AutismKB 2.0

Annotation Detail for KDR


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Basic Information Top
Gene Symbol:KDR ( CD309,FLK1,VEGFR,VEGFR2 )
Gene Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Band: 4q12
Quick LinksEntrez ID:3791; OMIM: 191306; Uniprot ID:VGFR2_HUMAN; ENSEMBL ID: ENSG00000128052; HGNC ID: 6307
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus40 / 56401270
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult66 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal140 / 336030741
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain17 / 110098915
cervix0 / 481710 
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye16 / 21105475
heart5 / 8962655
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta17 / 28082560
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus9 / 23287838
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203934_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.4
Adipocyte8.2
AdrenalCortex9.55
Adrenalgland8.05
Amygdala8.5
Appendix11.2
AtrioventricularNode7.15
BDCA4+_DentriticCells8
Bonemarrow9.9
BronchialEpithelialCells8.2
CD105+_Endothelial15.45
CD14+_Monocytes9
CD19+_BCells(neg._sel.)8.9
CD33+_Myeloid10.15
CD34+11.05
CD4+_Tcells9.4
CD56+_NKCells9.85
CD71+_EarlyErythroid8.2
CD8+_Tcells7.95
CardiacMyocytes24.7
Caudatenucleus7.7
Cerebellum6.95
CerebellumPeduncles10
CiliaryGanglion7
CingulateCortex9.05
Colorectaladenocarcinoma8.45
DorsalRootGanglion7.15
FetalThyroid22.15
Fetalbrain8.6
Fetalliver22.55
Fetallung39.8
GlobusPallidus6.55
Heart15.3
Hypothalamus8.6
Kidney9.9
Leukemia_chronicMyelogenousK-5627.75
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)6.9
Liver13.35
Lung29.35
Lymphnode8.95
Lymphoma_burkitts(Daudi)11.45
Lymphoma_burkitts(Raji)13.65
MedullaOblongata7.65
OccipitalLobe7.55
OlfactoryBulb6.75
Ovary6.5
Pancreas7
PancreaticIslet9.3
ParietalLobe9.1
Pituitary10
Placenta72.45
Pons8.6
PrefrontalCortex10.6
Prostate10.25
Salivarygland7.25
SkeletalMuscle10.15
Skin8
SmoothMuscle10.95
Spinalcord10.7
SubthalamicNucleus8
SuperiorCervicalGanglion12.3
TemporalLobe8.3
Testis7.4
TestisGermCell7.3
TestisIntersitial7.2
TestisLeydigCell9.05
TestisSeminiferousTubule7.4
Thalamus8.8
Thymus6.45
Thyroid93.6
Tongue9.25
Tonsil8.4
Trachea8.7
TrigeminalGanglion10.7
Uterus40.6
UterusCorpus10.35
WholeBlood9.2
Wholebrain7.1
colon9.4
pineal_day15.18
pineal_night18.02
retina87.15
small_intestine50.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P58419
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.41 ± 0.8
Basal Forebrain4.53 ± 0.36
Basal Part of Pons4.29 ± 0.9
Cerebellar Cortex3.94 ± 0.6
Cerebellar Nuclei5.22 ± 0.53
Claustrum4.83 ± 0.72
Epithalamus3.87 ± 0.8
Frontal Lobe4.39 ± 0.84
Globus Pallidus6.31 ± 0.52
Hypothalamus3.63 ± 1.06
Insula3.85 ± 0.44
Limbic Lobe4.42 ± 0.9
Mesencephalon4.8 ± 0.82
Myelencephalon4.57 ± 0.79
Occipital Lobe4.53 ± 0.82
Parietal Lobe4.35 ± 0.89
Pontine Tegmentum4.71 ± 0.78
Striatum5.24 ± 0.69
Subthalamus4.94 ± 0.03
Temporal Lobe4.37 ± 0.86
Thalamus4.8 ± 0.55
White Matter5.94 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
KdrCBCerebellum5.69
5.13
KdrCTXCerebral cortex1.78
1.3
KdrHIPHippocampal region4.28
2.97
KdrHPFHippocampal formation4.75
3.37
KdrHYHypothalamus0.88
0.7
KdrLSXLateral septal complex0.97
1.2
KdrMBMidbrain2.09
2.27
KdrMYMedulla5.3
5.07
KdrOLFOlfactory bulb3.41
2.13
KdrPPons3.35
2.48
KdrPALPallidum0.91
0.71
KdrRHPRetrohippocampal region5.35
3.68
KdrsAMYStriatum-like amygdalar nuclei1.03
0.7
KdrSTRStriatum1.02
0.78
KdrSTRdStriatum dorsal region0.89
0.61
KdrSTRvStriatum ventral region1.52
1.22
KdrTHThalamus2.38
2.07
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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