AutismKB 2.0

Annotation Detail for ITGB7


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Basic Information Top
Gene Symbol:ITGB7 ( - )
Gene Full Name: integrin, beta 7
Band: 12q13.13
Quick LinksEntrez ID:3695; OMIM: 147559; Uniprot ID:ITB7_HUMAN; ENSEMBL ID: ENSG00000139626; HGNC ID: 6162
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus1 / 5640121
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia25 / 95842260
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma11 / 71755153
non-neoplasia7 / 9725071
normal108 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood26 / 123478210
bone0 / 716550 
bone marrow8 / 48801163
brain13 / 110098911
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine7 / 23447229
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph3 / 4427067
lymph node5 / 9161054
mammary gland4 / 15327126
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta1 / 2808253
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen51 / 53952945
stomach2 / 9661920
testis3 / 3304429
thymus33 / 81131406
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205718_at
Cell line Expression level Expression bar
721_B_lymphoblasts1512.35
Adipocyte20.45
AdrenalCortex35.2
Adrenalgland14.9
Amygdala17.15
Appendix17.35
AtrioventricularNode13
BDCA4+_DentriticCells897.1
Bonemarrow26.95
BronchialEpithelialCells15.75
CD105+_Endothelial17.85
CD14+_Monocytes125.1
CD19+_BCells(neg._sel.)756.95
CD33+_Myeloid194.8
CD34+30.45
CD4+_Tcells1788.6
CD56+_NKCells2403.6
CD71+_EarlyErythroid15.95
CD8+_Tcells1501.75
CardiacMyocytes21.9
Caudatenucleus21.65
Cerebellum13.65
CerebellumPeduncles20
CiliaryGanglion12.3
CingulateCortex28.45
Colorectaladenocarcinoma16.3
DorsalRootGanglion13.3
FetalThyroid17.05
Fetalbrain16.55
Fetalliver15.05
Fetallung12.85
GlobusPallidus17.6
Heart61.8
Hypothalamus18.85
Kidney19.85
Leukemia_chronicMyelogenousK-56215.95
Leukemia_promyelocytic-HL-6032.05
Leukemialymphoblastic(MOLT-4)13.55
Liver22.85
Lung20.1
Lymphnode134.25
Lymphoma_burkitts(Daudi)105.05
Lymphoma_burkitts(Raji)355.15
MedullaOblongata15.35
OccipitalLobe15.95
OlfactoryBulb13.75
Ovary12.85
Pancreas14.05
PancreaticIslet18.6
ParietalLobe18.6
Pituitary20.1
Placenta15.55
Pons22.15
PrefrontalCortex20.1
Prostate18.8
Salivarygland18.7
SkeletalMuscle38.35
Skin13.2
SmoothMuscle19.1
Spinalcord17.75
SubthalamicNucleus22.5
SuperiorCervicalGanglion19.5
TemporalLobe16
Testis13.05
TestisGermCell14.15
TestisIntersitial14.4
TestisLeydigCell19.65
TestisSeminiferousTubule22.5
Thalamus17.95
Thymus17.65
Thyroid20.7
Tongue17.05
Tonsil28.9
Trachea18.5
TrigeminalGanglion17.05
Uterus12.05
UterusCorpus14.8
WholeBlood140.8
Wholebrain13.15
colon17.75
pineal_day21.22
pineal_night25
retina23.575
small_intestine22.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11510_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.46 ± 1.07
Basal Forebrain2.28 ± 0.6
Basal Part of Pons2.06 ± 0.66
Cerebellar Cortex1.69 ± 0.53
Cerebellar Nuclei2.31 ± 0.74
Claustrum2.67 ± 0.79
Epithalamus2.51 ± 0.69
Frontal Lobe2.02 ± 0.74
Globus Pallidus3.36 ± 0.66
Hypothalamus2.22 ± 1.17
Insula2.17 ± 0.9
Limbic Lobe2.02 ± 0.73
Mesencephalon2.26 ± 0.79
Myelencephalon2.31 ± 0.83
Occipital Lobe2.14 ± 0.72
Parietal Lobe2.15 ± 0.96
Pontine Tegmentum2.25 ± 0.8
Striatum3.27 ± 0.61
Subthalamus2.54 ± 0.25
Temporal Lobe2.1 ± 0.76
Thalamus2.2 ± 0.68
White Matter2.53 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itgb7CBCerebellum16.6
35.36
Itgb7CTXCerebral cortex29.73
23.22
Itgb7HIPHippocampal region20.9
20.61
Itgb7HPFHippocampal formation26.05
25.41
Itgb7HYHypothalamus0
0
Itgb7LSXLateral septal complex0
0
Itgb7MBMidbrain0
0
Itgb7MYMedulla23.21
36.89
Itgb7OLFOlfactory bulb23.94
24.95
Itgb7PPons0
0
Itgb7PALPallidum15.25
10.6
Itgb7RHPRetrohippocampal region33.02
30.45
Itgb7sAMYStriatum-like amygdalar nuclei11.8
9.77
Itgb7STRStriatum11.76
10.13
Itgb7STRdStriatum dorsal region11.96
10.86
Itgb7STRvStriatum ventral region3.6
2.71
Itgb7THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ITB7_HUMAN_69 10 69 78 FTASGEAEAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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