AutismKB 2.0

Annotation Detail for KIF5B


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Basic Information Top
Gene Symbol:KIF5B ( KINH,KNS,KNS1,UKHC )
Gene Full Name: kinesin family member 5B
Band: 10p11.22
Quick LinksEntrez ID:3799; OMIM: 602809; Uniprot ID:KINH_HUMAN; ENSEMBL ID: ENSG00000170759; HGNC ID: 6324
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst3 / 6231948
fetus32 / 56401256
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult236 / 1939121121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma5 / 17475286
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma11 / 82823132
colorectal tumor37 / 114246323
esophageal tumor1 / 1729057
gastrointestinal tumor13 / 119369108
germ cell tumor15 / 26384556
glioma10 / 10688393
head and neck tumor16 / 136302117
kidney tumor7 / 68959101
leukemia3 / 9584231
liver tumor13 / 96359134
lung tumor5 / 10312748
lymphoma3 / 7175541
non-neoplasia12 / 97250123
normal289 / 336030786
ovarian tumor10 / 76682130
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer10 / 10268097
retinoblastoma5 / 46356107
skin tumor34 / 124949272
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites4 / 4001599
bladder5 / 29757168
blood2 / 12347816
bone9 / 71655125
bone marrow4 / 4880181
brain111 / 1100989100
cervix3 / 4817162
connective tissue18 / 149255120
ear3 / 16212185
embryonic tissue24 / 215722111
esophagus1 / 2020949
eye18 / 21105485
heart8 / 8962689
intestine50 / 234472213
kidney18 / 21177784
larynx4 / 24145165
liver18 / 20774386
lung19 / 33697456
lymph3 / 4427067
lymph node2 / 9161021
mammary gland22 / 153271143
mouth4 / 6705259
muscle11 / 107715102
nerve1 / 1576863
ovary12 / 102051117
pancreas17 / 21481279
parathyroid4 / 20539194
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta35 / 280825124
prostate22 / 189345116
salivary gland3 / 20155148
skin44 / 210574208
spleen1 / 5395218
stomach9 / 9661993
testis32 / 33044296
thymus2 / 8113124
thyroid8 / 47473168
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus34 / 232878145
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201991_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts414.45
Adipocyte373.5
AdrenalCortex301.1
Adrenalgland144
Amygdala796.65
Appendix124.75
AtrioventricularNode161.6
BDCA4+_DentriticCells736.55
Bonemarrow63.3
BronchialEpithelialCells466.2
CD105+_Endothelial410.95
CD14+_Monocytes443.7
CD19+_BCells(neg._sel.)401.9
CD33+_Myeloid936.3
CD34+672.6
CD4+_Tcells454.15
CD56+_NKCells669.05
CD71+_EarlyErythroid175.9
CD8+_Tcells381.75
CardiacMyocytes472.65
Caudatenucleus142.35
Cerebellum118.05
CerebellumPeduncles214.75
CiliaryGanglion168.9
CingulateCortex657.4
Colorectaladenocarcinoma360.75
DorsalRootGanglion174
FetalThyroid237.65
Fetalbrain181.05
Fetalliver241.05
Fetallung137.9
GlobusPallidus270.4
Heart77.4
Hypothalamus318.45
Kidney73.3
Leukemia_chronicMyelogenousK-562142.5
Leukemia_promyelocytic-HL-60149.55
Leukemialymphoblastic(MOLT-4)189.3
Liver122.8
Lung194.4
Lymphnode60.4
Lymphoma_burkitts(Daudi)244
Lymphoma_burkitts(Raji)351.1
MedullaOblongata411.15
OccipitalLobe536.4
