AutismKB 2.0

Annotation Detail for KIF11


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Basic Information Top
Gene Symbol:KIF11 ( EG5,HKSP,KNSL1,TRIP5 )
Gene Full Name: kinesin family member 11
Band: 10q23.33
Quick LinksEntrez ID:3832; OMIM: 148760; Uniprot ID:KIF11_HUMAN; ENSEMBL ID: ENSG00000138160; HGNC ID: 6388
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus14 / 56401224
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor5 / 34366145
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor16 / 26384560
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal64 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow2 / 4880140
brain6 / 11009895
cervix5 / 48171103
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus1 / 2020949
eye1 / 2110544
heart1 / 8962611
intestine11 / 23447246
kidney2 / 2117779
larynx0 / 241450 
liver5 / 20774324
lung7 / 33697420
lymph0 / 442700 
lymph node14 / 91610152
mammary gland5 / 15327132
mouth4 / 6705259
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach6 / 9661962
testis17 / 33044251
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus8 / 23287834
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204444_at
Cell line Expression level Expression bar
721_B_lymphoblasts274.8
Adipocyte5.85
AdrenalCortex6.95
Adrenalgland5.3
Amygdala5.95
Appendix7.15
AtrioventricularNode5.35
BDCA4+_DentriticCells6.7
Bonemarrow7
BronchialEpithelialCells5.85
CD105+_Endothelial167.95
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)6.15
CD33+_Myeloid8
CD34+64.75
CD4+_Tcells6.1
CD56+_NKCells8.25
CD71+_EarlyErythroid185.3
CD8+_Tcells5.35
CardiacMyocytes20
Caudatenucleus5.35
Cerebellum4.9
CerebellumPeduncles7.05
CiliaryGanglion5.1
CingulateCortex6.4
Colorectaladenocarcinoma51.8
DorsalRootGanglion5.05
FetalThyroid5.85
Fetalbrain5.75
Fetalliver19.1
Fetallung4.65
GlobusPallidus4.7
Heart8.9
Hypothalamus6.25
Kidney5.3
Leukemia_chronicMyelogenousK-56219.95
Leukemia_promyelocytic-HL-6064.5
Leukemialymphoblastic(MOLT-4)184.1
Liver9.2
Lung6.5
Lymphnode4.9
Lymphoma_burkitts(Daudi)81.45
Lymphoma_burkitts(Raji)8.95
MedullaOblongata5.35
OccipitalLobe5.3
OlfactoryBulb4.65
Ovary4.35
Pancreas5
PancreaticIslet6.45
ParietalLobe6.6
Pituitary6.9
Placenta5.9
Pons5.9
PrefrontalCortex7.15
Prostate6.8
Salivarygland4.95
SkeletalMuscle8.85
Skin5.6
SmoothMuscle6.7
Spinalcord6.35
SubthalamicNucleus5.65
SuperiorCervicalGanglion9.15
TemporalLobe5.6
Testis5.15
TestisGermCell5.65
TestisIntersitial5.25
TestisLeydigCell6.1
TestisSeminiferousTubule5.1
Thalamus6.2
Thymus5.35
Thyroid7.2
Tongue6.25
Tonsil10.05
Trachea4.95
TrigeminalGanglion7.15
Uterus4.7
UterusCorpus7.15
WholeBlood6.45
Wholebrain4.75
colon6.55
pineal_day7.26
pineal_night7.16
retina7.2
small_intestine5.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P52278
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.55 ± 1.2
Basal Forebrain2.08 ± 0.4
Basal Part of Pons2.05 ± 0.95
Cerebellar Cortex1.99 ± 0.95
Cerebellar Nuclei2.41 ± 0.74
Claustrum2.98 ± 0.86
Epithalamus2 ± 1.04
Frontal Lobe2.12 ± 0.91
Globus Pallidus2.76 ± 0.6
Hypothalamus2.32 ± 0.66
Insula1.77 ± 0.78
Limbic Lobe2.09 ± 0.85
Mesencephalon2.38 ± 0.94
Myelencephalon2.21 ± 0.82
Occipital Lobe2.19 ± 1.07
Parietal Lobe2.22 ± 1.02
Pontine Tegmentum2.3 ± 0.94
Striatum2.42 ± 0.86
Subthalamus2.47 ± 1.17
Temporal Lobe2.15 ± 0.95
Thalamus2.15 ± 0.87
White Matter2.37 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kif11CBCerebellum0.55
1
Kif11CTXCerebral cortex0.5
0.76
Kif11HIPHippocampal region0.48
0.65
Kif11HPFHippocampal formation0.46
0.58
Kif11HYHypothalamus0.12
0.25
Kif11LSXLateral septal complex1.53
2.41
Kif11MBMidbrain0.14
0.15
Kif11MYMedulla0.21
0.37
Kif11OLFOlfactory bulb0.95
2.11
Kif11PPons0.22
0.32
Kif11PALPallidum0.28
0.52
Kif11RHPRetrohippocampal region0.38
0.45
Kif11sAMYStriatum-like amygdalar nuclei0.49
0.5
Kif11STRStriatum0.82
1.17
Kif11STRdStriatum dorsal region0.77
1.19
Kif11STRvStriatum ventral region0.19
0.21
Kif11THThalamus0.21
0.36
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KIF11_HUMAN_920 11 920 930 LDIPTGTTPQR PRIDE
KIF11_HUMAN_932 10 932 941 SYLYPSTLVR PRIDE
PAp00064239 15 522 536 AVDQHNAEAQDIFGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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