AutismKB 2.0

Annotation Detail for KCNA4


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Basic Information Top
Gene Symbol:KCNA4 ( HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Band: 11p14.1
Quick LinksEntrez ID:3739; OMIM: 176266; Uniprot ID:KCNA4_HUMAN; ENSEMBL ID: ENSG00000182255; HGNC ID: 6222
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal22 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain20 / 110098918
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung13 / 33697438
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207248_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.65
Adipocyte7.8
AdrenalCortex8.6
Adrenalgland6.7
Amygdala8.3
Appendix8.65
AtrioventricularNode7.15
BDCA4+_DentriticCells7.85
Bonemarrow8
BronchialEpithelialCells7.3
CD105+_Endothelial7.7
CD14+_Monocytes8.25
CD19+_BCells(neg._sel.)8.25
CD33+_Myeloid9.8
CD34+9
CD4+_Tcells8.4
CD56+_NKCells8.9
CD71+_EarlyErythroid7.65
CD8+_Tcells7.3
CardiacMyocytes10.8
Caudatenucleus7.1
Cerebellum6.4
CerebellumPeduncles9
CiliaryGanglion7.95
CingulateCortex8.1
Colorectaladenocarcinoma7.8
DorsalRootGanglion6.65
FetalThyroid7.7
Fetalbrain7.7
Fetalliver7.2
Fetallung6.6
GlobusPallidus5.95
Heart13
Hypothalamus7.95
Kidney6.55
Leukemia_chronicMyelogenousK-5627.15
Leukemia_promyelocytic-HL-607
Leukemialymphoblastic(MOLT-4)6.35
Liver12.75
Lung8.5
Lymphnode6.65
Lymphoma_burkitts(Daudi)10.1
Lymphoma_burkitts(Raji)12.35
MedullaOblongata7.05
OccipitalLobe7.15
OlfactoryBulb6.1
Ovary6.55
Pancreas6.4
PancreaticIslet8.45
ParietalLobe8.4
Pituitary9.65
Placenta7.85
Pons7.75
PrefrontalCortex9.2
Prostate9.05
Salivarygland6.35
SkeletalMuscle11
Skin7.15
SmoothMuscle8.9
Spinalcord8.45
SubthalamicNucleus7.45
SuperiorCervicalGanglion13.65
TemporalLobe7.2
Testis6.65
TestisGermCell6.3
TestisIntersitial6.9
TestisLeydigCell8.1
TestisSeminiferousTubule6.8
Thalamus8.05
Thymus6.1
Thyroid9.65
Tongue9.25
Tonsil7.7
Trachea6.55
TrigeminalGanglion10.05
Uterus6.45
UterusCorpus7.15
WholeBlood8.3
Wholebrain6.65
colon7.95
pineal_day9.94
pineal_night9.82
retina9.475
small_intestine7.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16927_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.18 ± 0.73
Basal Forebrain3.72 ± 0.53
Basal Part of Pons5.02 ± 0.72
Cerebellar Cortex3.46 ± 0.48
Cerebellar Nuclei3.9 ± 0.49
Claustrum3.95 ± 0.76
Epithalamus3.8 ± 0.85
Frontal Lobe4.1 ± 0.79
Globus Pallidus3.17 ± 1.22
Hypothalamus4.17 ± 1.01
Insula4.67 ± 0.56
Limbic Lobe4.13 ± 0.87
Mesencephalon4.03 ± 0.77
Myelencephalon4.13 ± 0.72
Occipital Lobe4.03 ± 0.85
Parietal Lobe4.2 ± 0.8
Pontine Tegmentum4.11 ± 0.76
Striatum4.96 ± 0.75
Subthalamus3.75 ± 0.92
Temporal Lobe4.51 ± 0.57
Thalamus4.42 ± 0.73
White Matter2.55 ± 1.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcna4STRdStriatum dorsal region81.28
64.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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