Annotation Detail for ITK
Basic Information Top
| Gene Symbol: | ITK ( EMT,LYK,MGC126257,MGC126258,PSCTK2 ) |
|---|---|
| Gene Full Name: | IL2-inducible T-cell kinase |
| Band: | 5q33.3 |
| Quick Links | Entrez ID:3702; OMIM: 186973; Uniprot ID:ITK_HUMAN; ENSEMBL ID: ENSG00000113263; HGNC ID: 6171 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.558348
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 7 / 564012 | 12 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 3 / 55556 | 53 |  |
| adult | 15 / 1939121 | 7 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 5 / 95842 | 52 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 36 / 3360307 | 10 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 12 / 123478 | 97 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 2 / 1100989 | 1 |  |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 1 / 89626 | 11 | |
| intestine | 1 / 234472 | 4 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 1 / 336974 | 2 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 2 / 91610 | 21 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 1 / 280825 | 3 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 0 / 96619 | 0 | |
| testis | 2 / 330442 | 6 | |
| thymus | 32 / 81131 | 394 |  |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 5 / 232878 | 21 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 211339_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.7 | |
| Adipocyte | 6.3 | |
| AdrenalCortex | 6.85 | |
| Adrenalgland | 5.05 | |
| Amygdala | 6.4 | |
| Appendix | 6.55 | |
| AtrioventricularNode | 5.2 | |
| BDCA4+_DentriticCells | 6.05 | |
| Bonemarrow | 6.1 | |
| BronchialEpithelialCells | 5.6 | |
| CD105+_Endothelial | 5.75 | |
| CD14+_Monocytes | 5.65 | |
| CD19+_BCells(neg._sel.) | 5.8 | |
| CD33+_Myeloid | 7.2 | |
| CD34+ | 6.7 | |
| CD4+_Tcells | 977.45 | |
| CD56+_NKCells | 312.65 | |
| CD71+_EarlyErythroid | 5.25 | |
| CD8+_Tcells | 1017.75 |  |
| CardiacMyocytes | 8 | |
| Caudatenucleus | 5.3 | |
| Cerebellum | 4.8 | |
| CerebellumPeduncles | 6.85 | |
| CiliaryGanglion | 4.6 | |
| CingulateCortex | 6.1 | |
| Colorectaladenocarcinoma | 5.85 | |
| DorsalRootGanglion | 4.75 | |
| FetalThyroid | 7.6 | |
| Fetalbrain | 5.85 | |
| Fetalliver | 5.2 | |
| Fetallung | 4.65 | |
| GlobusPallidus | 4.35 | |
| Heart | 8.15 | |
| Hypothalamus | 6.25 | |
| Kidney | 4.75 | |
| Leukemia_chronicMyelogenousK-562 | 5.25 | |
| Leukemia_promyelocytic-HL-60 | 5.2 | |
| Leukemialymphoblastic(MOLT-4) | 60.5 | |
| Liver | 7.8 | |
| Lung | 6.5 | |
| Lymphnode | 27.95 | |
| Lymphoma_burkitts(Daudi) | 7.7 | |
| Lymphoma_burkitts(Raji) | 8.45 | |
| MedullaOblongata | 5.3 | |
| OccipitalLobe | 5.15 | |
| OlfactoryBulb | 4.75 | |
| Ovary | 4.15 | |
| Pancreas | 4.85 | |
| PancreaticIslet | 6.35 | |
| ParietalLobe | 6.3 | |
