AutismKB 2.0

Annotation Detail for ITGB5


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Basic Information Top
Gene Symbol:ITGB5 ( FLJ26658 )
Gene Full Name: integrin, beta 5
Band: 3q21.2
Quick LinksEntrez ID:3693; OMIM: 147561; Uniprot ID:ITB5_HUMAN; ENSEMBL ID: ENSG00000082781; HGNC ID: 6160
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst6 / 6231996
fetus39 / 56401269
neonate1 / 3109732
infant0 / 236200 
juvenile7 / 55556125
adult276 / 1939121142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor26 / 94178276
cervical tumor4 / 34366116
chondrosarcoma41 / 82823495
colorectal tumor19 / 114246166
esophageal tumor3 / 17290173
gastrointestinal tumor6 / 11936950
germ cell tumor21 / 26384579
glioma10 / 10688393
head and neck tumor43 / 136302315
kidney tumor24 / 68959348
leukemia1 / 9584210
liver tumor10 / 96359103
lung tumor26 / 103127252
lymphoma0 / 717550 
non-neoplasia14 / 97250143
normal268 / 336030779
ovarian tumor49 / 76682639
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor22 / 124949176
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites2 / 4001549
bladder1 / 2975733
blood2 / 12347816
bone10 / 71655139
bone marrow3 / 4880161
brain51 / 110098946
cervix4 / 4817183
connective tissue29 / 149255194
ear0 / 162120 
embryonic tissue20 / 21572292
esophagus3 / 20209148
eye23 / 211054108
heart4 / 8962644
intestine30 / 234472127
kidney37 / 211777174
larynx3 / 24145124
liver18 / 20774386
lung84 / 336974249
lymph0 / 442700 
lymph node0 / 916100 
mammary gland33 / 153271215
mouth30 / 67052447
muscle6 / 10771555
nerve1 / 1576863
ovary54 / 102051529
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta50 / 280825178
prostate13 / 18934568
salivary gland6 / 20155297
skin36 / 210574170
spleen7 / 53952129
stomach3 / 9661931
testis14 / 33044242
thymus6 / 8113173
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus28 / 232878120
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201125_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte392
AdrenalCortex12.2
Adrenalgland17.15
Amygdala14.95
Appendix13
AtrioventricularNode8.2
BDCA4+_DentriticCells7.4
Bonemarrow9.4
BronchialEpithelialCells127.25
CD105+_Endothelial12.45
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)6
CD33+_Myeloid7.15
CD34+7.2
CD4+_Tcells5.2
CD56+_NKCells6.65
CD71+_EarlyErythroid5.25
CD8+_Tcells4.85
CardiacMyocytes119.5
Caudatenucleus15.15
Cerebellum10.15
CerebellumPeduncles20.05
CiliaryGanglion7.55
CingulateCortex15.75
Colorectaladenocarcinoma1743.3
DorsalRootGanglion8.8
FetalThyroid11.95
Fetalbrain9.2
Fetalliver6.95
Fetallung13.2
GlobusPallidus6.25
Heart27.95
Hypothalamus24.7
Kidney35.15
Leukemia_chronicMyelogenousK-56250.65
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)6.25
Liver35.6
Lung124.8
Lymphnode8.6
Lymphoma_burkitts(Daudi)9.7
Lymphoma_burkitts(Raji)8.5
MedullaOblongata8.7
OccipitalLobe9.1
OlfactoryBulb75.35
Ovary4.5
Pancreas13.55
PancreaticIslet12.95
ParietalLobe8.15
Pituitary15.4
Placenta136.35
Pons10.45
PrefrontalCortex12.2
Prostate54.45
Salivarygland10.35
SkeletalMuscle9.65
Skin9.8
SmoothMuscle162
Spinalcord15.55
SubthalamicNucleus6.85
SuperiorCervicalGanglion8.9
TemporalLobe10.05
Testis7.65
TestisGermCell19.7
TestisIntersitial9.25
TestisLeydigCell7.25
TestisSeminiferousTubule9.55
Thalamus12.35
Thymus8.7
Thyroid30.65
Tongue21.5
Tonsil7.6
Trachea27.3
TrigeminalGanglion10.3
Uterus35.65
UterusCorpus112.45
WholeBlood15.05
Wholebrain20.95
colon15.85
pineal_day11.32
pineal_night18.48
retina104.15
small_intestine17.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13797_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.45 ± 0.84
Basal Forebrain2.29 ± 0.88
Basal Part of Pons1.78 ± 0.52
Cerebellar Cortex2.59 ± 0.72
Cerebellar Nuclei2.67 ± 1.1
Claustrum2.58 ± 0.77
Epithalamus2.98 ± 0.76
Frontal Lobe2.26 ± 0.74
Globus Pallidus3.49 ± 1.11
Hypothalamus1.98 ± 0.71
Insula2.22 ± 0.75
Limbic Lobe2.09 ± 0.76
Mesencephalon2.6 ± 0.82
Myelencephalon2.41 ± 0.82
Occipital Lobe2.26 ± 0.81
Parietal Lobe2.35 ± 0.87
Pontine Tegmentum2.3 ± 0.68
Striatum2.63 ± 0.68
Subthalamus2.22 ± 0.41
Temporal Lobe2.15 ± 0.8
Thalamus2.51 ± 0.69
White Matter2.19 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itgb5CBCerebellum46.15
59.18
Itgb5CTXCerebral cortex23.69
15.35
Itgb5HIPHippocampal region21.95
18.49
Itgb5HPFHippocampal formation21.64
16.51
Itgb5HYHypothalamus11.57
10.72
Itgb5LSXLateral septal complex18.95
15.94
Itgb5MBMidbrain12.13
12.76
Itgb5MYMedulla15.26
25.23
Itgb5OLFOlfactory bulb24.54
15.56
Itgb5PPons22.89
33.22
Itgb5PALPallidum15.16
9.9
Itgb5RHPRetrohippocampal region21.14
13.8
Itgb5sAMYStriatum-like amygdalar nuclei16.41
13.69
Itgb5STRStriatum17.15
10.88
Itgb5STRdStriatum dorsal region15.9
9.59
Itgb5STRvStriatum ventral region19.96
10.73
Itgb5THThalamus7.96
6.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITB5_HUMAN_365 14 365 378 NIIQLIINAYNSIR PRIDE
PAp00005775 18 73 90 NGCGGEIESPASSFHVLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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