AutismKB 2.0

Annotation Detail for NHLRC2


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Basic Information Top
Gene Symbol:NHLRC2 ( DKFZp779F115,FLJ20147,FLJ25621,FLJ33312,MGC45492 )
Gene Full Name: NHL repeat containing 2
Band: 10q25.3
Quick LinksEntrez ID:374354; OMIM: NA; Uniprot ID:NHLC2_HUMAN; ENSEMBL ID: ENSG00000196865; HGNC ID: 24731
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus18 / 56401231
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult30 / 193912115
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal60 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal75 / 336030722
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow2 / 4880140
brain10 / 11009899
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye2 / 2110549
heart3 / 8962633
intestine3 / 23447212
kidney5 / 21177723
larynx1 / 2414541
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node8 / 9161087
mammary gland4 / 15327126
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach4 / 9661941
testis6 / 33044218
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain19 / 110098917
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver2 / 2077439
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta19 / 28082567
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach1 / 9661910
testis2 / 3304426
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219353_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.85
Adipocyte6.75
AdrenalCortex9.6
Adrenalgland6.7
Amygdala8.35
Appendix9.1
AtrioventricularNode7.65
BDCA4+_DentriticCells7.65
Bonemarrow8.05
BronchialEpithelialCells6.85
CD105+_Endothelial7.7
CD14+_Monocytes7.95
CD19+_BCells(neg._sel.)9.55
CD33+_Myeloid9.25
CD34+10.25
CD4+_Tcells7.8
CD56+_NKCells7.85
CD71+_EarlyErythroid7.1
CD8+_Tcells7.45
CardiacMyocytes17.05
Caudatenucleus6.9
Cerebellum6
CerebellumPeduncles8.95
CiliaryGanglion6.75
CingulateCortex7.95
Colorectaladenocarcinoma7.7
DorsalRootGanglion8.05
FetalThyroid7.6
Fetalbrain7.4
Fetalliver6.5
Fetallung6.4
GlobusPallidus6.2
Heart10.85
Hypothalamus8.65
Kidney6.75
Leukemia_chronicMyelogenousK-5629.3
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)5.55
Liver11.05
Lung7.7
Lymphnode6.45
Lymphoma_burkitts(Daudi)10.1
Lymphoma_burkitts(Raji)12.5
MedullaOblongata6.6
OccipitalLobe6.5
OlfactoryBulb6.05
Ovary6.25
Pancreas6.4
PancreaticIslet9.35
ParietalLobe8.35
Pituitary9.15
Placenta7.05
Pons7.35
PrefrontalCortex11.9
Prostate10.55
Salivarygland6.5
SkeletalMuscle10.8
Skin7.65
SmoothMuscle8.3
Spinalcord8.25
SubthalamicNucleus7.15
SuperiorCervicalGanglion12.3
TemporalLobe6.95
Testis6.3
TestisGermCell6.55
TestisIntersitial6.45
TestisLeydigCell7.8
TestisSeminiferousTubule6.35
Thalamus7.6
Thymus5.75
Thyroid18.8
Tongue8.25
Tonsil7.45
Trachea6.8
TrigeminalGanglion10.25
Uterus15.75
UterusCorpus8.3
WholeBlood7.7
Wholebrain6.1
colon8.35
pineal_day112.62
pineal_night112.92
retina24.125
small_intestine10.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2027_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.38 ± 0.37
Basal Forebrain7.55 ± 0.21
Basal Part of Pons7.02 ± 0.18
Cerebellar Cortex7.5 ± 0.24
Cerebellar Nuclei7.44 ± 0.24
Claustrum7.24 ± 0.3
Epithalamus7.95 ± 0.29
Frontal Lobe7.19 ± 0.31
Globus Pallidus7.86 ± 0.21
Hypothalamus7.54 ± 0.37
Insula7.29 ± 0.32
Limbic Lobe7.15 ± 0.35
Mesencephalon7.45 ± 0.26
Myelencephalon7.33 ± 0.35
Occipital Lobe7.65 ± 0.28
Parietal Lobe7.38 ± 0.3
Pontine Tegmentum7.37 ± 0.35
Striatum7.32 ± 0.35
Subthalamus7.34 ± 0.29
Temporal Lobe7.23 ± 0.3
Thalamus7.32 ± 0.24
White Matter8.15 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nhlrc2CBCerebellum2.4
2.67
Nhlrc2CTXCerebral cortex4.22
2.82
Nhlrc2HIPHippocampal region4.16
3.83
Nhlrc2HPFHippocampal formation3.33
2.8
Nhlrc2HYHypothalamus0.56
0.49
Nhlrc2LSXLateral septal complex0.51
0.38
Nhlrc2MBMidbrain1.3
1.32
Nhlrc2MYMedulla2.28
3.17
Nhlrc2OLFOlfactory bulb4.49
4.51
Nhlrc2PPons1.33
1.31
Nhlrc2PALPallidum0.84
0.97
Nhlrc2RHPRetrohippocampal region2.27
1.62
Nhlrc2sAMYStriatum-like amygdalar nuclei0.74
0.67
Nhlrc2STRStriatum0.64
0.51
Nhlrc2STRdStriatum dorsal region0.47
0.42
Nhlrc2STRvStriatum ventral region1.2
0.77
Nhlrc2THThalamus2.3
3
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00077776 25 10 34 SLSGLLPAQTSLEYALLDAVTQQEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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