| Pituitary | 6.8 | |
| Placenta | 5.75 | |
| Pons | 5.7 | |
| PrefrontalCortex | 7.1 | |
| Prostate | 8 | |
| Salivarygland | 5.35 | |
| SkeletalMuscle | 7.3 | |
| Skin | 5 | |
| SmoothMuscle | 6.6 | |
| Spinalcord | 6.3 | |
| SubthalamicNucleus | 5.5 | |
| SuperiorCervicalGanglion | 7.85 | |
| TemporalLobe | 5.45 | |
| Testis | 4.95 | |
| TestisGermCell | 4.8 | |
| TestisIntersitial | 4.95 | |
| TestisLeydigCell | 5.95 | |
| TestisSeminiferousTubule | 5.05 | |
| Thalamus | 6 | |
| Thymus | 128.1 | |
| Thyroid | 7.3 | |
| Tongue | 6 | |
| Tonsil | 13.55 | |
| Trachea | 4.8 | |
| TrigeminalGanglion | 10.05 | |
| Uterus | 4.65 | |
| UterusCorpus | 5.4 | |
| WholeBlood | 80.9 | |
| Wholebrain | 4.9 | |
| colon | 5.95 | |
| pineal_day | 7.08 | |
| pineal_night | 7 | |
| retina | 7.325 | |
| small_intestine | 5.6 | |
- Probe name: A_23_P354151
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.34 ± 1.06 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 1.85 ± 0.22 | |
| Basal Part of Pons | 1.48 ± 0.53 | |
| Cerebellar Cortex | 1.71 ± 0.85 | |
| Cerebellar Nuclei | 2.31 ± 0.71 | |
| Claustrum | 2.72 ± 0.82 | |
| Epithalamus | 1.5 ± 0.76 | |
| Frontal Lobe | 1.68 ± 0.67 | |
| Globus Pallidus | 2.61 ± 0.56 | |
| Hypothalamus | 1.96 ± 0.69 | |
| Insula | 1.9 ± 1.22 | |
| Limbic Lobe | 1.89 ± 0.83 | |
| Mesencephalon | 2.03 ± 0.79 | |
| Myelencephalon | 1.88 ± 0.71 | |
| Occipital Lobe | 1.91 ± 0.73 | |
| Parietal Lobe | 1.88 ± 0.79 | |
| Pontine Tegmentum | 2.04 ± 0.75 | |
| Striatum | 2.11 ± 0.63 | |
| Subthalamus | 2.01 ± 0.75 | |
| Temporal Lobe | 1.82 ± 0.75 | |
| Thalamus | 1.79 ± 0.63 | |
| White Matter | 2.24 ± 0.26 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Itk | CB | Cerebellum | 2.58 | |
| 3.67 | | |||
| Itk | CTX | Cerebral cortex | 1.98 | |
| 2.55 | | |||
| Itk | HIP | Hippocampal region | 1.14 | |
| 1.28 | | |||
| Itk | HPF | Hippocampal formation | 0.91 | |
| 1.15 | | |||
| Itk | HY | Hypothalamus | 0.06 | |
| 0.04 | | |||
| Itk | LSX | Lateral septal complex | 0 | |
| 0 | | |||
| Itk | MB | Midbrain | 0.4 | |
| 0.63 | | |||
| Itk | MY | Medulla | 4.01 | |
| 5.21 | | |||
| Itk | OLF | Olfactory bulb | 0.59 | |
| 0.42 | | |||
| Itk | P | Pons | 0.39 | |
| 0.59 | | |||
| Itk | PAL | Pallidum | 0.46 | |
| 1.41 | | |||
| Itk | RHP | Retrohippocampal region | 0.6 | |
| 1 | | |||
| Itk | sAMY | Striatum-like amygdalar nuclei | 0.28 | |
| 0.24 | | |||
| Itk | STR | Striatum | 0.87 | |
| 1.29 | | |||
| Itk | STRd | Striatum dorsal region | 0.94 | |
| 1.64 | | |||
| Itk | STRv | Striatum ventral region | 1.35 | |
| 1.32 | | |||
| Itk | TH | Thalamus | 2.98 | |
| 4.02 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| ITK_HUMAN_611 | 10 | 611 | 620 | QLAEIAESGL | PRIDE |
| PAp00043384 | 23 | 311 | 333 | YVFDSIPLLINYHQHNGGGLVTR | Peptide Atlas |