OlfactoryBulb629.15
Ovary179.8
Pancreas466.45
PancreaticIslet559.75
ParietalLobe497.05
Pituitary715.8
Placenta136
Pons207.6
PrefrontalCortex1169.9
Prostate1273.05
Salivarygland237.05
SkeletalMuscle103.05
Skin144.75
SmoothMuscle818.15
Spinalcord104
SubthalamicNucleus286.15
SuperiorCervicalGanglion194.55
TemporalLobe211.05
Testis244.7
TestisGermCell1047.8
TestisIntersitial710.05
TestisLeydigCell525.7
TestisSeminiferousTubule715.05
Thalamus240.1
Thymus138.3
Thyroid341.05
Tongue234.85
Tonsil317.4
Trachea376
TrigeminalGanglion127.25
Uterus1376.85
UterusCorpus115.85
WholeBlood240.05
Wholebrain325.35
colon726.15
pineal_day882.6
pineal_night744.3
retina576.45
small_intestine288.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15584_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.78 ± 0.38
Basal Forebrain8.31 ± 0.3
Basal Part of Pons7.68 ± 0.23
Cerebellar Cortex7.7 ± 0.16
Cerebellar Nuclei8.3 ± 0.41
Claustrum7.94 ± 0.35
Epithalamus7.92 ± 0.26
Frontal Lobe7.64 ± 0.36
Globus Pallidus8.94 ± 0.19
Hypothalamus7.73 ± 0.37
Insula7.66 ± 0.25
Limbic Lobe7.62 ± 0.3
Mesencephalon7.99 ± 0.43
Myelencephalon7.86 ± 0.37
Occipital Lobe8.11 ± 0.3
Parietal Lobe7.87 ± 0.31
Pontine Tegmentum7.93 ± 0.31
Striatum8.05 ± 0.4
Subthalamus8.06 ± 0.21
Temporal Lobe7.75 ± 0.29
Thalamus7.88 ± 0.31
White Matter9 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kif5bCBCerebellum13.89
10.36
Kif5bCTXCerebral cortex11.1
5.47
Kif5bHIPHippocampal region33.88
18.56
Kif5bHPFHippocampal formation30.2
16.08
Kif5bHYHypothalamus10.42
6.05
Kif5bLSXLateral septal complex10.17
5.45
Kif5bMBMidbrain19.62
13.19
Kif5bMYMedulla34.2
27.77
Kif5bOLFOlfactory bulb16.1
8.48
Kif5bPPons31.57
25.65
Kif5bPALPallidum9.59
6.21
Kif5bRHPRetrohippocampal region22.85
12.01
Kif5bsAMYStriatum-like amygdalar nuclei14.94
7.12
Kif5bSTRStriatum7.06
3.74
Kif5bSTRdStriatum dorsal region5.72
3.32
Kif5bSTRvStriatum ventral region6.07
2.71
Kif5bTHThalamus17.89
9.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KINH_HUMAN_0 0 0 0 GGGAFVQNSQPVAVR PRIDE
KINH_HUMAN_0 0 0 0 ISFLENNLEQLTK PRIDE
KINH_HUMAN_0 0 0 0 QKISFLENNLEQLTKVHK PRIDE
KINH_HUMAN_0 0 0 0 TGAEGAVLDEAK PRIDE
KINH_HUMAN_190 13 190 202 HVAVTNMNEHSSR PRIDE
KINH_HUMAN_2 13 2 14 ADLAECNIKVMCR PRIDE
KINH_HUMAN_256 25 256 280 SLSALGNVISALAEGSTYVPYRDSK PRIDE
KINH_HUMAN_430 18 430 447 QLDDKDEEINQQSQLVEK PRIDE
KINH_HUMAN_465 12 465 476 RDQDNMQAELNR PRIDE
KINH_HUMAN_466 11 466 476 DQDNMQAELNR PRIDE
KINH_HUMAN_476 29 476 504 LQAENDASKEEVKEVLQALEELAVNYDQK PRIDE
KINH_HUMAN_644 12 644 655 SLTEYLQNVEQK PRIDE
KINH_HUMAN_659 17 659 675 QLEESVDALSEELVQLR PRIDE
KINH_HUMAN_699 11 699 709 QAVEQQIQSHR PRIDE
KINH_HUMAN_740 7 740 746 MMLEQER PRIDE
KINH_HUMAN_764 11 764 774 KLHELTVMQDR PRIDE
KINH_HUMAN_780 21 780 800 QDLKGLEETVAKELQTLHNLR PRIDE
KINH_HUMAN_831 13 831 843 ISFLENNLEQLTK PRIDE
KINH_HUMAN_913 28 913 940 RGHSAQIAKPIRPGQHPAASPTHPSAIR PRIDE
KINH_HUMAN_99 12 99 110 LHDPEGMGIIPR PRIDE
PAp00002604 16 172 187 FVCSPDEVMDTIDEGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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