AutismKB 2.0

Annotation Detail for AREG


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Basic Information Top
Gene Symbol:AREG ( AR,AREGB,CRDGF,MGC13647,SDGF )
Gene Full Name: amphiregulin
Band: 4q13.3
Quick LinksEntrez ID:374; OMIM: 104640; Uniprot ID:AREG_HUMAN; ENSEMBL ID: ENSG00000109321; HGNC ID: 651
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor3 / 17290173
gastrointestinal tumor9 / 11936975
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal30 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow2 / 4880140
brain1 / 11009890 
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus3 / 20209148
eye0 / 2110540 
heart0 / 896260 
intestine7 / 23447229
kidney0 / 2117770 
larynx0 / 241450 
liver11 / 20774352
lung7 / 33697420
lymph0 / 442700 
lymph node2 / 9161021
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate3 / 18934515
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach10 / 96619103
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205239_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte7.6
AdrenalCortex10.2
Adrenalgland7.2
Amygdala7.95
Appendix10.75
AtrioventricularNode9.9
BDCA4+_DentriticCells10.55
Bonemarrow9.2
BronchialEpithelialCells1645.25
CD105+_Endothelial7.85
CD14+_Monocytes8.55
CD19+_BCells(neg._sel.)9.75
CD33+_Myeloid15.25
CD34+24.95
CD4+_Tcells7.85
CD56+_NKCells68.55
CD71+_EarlyErythroid7.7
CD8+_Tcells7.35
CardiacMyocytes13.3
Caudatenucleus7.2
Cerebellum6.55
CerebellumPeduncles9.85
CiliaryGanglion6.95
CingulateCortex8.35
Colorectaladenocarcinoma8.15
DorsalRootGanglion7.75
FetalThyroid8.05
Fetalbrain7.65
Fetalliver7.05
Fetallung8.2
GlobusPallidus6.3
Heart11.9
Hypothalamus8.3
Kidney7.05
Leukemia_chronicMyelogenousK-56211.65
Leukemia_promyelocytic-HL-606.9
Leukemialymphoblastic(MOLT-4)6
Liver11.55
Lung16.65
Lymphnode6.35
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)12.4
MedullaOblongata6.85
OccipitalLobe7
OlfactoryBulb6.25
Ovary6.4
Pancreas38.15
PancreaticIslet8.75
ParietalLobe8.95
Pituitary9.15
Placenta250.2
Pons7.85
PrefrontalCortex9.2
Prostate9.25
Salivarygland7.05
SkeletalMuscle13.5
Skin7.5
SmoothMuscle8.85
Spinalcord8.4
SubthalamicNucleus8.45
SuperiorCervicalGanglion14.1
TemporalLobe7.65
Testis8.05
TestisGermCell6.45
TestisIntersitial7.7
TestisLeydigCell9.45
TestisSeminiferousTubule6.8
Thalamus8.25
Thymus5.8
Thyroid9.2
Tongue9.5
Tonsil7.9
Trachea6.6
TrigeminalGanglion11.2
Uterus6.4
UterusCorpus8.3
WholeBlood8.4
Wholebrain6
colon19.45
pineal_day9.5
pineal_night9.28
retina9.75
small_intestine7.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2894_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.4 ± 1.18
Basal Forebrain2.82 ± 0.3
Basal Part of Pons2.52 ± 0.41
Cerebellar Cortex2.44 ± 0.72
Cerebellar Nuclei3.01 ± 0.54
Claustrum3.77 ± 0.68
Epithalamus3.09 ± 0.93
Frontal Lobe2.96 ± 0.89
Globus Pallidus2.3 ± 0.82
Hypothalamus2.85 ± 0.72
Insula3 ± 0.56
Limbic Lobe2.94 ± 0.77
Mesencephalon3.02 ± 0.85
Myelencephalon2.9 ± 0.83
Occipital Lobe3.89 ± 0.69
Parietal Lobe2.72 ± 0.82
Pontine Tegmentum2.97 ± 0.84
Striatum2.15 ± 1.07
Subthalamus2.91 ± 0.91
Temporal Lobe3.23 ± 0.83
Thalamus2.57 ± 0.71
White Matter1.85 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AregCBCerebellum12.01
18.58
AregCTXCerebral cortex42.87
32.95
AregHIPHippocampal region19.1
19.87
AregHPFHippocampal formation23.89
23.05
AregHYHypothalamus22.58
19.58
AregLSXLateral septal complex9.9
9.26
AregMBMidbrain20.78
22.35
AregMYMedulla16.94
20.05
AregOLFOlfactory bulb34.65
29.79
AregPPons20.53
23.47
AregPALPallidum23.41
20.41
AregRHPRetrohippocampal region33
28.47
AregsAMYStriatum-like amygdalar nuclei11.31
8.09
AregSTRStriatum24.82
18.77
AregSTRdStriatum dorsal region29.35
22.82
AregSTRvStriatum ventral region28.17
18.66
AregTHThalamus26.97
25.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00012084 11 161 171 YIEHLEAVTCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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