AutismKB 2.0

Annotation Detail for KCND2


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Basic Information Top
Gene Symbol:KCND2 ( KIAA1044,KV4.2,MGC119702,MGC119703,RK5 )
Gene Full Name: potassium voltage-gated channel, Shal-related subfamily, member 2
Band: 7q31.31
Quick LinksEntrez ID:3751; OMIM: 605410; Uniprot ID:KCND2_HUMAN; ENSEMBL ID: ENSG00000184408; HGNC ID: 6238
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal43 / 336030712
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain43 / 110098939
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207103_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte7.05
AdrenalCortex9.4
Adrenalgland6.65
Amygdala7.9
Appendix9.85
AtrioventricularNode7.45
BDCA4+_DentriticCells6.95
Bonemarrow8.1
BronchialEpithelialCells6.85
CD105+_Endothelial7.05
CD14+_Monocytes7.75
CD19+_BCells(neg._sel.)7.35
CD33+_Myeloid8.7
CD34+8.45
CD4+_Tcells7.2
CD56+_NKCells7.9
CD71+_EarlyErythroid6.95
CD8+_Tcells6.35
CardiacMyocytes11.35
Caudatenucleus8.3
Cerebellum21.05
CerebellumPeduncles58.2
CiliaryGanglion7.8
CingulateCortex9.4
Colorectaladenocarcinoma7.15
DorsalRootGanglion7.1
FetalThyroid7.25
Fetalbrain12.45
Fetalliver6.5
Fetallung5.45
GlobusPallidus5.85
Heart11.15
Hypothalamus10.75
Kidney6.75
Leukemia_chronicMyelogenousK-5626.45
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.6
Liver10.9
Lung7.75
Lymphnode5.9
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)10.95
MedullaOblongata6.6
OccipitalLobe6.55
OlfactoryBulb5.65
Ovary5.8
Pancreas6.15
PancreaticIslet7.85
ParietalLobe8.4
Pituitary8.65
Placenta7.05
Pons7.35
PrefrontalCortex13.65
Prostate8.15
Salivarygland6.2
SkeletalMuscle11.25
Skin8.6
SmoothMuscle8.1
Spinalcord7.7
SubthalamicNucleus7.55
SuperiorCervicalGanglion16.65
TemporalLobe8.65
Testis6.15
TestisGermCell5.7
TestisIntersitial6.3
TestisLeydigCell7.65
TestisSeminiferousTubule6.2
Thalamus8.55
Thymus5.35
Thyroid8.5
Tongue8.45
Tonsil7.2
Trachea5.95
TrigeminalGanglion11.15
Uterus5.65
UterusCorpus8.25
WholeBlood7.7
Wholebrain6.2
colon7.2
pineal_day8.82
pineal_night8.66
retina8.75
small_intestine6.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P112564
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.92 ± 0.29
Basal Forebrain8 ± 0.27
Basal Part of Pons9.54 ± 0.21
Cerebellar Cortex9.03 ± 0.22
Cerebellar Nuclei8.34 ± 0.4
Claustrum8.62 ± 0.85
Epithalamus7.35 ± 1.26
Frontal Lobe8.3 ± 0.48
Globus Pallidus7.87 ± 0.42
Hypothalamus8.15 ± 0.33
Insula8.44 ± 0.39
Limbic Lobe8.27 ± 0.42
Mesencephalon8.28 ± 0.53
Myelencephalon8.4 ± 0.7
Occipital Lobe8.46 ± 0.54
Parietal Lobe8.37 ± 0.47
Pontine Tegmentum8.2 ± 0.45
Striatum9.17 ± 0.89
Subthalamus8.81 ± 0.12
Temporal Lobe8.29 ± 0.39
Thalamus9.16 ± 0.55
White Matter5.76 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnd2CBCerebellum35.03
44.67
Kcnd2CTXCerebral cortex12.32
9.7
Kcnd2HIPHippocampal region25.34
43.57
Kcnd2HPFHippocampal formation19.39
27.47
Kcnd2HYHypothalamus1.49
1.45
Kcnd2LSXLateral septal complex1.72
1.74
Kcnd2MBMidbrain6.24
6.71
Kcnd2MYMedulla8.61
10.22
Kcnd2OLFOlfactory bulb24.63
25.94
Kcnd2PPons7.25
8.48
Kcnd2PALPallidum2.71
2.52
Kcnd2RHPRetrohippocampal region11.33
9.21
Kcnd2sAMYStriatum-like amygdalar nuclei1.04
0.98
Kcnd2STRStriatum20.2
15.51
Kcnd2STRdStriatum dorsal region25.19
19.32
Kcnd2STRvStriatum ventral region22.07
16.51
Kcnd2THThalamus6.72
6.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KCND2_HUMAN_423 7 423 429 RAQKKAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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