AutismKB 2.0

Annotation Detail for KCNC1


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Basic Information Top
Gene Symbol:KCNC1 ( FLJ41162,FLJ42249,FLJ43491,KV3.1,KV4,MGC129855,NGK2 )
Gene Full Name: potassium voltage-gated channel, Shaw-related subfamily, member 1
Band: 11p15.1
Quick LinksEntrez ID:3746; OMIM: 176258; Uniprot ID:KCNC1_HUMAN; ENSEMBL ID: ENSG00000129159; HGNC ID: 6233
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal54 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye11 / 21105452
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208477_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.3
Adipocyte11.25
AdrenalCortex25.85
Adrenalgland15.15
Amygdala38.65
Appendix34.4
AtrioventricularNode8.45
BDCA4+_DentriticCells9.55
Bonemarrow14.05
BronchialEpithelialCells10.75
CD105+_Endothelial9.15
CD14+_Monocytes10
CD19+_BCells(neg._sel.)9.5
CD33+_Myeloid9.6
CD34+12.1
CD4+_Tcells8.4
CD56+_NKCells9.7
CD71+_EarlyErythroid8.9
CD8+_Tcells8.45
CardiacMyocytes14.1
Caudatenucleus17.4
Cerebellum113.95
CerebellumPeduncles94.95
CiliaryGanglion7.3
CingulateCortex40.85
Colorectaladenocarcinoma9.45
DorsalRootGanglion12.05
FetalThyroid12
Fetalbrain15
Fetalliver9.1
Fetallung8.1
GlobusPallidus18.35
Heart26.45
Hypothalamus28.4
Kidney10.55
Leukemia_chronicMyelogenousK-56211.55
Leukemia_promyelocytic-HL-608.65
Leukemialymphoblastic(MOLT-4)7.95
Liver16.25
Lung10.9
Lymphnode9.45
Lymphoma_burkitts(Daudi)17.45
Lymphoma_burkitts(Raji)15.4
MedullaOblongata58.15
OccipitalLobe28.8
OlfactoryBulb7.6
Ovary7.35
Pancreas9.95
PancreaticIslet12.15
ParietalLobe65.25
Pituitary19.2
Placenta9.5
Pons39.5
PrefrontalCortex23.95
Prostate10.75
Salivarygland8
SkeletalMuscle40.4
Skin9.95
SmoothMuscle10.65
Spinalcord12.15
SubthalamicNucleus49.25
SuperiorCervicalGanglion12.3
TemporalLobe56.9
Testis18.2
TestisGermCell11.9
TestisIntersitial14.95
TestisLeydigCell10.3
TestisSeminiferousTubule11.85
Thalamus28.7
Thymus7.95
Thyroid12.25
Tongue10.5
Tonsil17.85
Trachea8.3
TrigeminalGanglion10.4
Uterus7.65
UterusCorpus14.35
WholeBlood10.5
Wholebrain41.5
colon9.45
pineal_day11.78
pineal_night11
retina12.475
small_intestine9.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6037_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.07 ± 0.76
Basal Forebrain4.64 ± 1
Basal Part of Pons6.42 ± 0.25
Cerebellar Cortex6.22 ± 0.43
Cerebellar Nuclei5.53 ± 0.76
Claustrum4.91 ± 0.81
Epithalamus4.22 ± 1.05
Frontal Lobe5.61 ± 0.69
Globus Pallidus4.54 ± 0.51
Hypothalamus5.05 ± 0.84
Insula5.5 ± 0.34
Limbic Lobe5.14 ± 0.76
Mesencephalon5.16 ± 0.71
Myelencephalon5.36 ± 0.89
Occipital Lobe5.26 ± 0.64
Parietal Lobe5.64 ± 0.83
Pontine Tegmentum5.17 ± 0.7
Striatum4.16 ± 0.57
Subthalamus5.9 ± 0.47
Temporal Lobe5.5 ± 0.56
Thalamus5.6 ± 0.62
White Matter2.9 ± 0.79
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnc1CBCerebellum100
100
Kcnc1CTXCerebral cortex69.54
78.93
Kcnc1HIPHippocampal region65.08
91.12
Kcnc1HPFHippocampal formation60.53
85.23
Kcnc1HYHypothalamus58.55
64.65
Kcnc1LSXLateral septal complex13.49
11.76
Kcnc1MBMidbrain93.63
100
Kcnc1MYMedulla85.32
100
Kcnc1OLFOlfactory bulb67.26
84.04
Kcnc1PPons79.49
100
Kcnc1PALPallidum61.84
87.86
Kcnc1RHPRetrohippocampal region56.2
66.68
Kcnc1sAMYStriatum-like amygdalar nuclei52.32
49.4
Kcnc1STRStriatum20.77
21.76
Kcnc1STRdStriatum dorsal region15.42
17.18
Kcnc1STRvStriatum ventral region24.25
24.57
Kcnc1THThalamus96.14
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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