AutismKB 2.0

Annotation Detail for KLC1


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Basic Information Top
Gene Symbol:KLC1 ( KLC,KNS2,KNS2A,MGC15245 )
Gene Full Name: kinesin light chain 1
Band: 14q32.33
Quick LinksEntrez ID:3831; OMIM: 600025; Uniprot ID:KLC1_HUMAN; ENSEMBL ID: ENSG00000126214; HGNC ID: 6387
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst9 / 62319144
fetus187 / 564012331
neonate1 / 3109732
infant3 / 23620127
juvenile16 / 55556287
adult218 / 1939121112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor16 / 94178169
cervical tumor3 / 3436687
chondrosarcoma7 / 8282384
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor15 / 119369125
germ cell tumor49 / 263845185
glioma19 / 106883177
head and neck tumor19 / 136302139
kidney tumor7 / 68959101
leukemia5 / 9584252
liver tumor7 / 9635972
lung tumor12 / 103127116
lymphoma2 / 7175527
non-neoplasia13 / 97250133
normal644 / 3360307191
ovarian tumor7 / 7668291
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer8 / 10268077
retinoblastoma11 / 46356237
skin tumor12 / 12494996
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites9 / 40015224
bladder0 / 297570 
blood11 / 12347889
bone7 / 7165597
bone marrow2 / 4880140
brain485 / 1100989440
cervix3 / 4817162
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue31 / 215722143
esophagus1 / 2020949
eye38 / 211054180
heart7 / 8962678
intestine21 / 23447289
kidney13 / 21177761
larynx3 / 24145124
liver13 / 20774362
lung39 / 336974115
lymph1 / 4427022
lymph node8 / 9161087
mammary gland16 / 153271104
mouth6 / 6705289
muscle6 / 10771555
nerve10 / 15768634
ovary14 / 102051137
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland6 / 16585361
placenta17 / 28082560
prostate17 / 18934589
salivary gland0 / 201550 
skin19 / 21057490
spleen3 / 5395255
stomach6 / 9661962
testis19 / 33044257
thymus4 / 8113149
thyroid9 / 47473189
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus32 / 232878137
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212877_at
Cell line Expression level Expression bar
721_B_lymphoblasts34.55
Adipocyte7.15
AdrenalCortex8.35
Adrenalgland6.6
Amygdala1784.3
Appendix7.7
AtrioventricularNode5.85
BDCA4+_DentriticCells18.5
Bonemarrow7.65
BronchialEpithelialCells8.55
CD105+_Endothelial7.3
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)7.85
CD33+_Myeloid9.7
CD34+11.9
CD4+_Tcells7.05
CD56+_NKCells9.7
CD71+_EarlyErythroid8.3
CD8+_Tcells6.3
CardiacMyocytes11.25
Caudatenucleus190
Cerebellum491.6
CerebellumPeduncles729.3
CiliaryGanglion26.15
CingulateCortex445.8
Colorectaladenocarcinoma13.1
DorsalRootGanglion120.25
FetalThyroid7.85
Fetalbrain899.6
Fetalliver6
Fetallung5.4
GlobusPallidus347.25
Heart11.35
Hypothalamus849.9
Kidney6
Leukemia_chronicMyelogenousK-5626.6
Leukemia_promyelocytic-HL-6010.15
Leukemialymphoblastic(MOLT-4)6.3
Liver10.15
Lung8.65
Lymphnode5.55
Lymphoma_burkitts(Daudi)17.85
Lymphoma_burkitts(Raji)20.1
MedullaOblongata469.65
OccipitalLobe756.7
OlfactoryBulb6.75
Ovary4.9
Pancreas5.75
PancreaticIslet8.4
ParietalLobe456.5
Pituitary18.75
Placenta7.3
Pons238.45
PrefrontalCortex776.05
Prostate9.25
Salivarygland6.15
SkeletalMuscle9.3
Skin5.9
SmoothMuscle18.4
Spinalcord251.7
SubthalamicNucleus511.05
SuperiorCervicalGanglion8.9
TemporalLobe492.9
Testis6.85
TestisGermCell6.65
TestisIntersitial6.8
TestisLeydigCell8.7
TestisSeminiferousTubule7
Thalamus611.75
Thymus6.25
Thyroid9.5
Tongue7.6
Tonsil7.5
Trachea6.1
TrigeminalGanglion8.4
Uterus6.1
UterusCorpus7.1
WholeBlood7.65
Wholebrain1207.2
colon7.35
pineal_day423.36
pineal_night592.74
retina90.4
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P922877
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.63 ± 0.16
Basal Forebrain9.19 ± 0.18
Basal Part of Pons8.55 ± 0.33
Cerebellar Cortex8.51 ± 0.12
Cerebellar Nuclei9.26 ± 0.37
Claustrum8.33 ± 0.45
Epithalamus9.21 ± 0.44
Frontal Lobe8.74 ± 0.45
Globus Pallidus10.03 ± 0.22
Hypothalamus8.7 ± 0.4
Insula8.72 ± 0.23
Limbic Lobe8.56 ± 0.48
Mesencephalon8.93 ± 0.53
Myelencephalon8.91 ± 0.44
Occipital Lobe8.94 ± 0.42
Parietal Lobe8.67 ± 0.38
Pontine Tegmentum8.94 ± 0.38
Striatum9.42 ± 0.33
Subthalamus9.06 ± 0.35
Temporal Lobe8.73 ± 0.33
Thalamus9.11 ± 0.36
White Matter10.35 ± 0.41
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KLC1_HUMAN_143 9 143 151 HLEFMNQLK PRIDE
KLC1_HUMAN_241 21 241 261 TSGHDHPDVATMLNILALVYR PRIDE
KLC1_HUMAN_473 16 473 488 QGKFEAAETLEEAAMR PRIDE
PAp00001159 14 55 68 CLKKDDESNLVEEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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