AutismKB 2.0

Annotation Detail for KCNJ4


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Basic Information Top
Gene Symbol:KCNJ4 ( HIR,HIRK2,HRK1,IRK-3,IRK3,Kir2.3,MGC142066,MGC142068 )
Gene Full Name: potassium inwardly-rectifying channel, subfamily J, member 4
Band: 22q13.1
Quick LinksEntrez ID:3761; OMIM: 600504; Uniprot ID:IRK4_HUMAN; ENSEMBL ID: ENSG00000168135; HGNC ID: 6265
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult3 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal9 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain11 / 11009899
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211451_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7
Adipocyte5.55
AdrenalCortex5.95
Adrenalgland4.75
Amygdala11.25
Appendix5.65
AtrioventricularNode4.85
BDCA4+_DentriticCells6.1
Bonemarrow5.9
BronchialEpithelialCells5.5
CD105+_Endothelial5.7
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)6
CD33+_Myeloid7.05
CD34+7.15
CD4+_Tcells6.1
CD56+_NKCells6.65
CD71+_EarlyErythroid10.6
CD8+_Tcells5.4
CardiacMyocytes7.3
Caudatenucleus5.1
Cerebellum4.5
CerebellumPeduncles6.55
CiliaryGanglion4.65
CingulateCortex5.75
Colorectaladenocarcinoma5.55
DorsalRootGanglion4.65
FetalThyroid5.45
Fetalbrain5.55
Fetalliver4.85
Fetallung4.45
GlobusPallidus4.45
Heart8.05
Hypothalamus6.05
Kidney4.55
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)4.35
Liver7.75
Lung6.15
Lymphnode4.75
Lymphoma_burkitts(Daudi)7.3
Lymphoma_burkitts(Raji)8
MedullaOblongata5.1
OccipitalLobe5.05
OlfactoryBulb4.4
Ovary3.75
Pancreas4.65
PancreaticIslet5.95
ParietalLobe6.1
Pituitary6.5
Placenta5.75
Pons5.4
PrefrontalCortex6.8
Prostate6.45
Salivarygland4.5
SkeletalMuscle7.3
Skin4.35
SmoothMuscle6.3
Spinalcord5.95
SubthalamicNucleus5.5
SuperiorCervicalGanglion6.35
TemporalLobe5.1
Testis4.75
TestisGermCell4.55
TestisIntersitial4.7
TestisLeydigCell5.55
TestisSeminiferousTubule4.75
Thalamus5.7
Thymus4.25
Thyroid7
Tongue5.7
Tonsil5.45
Trachea4.65
TrigeminalGanglion5.6
Uterus4.55
UterusCorpus5.25
WholeBlood6.05
Wholebrain7.85
colon5.6
pineal_day7
pineal_night6.86
retina6.75
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P6125
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.06 ± 0.9
Basal Forebrain3.69 ± 0.67
Basal Part of Pons3.3 ± 0.55
Cerebellar Cortex2.88 ± 0.44
Cerebellar Nuclei3.36 ± 0.6
Claustrum3.11 ± 1.05
Epithalamus3.62 ± 1.06
Frontal Lobe4.25 ± 0.98
Globus Pallidus2 ± 1.33
Hypothalamus3.54 ± 0.97
Insula4.14 ± 0.74
Limbic Lobe4.03 ± 1.06
Mesencephalon3.78 ± 0.97
Myelencephalon3.7 ± 0.78
Occipital Lobe3.11 ± 1.23
Parietal Lobe4 ± 0.86
Pontine Tegmentum3.93 ± 1.01
Striatum4.03 ± 1.17
Subthalamus3.57 ± 0.81
Temporal Lobe4.27 ± 0.78
Thalamus3.31 ± 0.96
White Matter1.61 ± 1.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnj4CBCerebellum24.23
35.26
Kcnj4CTXCerebral cortex100
100
Kcnj4HIPHippocampal region75.88
100
Kcnj4HPFHippocampal formation84.8
100
Kcnj4HYHypothalamus8.77
6.99
Kcnj4LSXLateral septal complex33.96
32.14
Kcnj4MBMidbrain9.03
9.16
Kcnj4MYMedulla15.52
18.22
Kcnj4OLFOlfactory bulb100
100
Kcnj4PPons5.34
5.78
Kcnj4PALPallidum19.43
20.67
Kcnj4RHPRetrohippocampal region100
100
Kcnj4sAMYStriatum-like amygdalar nuclei40.36
36.96
Kcnj4STRStriatum100
100
Kcnj4STRdStriatum dorsal region100
100
Kcnj4STRvStriatum ventral region100
100
Kcnj4THThalamus19.87
19.91
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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