AutismKB 2.0

Annotation Detail for KLRC3


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Basic Information Top
Gene Symbol:KLRC3 ( NKG2-E,NKG2E )
Gene Full Name: killer cell lectin-like receptor subfamily C, member 3
Band: 12p13.2
Quick LinksEntrez ID:3823; OMIM: 602892; Uniprot ID:NKG2E_HUMAN; ENSEMBL ID: ENSG00000205810; HGNC ID: 6376
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal8 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207723_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte7.8
AdrenalCortex10.85
Adrenalgland7.3
Amygdala8.05
Appendix10.2
AtrioventricularNode9
BDCA4+_DentriticCells7.85
Bonemarrow9.2
BronchialEpithelialCells7.75
CD105+_Endothelial7.75
CD14+_Monocytes8.6
CD19+_BCells(neg._sel.)8.05
CD33+_Myeloid9.85
CD34+9.35
CD4+_Tcells8.4
CD56+_NKCells682.6
CD71+_EarlyErythroid7.75
CD8+_Tcells23
CardiacMyocytes15.7
Caudatenucleus7.25
Cerebellum6.6
CerebellumPeduncles10
CiliaryGanglion7.9
CingulateCortex8.5
Colorectaladenocarcinoma7.85
DorsalRootGanglion7.8
FetalThyroid8.1
Fetalbrain7.55
Fetalliver7.25
Fetallung5.9
GlobusPallidus6.7
Heart14.45
Hypothalamus8.3
Kidney7.6
Leukemia_chronicMyelogenousK-5627.15
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)6.25
Liver12.95
Lung8.8
Lymphnode6.4
Lymphoma_burkitts(Daudi)10.75
Lymphoma_burkitts(Raji)12.95
MedullaOblongata7.2
OccipitalLobe7.2
OlfactoryBulb6.35
Ovary6.2
Pancreas6.95
PancreaticIslet8.85
ParietalLobe9.3
Pituitary9.2
Placenta7.55
Pons8.1
PrefrontalCortex9.2
Prostate8.8
Salivarygland6.9
SkeletalMuscle13.4
Skin8.2
SmoothMuscle9.1
Spinalcord8.6
SubthalamicNucleus7.9
SuperiorCervicalGanglion13.15
TemporalLobe7.65
Testis6.75
TestisGermCell6.35
TestisIntersitial6.9
TestisLeydigCell8.45
TestisSeminiferousTubule6.9
Thalamus8.4
Thymus5.8
Thyroid9.15
Tongue9.45
Tonsil8
Trachea6.65
TrigeminalGanglion11.2
Uterus6.2
UterusCorpus8.6
WholeBlood8.8
Wholebrain6.85
colon7.8
pineal_day9.58
pineal_night9.42
retina9.5
small_intestine7.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_789_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.26 ± 0.5
Basal Forebrain4.57 ± 0.31
Basal Part of Pons3.63 ± 0.66
Cerebellar Cortex3.42 ± 0.39
Cerebellar Nuclei4.29 ± 0.39
Claustrum3.33 ± 0.81
Epithalamus3.3 ± 0.9
Frontal Lobe4.01 ± 0.54
Globus Pallidus5.2 ± 0.24
Hypothalamus4.04 ± 0.45
Insula3.97 ± 0.48
Limbic Lobe3.92 ± 0.76
Mesencephalon4.19 ± 0.62
Myelencephalon4.03 ± 0.65
Occipital Lobe3.68 ± 0.53
Parietal Lobe3.79 ± 0.64
Pontine Tegmentum4.18 ± 0.57
Striatum4.8 ± 0.41
Subthalamus3.74 ± 0.18
Temporal Lobe3.99 ± 0.53
Thalamus4.15 ± 0.55
White Matter5.78 ± 0.43
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018