
Parietal Lobe1.92 ± 0.59
Pontine Tegmentum2.06 ± 0.69
Striatum2.27 ± 0.78
Subthalamus2.1 ± 0.62
Temporal Lobe1.85 ± 0.55
Thalamus1.94 ± 0.54
White Matter2.52 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itgb3CBCerebellum1.9
2.32
Itgb3CTXCerebral cortex3.25
2.44
Itgb3HIPHippocampal region1.06
0.99
Itgb3HPFHippocampal formation1.7
1.5
Itgb3HYHypothalamus0.17
0.25
Itgb3LSXLateral septal complex0.13
0.12
Itgb3MBMidbrain0.25
0.37
Itgb3MYMedulla1.22
1.24
Itgb3OLFOlfactory bulb2.02
1.57
Itgb3PPons0.43
0.52
Itgb3PALPallidum0.66
1.27
Itgb3RHPRetrohippocampal region2.66
2.13
Itgb3sAMYStriatum-like amygdalar nuclei0.22
0.24
Itgb3STRStriatum0.35
0.41
Itgb3STRdStriatum dorsal region0.31
0.31
Itgb3STRvStriatum ventral region0.62
0.93
Itgb3THThalamus0.67
1.61
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITB3_HUMAN_170 7 170 176 KLTSNLR PRIDE
PAp00136665 25 89 113 VLEDRPLSDKGSGDSSQVTQVSPQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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