AutismKB 2.0

Annotation Detail for KCNN3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCNN3 ( KCa2.3,SK3,SKCA3,hSK3 )
Gene Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Band: 1q21.3
Quick LinksEntrez ID:3782; OMIM: 602983; Uniprot ID:KCNN3_HUMAN; ENSEMBL ID: ENSG00000143603; HGNC ID: 6292
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult15 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal31 / 33603079
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph4 / 4427090
lymph node12 / 91610130
mammary gland0 / 1532710 
mouth5 / 6705274
muscle9 / 10771583
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205902_at
Cell line Expression level Expression bar
721_B_lymphoblasts21.1
Adipocyte5.65
AdrenalCortex6.1
Adrenalgland4.85
Amygdala8.4
Appendix7.75
AtrioventricularNode5
BDCA4+_DentriticCells5.65
Bonemarrow5.7
BronchialEpithelialCells5.6
CD105+_Endothelial5.5
CD14+_Monocytes6.05
CD19+_BCells(neg._sel.)5.85
CD33+_Myeloid6.95
CD34+6.45
CD4+_Tcells5.85
CD56+_NKCells6.35
CD71+_EarlyErythroid5.4
CD8+_Tcells4.95
CardiacMyocytes7.1
Caudatenucleus5.15
Cerebellum4.65
CerebellumPeduncles6.9
CiliaryGanglion4.55
CingulateCortex8.7
Colorectaladenocarcinoma5.7
DorsalRootGanglion4.7
FetalThyroid5.6
Fetalbrain5.75
Fetalliver4.9
Fetallung4.5
GlobusPallidus4.95
Heart7.15
Hypothalamus6.2
Kidney4.9
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-6019.2
Leukemialymphoblastic(MOLT-4)4.65
Liver7.55
Lung6.35
Lymphnode4.95
Lymphoma_burkitts(Daudi)8.15
Lymphoma_burkitts(Raji)69.7
MedullaOblongata5.3
OccipitalLobe5.9
OlfactoryBulb4.5
Ovary3.8
Pancreas4.7
PancreaticIslet6.1
ParietalLobe6.15
Pituitary6.75
Placenta5.5
Pons5.65
PrefrontalCortex10.25
Prostate6.75
Salivarygland4.75
SkeletalMuscle7.5
Skin4.45
SmoothMuscle6.55
Spinalcord6.15
SubthalamicNucleus5.95
SuperiorCervicalGanglion6.55
TemporalLobe5.35
Testis4.9
TestisGermCell4.55
TestisIntersitial4.75
TestisLeydigCell5.7
TestisSeminiferousTubule4.9
Thalamus5.9
Thymus4.3
Thyroid6.9
Tongue5.9
Tonsil5.55
Trachea4.8
TrigeminalGanglion6.6
Uterus30.95
UterusCorpus5.35
WholeBlood5.7
Wholebrain4.95
colon5.75
pineal_day7.12
pineal_night6.92
retina12.375
small_intestine5.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15115_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.29 ± 0.57
Basal Forebrain4.75 ± 0.23
Basal Part of Pons2.99 ± 0.44
Cerebellar Cortex3.51 ± 0.48
Cerebellar Nuclei3.86 ± 1.11
Claustrum3.85 ± 0.89
Epithalamus4.72 ± 0.6
Frontal Lobe3.89 ± 0.74
Globus Pallidus5.91 ± 0.42
Hypothalamus4.33 ± 0.48
Insula3.9 ± 0.54
Limbic Lobe3.94 ± 0.82
Mesencephalon4.66 ± 0.76
Myelencephalon4.29 ± 0.77
Occipital Lobe3.81 ± 0.65
Parietal Lobe4.06 ± 0.78
Pontine Tegmentum4.22 ± 0.48
Striatum5.38 ± 0.49
Subthalamus2.76 ± 0.97
Temporal Lobe4.21 ± 0.59
Thalamus4.69 ± 0.52
White Matter3.83 ± 0.45
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018