AutismKB 2.0

Annotation Detail for ITIH2


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Basic Information Top
Gene Symbol:ITIH2 ( H2P,SHAP )
Gene Full Name: inter-alpha (globulin) inhibitor H2
Band: 10p14
Quick LinksEntrez ID:3698; OMIM: 146640; Uniprot ID:ITIH2_HUMAN; ENSEMBL ID: ENSG00000151655; HGNC ID: 6167
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus71 / 564012125
neonate0 / 310970 
infant0 / 236200 
juvenile103 / 555561853
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia7 / 9584273
liver tumor122 / 963591266
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal134 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart6 / 8962666
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver171 / 207743823
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen5 / 5395292
stomach1 / 9661910
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204987_at
Cell line Expression level Expression bar
721_B_lymphoblasts24
Adipocyte35.05
AdrenalCortex32.2
Adrenalgland67.4
Amygdala33.65
Appendix36.25
AtrioventricularNode24.05
BDCA4+_DentriticCells28.65
Bonemarrow31.45
BronchialEpithelialCells21.8
CD105+_Endothelial19.4
CD14+_Monocytes21.2
CD19+_BCells(neg._sel.)22.1
CD33+_Myeloid32.05
CD34+28.65
CD4+_Tcells20.65
CD56+_NKCells38.35
CD71+_EarlyErythroid23.6
CD8+_Tcells9.6
CardiacMyocytes34.6
Caudatenucleus40.95
Cerebellum40.3
CerebellumPeduncles45.8
CiliaryGanglion22.75
CingulateCortex40.75
Colorectaladenocarcinoma27.3
DorsalRootGanglion24.15
FetalThyroid25.6
Fetalbrain31.8
Fetalliver8919.65
Fetallung174.5
GlobusPallidus23.6
Heart44.65
Hypothalamus34.8
Kidney71.3
Leukemia_chronicMyelogenousK-56228.9
Leukemia_promyelocytic-HL-6028.15
Leukemialymphoblastic(MOLT-4)26.1
Liver4290.15
Lung25.7
Lymphnode27.7
Lymphoma_burkitts(Daudi)40.8
Lymphoma_burkitts(Raji)43.85
MedullaOblongata62.7
OccipitalLobe28.8
OlfactoryBulb32.55
Ovary21.05
Pancreas25.4
PancreaticIslet31.55
ParietalLobe33.85
Pituitary53.4
Placenta30
Pons96.95
PrefrontalCortex34.5
Prostate29.2
Salivarygland33.55
SkeletalMuscle60.35
Skin24
SmoothMuscle23.05
Spinalcord34.2
SubthalamicNucleus29.1
SuperiorCervicalGanglion41.55
TemporalLobe71.8
Testis27.5
TestisGermCell26.65
TestisIntersitial28.3
TestisLeydigCell31.4
TestisSeminiferousTubule27.5
Thalamus38.1
Thymus18.8
Thyroid33.55
Tongue35.15
Tonsil30.95
Trachea26.7
TrigeminalGanglion31
Uterus23.25
UterusCorpus39.05
WholeBlood29.5
Wholebrain24.6
colon32.15
pineal_day45.62
pineal_night114.38
retina44.85
small_intestine30.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6190_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.93 ± 1.03
Basal Forebrain1.52 ± 0.59
Basal Part of Pons1.64 ± 0.69
Cerebellar Cortex1.41 ± 0.62
Cerebellar Nuclei2.14 ± 0.89
Claustrum2.22 ± 0.72
Epithalamus2.15 ± 0.75
Frontal Lobe1.44 ± 0.66
Globus Pallidus2.71 ± 0.71
Hypothalamus1.93 ± 0.83
Insula1.75 ± 0.68
Limbic Lobe1.6 ± 0.72
Mesencephalon1.78 ± 0.73
Myelencephalon1.73 ± 0.7
Occipital Lobe1.77 ± 0.68
Parietal Lobe1.52 ± 0.67
Pontine Tegmentum1.76 ± 0.83
Striatum2.29 ± 0.78
Subthalamus1.59 ± 0.72
Temporal Lobe1.62 ± 0.77
Thalamus1.73 ± 0.65
White Matter2.16 ± 0.59
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024078 25 285 309 AGELEVFNGYFVHFFAPDNLDPIPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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